Bp367 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Bp367 (Blood pressure QTL 367) Rattus norvegicus

Symbol: Bp367
Name: Blood pressure QTL 367
RGD ID: 7488931
Previously known as: C2QTL1
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: mean arterial blood pressure   (CMO:0000009)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,401,804 - 142,323,610RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02144,631,170 - 148,295,508RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02164,047,103 - 167,706,680RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42144,445,607 - 147,424,436RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.MNS-(D2Rat183-D2Chm113)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Pfn2 is a candidate Gene for Bp367

Disease Annotations     Click to see Annotation Detail View
Hypotension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
2. Cardiac pathways distinguish two epistatic modules enacting BP quantitative trait loci and candidate gene analysis. Chauvet C, etal., Hypertens Res. 2009 Jul;32(7):631-7. doi: 10.1038/hr.2009.70. Epub 2009 May 22.
Related QTLs

Related QTL Description Reference
Bp256 sub_region RGD:7421631


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
68437Dclk1doublecortin-like kinase 12139417234139710956Rat
7581938LOC102552324uncharacterized LOC1025523242139569183139577314Rat
1562629Nbeaneurobeachin2139780021140338639Rat
7726710LOC102552834uncharacterized LOC1025528342139906425139915076Rat
1589984Mab21l1mab-21 like 12139943496139945885Rat
7664166LOC102552778uncharacterized LOC1025527782139990888139994618Rat
41237368LOC120101340small nucleolar RNA SNORA172140311336140311463Rat
41022771LOC120101343small nucleolar RNA SNORA172140617246140617361Rat
1560498Eif3i-ps1eukaryotic translation initiation factor 3, subunit I, pseudogene 12140669273140670304Rat
7507353Nsa2-ps23NSA2 ribosome biogenesis factor, pseudogene 232140781011140781859Rat
41145339LOC120100824uncharacterized LOC1201008242140835560140873684Rat
1309652Tm4sf1transmembrane 4 L six family member 12141456950141466146Rat
1563943Mcm4-ps1minichromosome maintenance complex component 4, pseudogene 12141550579141554296Rat
41329676LOC120101218U7 small nuclear RNA2141562874141562937Rat
621784Tm4sf4transmembrane 4 L six family member 42141570321141621263Rat
1559609Wwtr1WW domain containing transcription regulator 12141651159141766919Rat
6503572Rpl12-ps2ribosomal protein L12, pseudogene 22141784371141785085Rat
1588810Commd2COMM domain containing 22141848661141852907Rat
11368573LOC108350015uncharacterized LOC1083500152141852931141862943Rat
2320491Ankub1ankyrin repeat and ubiquitin domain containing 12141857623141894624Rat
1566235Rpl36al-ps1ribosomal protein L36A, pseudogene 12141892707141893102Rat
1594062Rnf13ring finger protein 132141927887142061801Rat
40964933Trnap-agg40transfer RNA proline (anticodon AGG) 402142013652142013733Rat
9269847LOC10369511960S ribosomal protein L34 pseudogene2142026133142030412Rat
621826Pfn2profilin 22142067102142072938Rat
40936546LOC120100826uncharacterized LOC1201008262142100003142122325Rat
6500885Nono-ps2non-POU domain containing, octamer-binding, pseudogene 22142109424142112044Rat
41156453LOC120100828uncharacterized LOC1201008282142177984142189551Rat
6501036Kmt5al1lysine methyltransferase 5A like 12142289672142292195Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33983D2Mit232642141596551141596857Ratregion
34114D2Mgh151502141194931141195087Ratregion
37768D2Rat1661462140636016140636154Ratregion
39616D2Rat2562262140397825140398049Ratregion
42289D2Rat3731202140171409140171528Ratregion
41300D2Rat2211672140689412140689571Ratregion
40780D2Rat2222382140253741140253961Ratregion
66480D2Uia151322140734737140734869Ratregion
1358000D2Chm1132482140708701140708949Ratregion
1358019D2Chm1221972139401804139402001Ratregion
1358052D2Chm902422142323368142323610Ratregion
1640946D2Got3311482140790294140790442Ratregion
5031618AU0477181792140646980140647159Ratregion
5028963RH1429911162140779374140779490Ratregion
5032523T034091952139780052139780247Ratregion
5025474RH1284601842142243899142244083Ratregion
5033619RH1394882052139710646139710851Ratregion
5031009BF4058762282141927018141927246Ratregion
5031015AA9631942192139638475139638694Ratregion
5055195RH1436611612139589861139590022Ratregion
5058902BF3872081682139656970139657138Ratregion
5059848BF3946092112140311006140311217Ratregion
5050326RH1339911902139465375139465565Ratregion
5050002RH1338051962141457273141457469Ratregion
5054531RH1432781122141850336141850448Ratregion
5051102RH1344411882141554236141554419Ratregion
5046290RH13166702141549810141550037Ratregion
5046820RH1319732052141445722141445927Ratregion
5040394RH1282581822141457699141457881Ratregion
5080174RH1414282142139638085139638299Ratregion
5078400RH1403201752139710677139710852Ratregion
5070790RH1347071972141850106141850303Ratregion
5074368RH1379771852139695387139695572Ratregion
5074886RH1382751522139672956139673108Ratregion
5067180AU0479121882141672999141673187Ratregion
5067408AU0477671272139514242139514369Ratregion
5070346AI8367581422139710570139710712Ratregion
5070440AW047968802139945497139945577Ratregion
5062232BE1063901622139700456139700618Ratregion
5060704BE1043141602140015744140015904Ratregion
5062758AW5343032082139432187139432395Ratregion
5063592BE1078021532140051014140051167Ratregion
5064476BE1080491502141567880141568030Ratregion
5064862BF4052111862139786028139786214Ratregion
5089815AU0493792032141616199141616402Ratregion
5088293AU0484832062140800500140800706Ratregion
5082023BF4156731592140310302140310461Ratregion
5499785UniSTS:2346882702141649159141649429Ratregion
5500517RH1358401022141851396141851987Ratregion
Position Markers

Flank 1: (D2Chm122)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22139,401,804 - 139,402,001 (+)MAPPER
Rnor_6.02144,631,170 - 144,631,366NCBI
Rnor_5.02164,047,103 - 164,047,299UniSTS
RGSC_v3.42144,445,607 - 144,445,803UniSTS
Celera2133,886,345 - 133,886,555UniSTS
Cytogenetic Map2 RGD
Flank 2: (D2Chm90)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22142,323,368 - 142,323,610 (+)MAPPER
Rnor_6.02148,295,267 - 148,295,508NCBI
Rnor_5.02167,706,439 - 167,706,680UniSTS
RGSC_v3.42147,424,195 - 147,424,436UniSTS
Celera2136,755,765 - 136,756,448UniSTS
Celera2136,755,765 - 136,755,986UniSTS
Cytogenetic Map2 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
12879830Bw178Body weight QTL 1780.001body mass (VT:0001259)body weight (CMO:0000012)2137219876142323610Rat
12879831Cm82Cardiac mass QTL 820.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2137219876142323610Rat
12879832Cm83Cardiac mass QTL 830.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2137219876142323610Rat
12879833Cm84Cardiac mass QTL 840.001heart right ventricle mass (VT:0007033)heart weight to body weight ratio (CMO:0000074)2137219876142323610Rat
12879834Am1Aortic mass QTL 10.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2137219876142323610Rat
12879835Kidm60Kidney mass QTL 600.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2137219876142323610Rat
1549841Bp256Blood pressure QTL 2560.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2137219876142323610Rat
7488931Bp367Blood pressure QTL 3670.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2139401804142323610Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2142323368146786035Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2142323368146786035Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2142323368146786035Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2142323368146786035Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368147803808Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general measurement method: selected males were weaned at 21 days of age then fed 2% NaCl diet starting from 35 days of age; telemetric probes were implanted at 56 days of age 7421631
qtl_general number of animals used: 12 gender: male 7421631
qtl_general software package used: ANOVA followed by Dunnett test 7421631
qtl_general region spans 2.98 Mb and 10 genes reside in this region 7421631