Niddm53 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Niddm53 (Non-insulin dependent diabetes mellitus QTL 53) Rattus norvegicus

Symbol: Niddm53
Name: Non-insulin dependent diabetes mellitus QTL 53
RGD ID: 724541
Previously known as: Nidd16/of
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level area under curve (AUC)   (CMO:0000350)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2143,813,074 - 9,088,978RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0144,833,233 - 10,729,268RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0144,830,815 - 10,676,655RGDRnor5.0
RGSC_v3.4144,895,894 - 10,340,377RGDRGSC3.4
RGSC_v3.1144,895,895 - 10,340,272RGD
Cross Type: intercross
Strains Crossed: F344/DuCrlCrlj OLETF/Got 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat. Yamada T, etal., Exp Anim 2001 Apr;50(2):115-23.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1592829Zfp326zinc finger protein 3261439412103980419Rat
41153909LOC120096556uncharacterized LOC1200965561440160024024309Rat
1309601Lrrc8dleucine rich repeat containing 8 VRAC subunit D1440299714134922Rat
1306585Lrrc8cleucine rich repeat containing 8 VRAC subunit C1442239014315590Rat
41089131LOC120096783small nucleolar RNA SNORA36 family1443119194312050Rat
11466948LOC108352696uncharacterized LOC1083526961443239154325615Rat
1563429Lrrc8bleucine rich repeat containing 8 VRAC subunit B1443504624416336Rat
11381376LOC108352839uncharacterized LOC1083528391444397084444361Rat
7646169Gbp6-ps3guanylate binding protein 6, pseudogene 31444740874708888Rat
1359703Abcg3l2ATP-binding cassette, subfamily G (WHITE), member 3-like 21444932594538264Rat
1588538Abcg3l4ATP-binding cassette, subfamily G (WHITE), member 3-like 41445452064590223Rat
41202894LOC120096559uncharacterized LOC1200965591445855044587305Rat
41393193LOC120096739U6 spliceosomal RNA1446326424632748Rat
2325094Gbp6-ps1guanylate binding protein 6, pseudogene 11446617844678989Rat
1587144Ube2v1l1ubiquitin conjugating enzyme E2 V1 like 11447032434704962Rat
1561523Gbp6guanylate binding protein family member 61447302864756508Rat
1565568Abcg3ATP-binding cassette, subfamily G (WHITE), member 31447635524839061Rat
41307086LOC120096745U6 spliceosomal RNA1447980324798138Rat
41193840LOC120096854small nucleolar RNA U31448159744816072Rat
41113676LOC120096558uncharacterized LOC1200965581448326074841231Rat
1564709Abcg3l3ATP-binding cassette, subfamily G (WHITE), member 3-like 31448441614892194Rat
2324613Zfp658l1zinc finger protein 658-like 11448894864938248Rat
11430399Zfp950l12zinc finger protein 950 like 121449640044980011Rat
7686608Zfp866l1zinc finger protein 866 like 11450036585026217Rat
2301011Zfp951zinc finger protein 9511450324945048775Rat
7616489Zfp996l1zinc finger protein 996 like 11450573195072903Rat
40960387Zfp996l2zinc finger protein 996 like 21450812435082649Rat
7621998Zfp951l1zinc finger protein 951 like 11451052685108118Rat
1303294Abcg3l1ATP-binding cassette, subfamily G (WHITE), member 3-like 11451245415177265Rat
1583596Thoc2lTHO complex subunit 2-like1451970935234960Rat
1559992Pkd2polycystin 2, transient receptor potential cation channel1452371355280455Rat
3752Spp1secreted phosphoprotein 11453088855315120Rat
6499958LOC100910198uncharacterized LOC1009101981454193475435372Rat
71036Mepematrix extracellular phosphoglycoprotein1454206345432186Rat
2855Ibspintegrin-binding sialoprotein1454398255452570Rat
41366938LOC120096547uncharacterized LOC1200965471455139575516173Rat
2508Dmp1dentin matrix acidic phosphoprotein 11455284415542078Rat
11423237LOC108352697uncharacterized LOC1083526971455469735569298Rat
2525Dsppdentin sialophosphoprotein1455655625571669Rat
2531Sparcl1SPARC like 11456328165663866Rat
2323137Scpppq1secretory calcium-binding phosphoprotein proline-glutamine rich 11456640055675252Rat
1359522Nudt9nudix hydrolase 91456753765693332Rat
1303235Hsd17b11hydroxysteroid (17-beta) dehydrogenase 111456933045743157Rat
1359553Hsd17b13hydroxysteroid (17-beta) dehydrogenase 131457516975766809Rat
1304685Klhl8kelch-like family member 81458077955853325Rat
41148703LOC120096561uncharacterized LOC1200965611458266225828757Rat
1307940Aff1ALF transcription elongation factor 11458611886024196Rat
1564576C14h4orf36similar to human chromosome 4 open reading frame 361460585816065848Rat
7702897LOC102546534uncharacterized LOC1025465341460747946077095Rat
727800Slc10a6solute carrier family 10 member 61460807166102902Rat
1563360Ptpn13protein tyrosine phosphatase, non-receptor type 131461082026282619Rat
1560413Ndufb4l1NADH:ubiquinone oxidoreductase subunit B4-like 11463658726366282Rat
11392357LOC108352699uncharacterized LOC1083526991463861326424780Rat
3663Mapk10mitogen activated protein kinase 101464976626790109Rat
41070389LOC120096564uncharacterized LOC1200965641465131636530122Rat
41199361LOC120096563cytochrome c oxidase assembly protein COX20, mitochondrial-like1465677336568059Rat
41240491LOC120096701peptidyl-prolyl cis-trans isomerase FKBP2-like1466792296679870Rat
1306669Arhgap24Rho GTPase activating protein 241468006247183877Rat
7632243LOC102549277uncharacterized LOC1025492771472581687268578Rat
11416353LOC108352704uncharacterized LOC1083527041473351757347219Rat
41284210LOC120096727uncharacterized LOC1200967271474014657408299Rat
1560931Pcna-ps3proliferating cell nuclear antigen, pseudogene 31474652537482926Rat
1597134Tbc1d1-ps1TBC1 domain family member 1, pseudogene 11475237507530777Rat
1307097Wdfy3WD repeat and FYVE domain containing 31475782457810491Rat
621185Cds1CDP-diacylglycerol synthase 11478203287882943Rat
11389755LOC108352705uncharacterized LOC1083527051478830857884663Rat
11482723LOC108352706uncharacterized LOC1083527061479388597947343Rat
69318Nkx6-1NK6 homeobox 11479697567976689Rat
1597133Rpl36-ps1ribosomal protein L36, pseudogene1482570288257342Rat
41025388LOC120096865U6 spliceosomal RNA1483304688330574Rat
7589278LOC102550272uncharacterized LOC1025502721484437708469404Rat
1585864Set-ps15Set nuclear proto-oncogene, pseudogene 151485173018519537Rat
11441489LOC108352708uncharacterized LOC1083527081486494348676819Rat
1565703Gpat3glycerol-3-phosphate acyltransferase 31487153678768051Rat
1305287Abraxas1abraxas 1, BRCA1 A complex subunit1487962818810625Rat
1307997Mrps18cmitochondrial ribosomal protein S18C1488123018818538Rat
1560216Helqhelicase, POLQ-like1488185828862926Rat
11467926LOC108352710uncharacterized LOC1083527101488804948888096Rat
61969Hpseheparanase1488965938937011Rat
41392218Ppid-ps10peptidylprolyl isomerase D, pseudogene 101489161688918133Rat
1306722Coq2coenzyme Q2, polyprenyltransferase1489414298961418Rat
41017864LOC120096567uncharacterized LOC1200965671489761308980582Rat
2322973LOC100363472nuclear receptor-binding factor 2-like1489843658986171Rat
1308102Plac8placenta associated 81490526019074264Rat
1302952Cops4COP9 signalosome subunit 41490785799108788Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33937D14Mit111431438570383857178Ratregion
36053D14Rat41341481706688170790Ratregion
37030D14Rat31591490888099088978Ratregion
36536D14Rat11441438130743813216Ratregion
39860D14Rat731941485443128544522Ratregion
39204D14Rat542201440418724042062Ratregion
41984D14Arb12721454404385440710Ratregion
41438D14Rat721731464761076476292Ratregion
42386D14Rat1422461457482455748477Ratregion
45143D14Got72441441463534146597Ratregion
45144D14Got81561444566974456852Ratregion
45146D14Got101721458895485889720Ratregion
60083D14Got92211459921065992327Ratregion
45306D14Got171451475365267536671Ratregion
60056D14Got111171459356435935760Ratregion
60057D14Got141711484858848486055Ratregion
1629285D14Got1572441439331113933350Ratregion
1635099D14Got1471001475915087591606Ratregion
1634005D14Wox221631456635145663677Ratregion
5036053UniSTS:463464611490695529069613Ratregion
5038934RH1274171941461085306108724Ratregion
5035625D21S1917471456473455647929Ratregion
5035709SPARCL1961456582285658324Ratregion
7206154UniSTS:5322818211467848186785639Ratregion
5026266RH1315541801488126068812870Ratregion
5028855RH1425862121452118805212092Ratregion
5028887RH1427031441463514546351598Ratregion
5034205RH1417642201489356368935856Ratregion
5034221RH1418241801489295338929714Ratregion
5026780RH1335011811487144688714649Ratregion
5029533AA8596161981478102077810405Ratregion
5035352AW5299131941456509205651114Ratregion
5032705RH1349931931448443744844567Ratregion
5035304AI1032852021461237056123907Ratregion
5025004AA6901791241489354488935572Ratregion
5030323BF4023272471473352347335481Ratregion
5027771RH946781651453090085309173Ratregion
5030801BE1202001741465388066538980Ratregion
5028448AI3261151771442280294228206Ratregion
5031073BE1157921721476875947687766Ratregion
5054923RH1435021611457362065736367Ratregion
5054947RH1435171911452344185234609Ratregion
5051823RH946791891454401365440324Ratregion
5051827RH946812491455305995530848Ratregion
5057424BF4183281291487765108776639Ratregion
5057432BF4184321381443526504352788Ratregion
5059510BE0971391951454304815430676Ratregion
5057884BF392886961467892276789323Ratregion
5058838BF393702911467107416710832Ratregion
505217310.MHAa98e10.seq1671462815576281724Ratregion
5059104BE1028251651458095795809744Ratregion
5054265RH1431251541446329604633115Ratregion
5054265RH1431251541447976674797821Ratregion
5040798RH1284891921457427735742965Ratregion
5043326RH1299621631478015617801723Ratregion
5045468RH1311951871457429435743130Ratregion
5041490RH1288861901489367368936926Ratregion
5044992RH1309211991458613705861569Ratregion
5049180RH1333312041456635205663724Ratregion
5046692RH1319001851467854706785655Ratregion
5049670RH1336141801451972695197451Ratregion
5042536RH1294942181453090165309234Ratregion
5042118RH1292501921448919324892124Ratregion
5041012RH1286122201474650107465236Ratregion
5072636RH1369642101453088905309100Ratregion
5073996RH1377591991467689206769119Ratregion
5075674RH1387311931439414843941677Ratregion
5072404RH1368291221468559786856100Ratregion
5074532RH1380712091439473923947595Ratregion
5074716RH1381771231461027156102838Ratregion
5077010RH1395072191467783286778547Ratregion
5077148RH1395892171443532854353503Ratregion
5076322RH1391081281458530275853155Ratregion
5079648RH1411232121452157395217149Ratregion
5077328RH1396932141468559786856192Ratregion
5076370RH1391362351448665374866773Ratregion
5077406RH1397382191457664745766693Ratregion
5078428RH1403372371467783186778555Ratregion
5078608RH1404422491443532534353503Ratregion
5072974RH1371611861489440518944237Ratregion
5080446RH1415831801452372775237457Ratregion
5070556RH1345691931468008936801086Ratregion
5073984RH1377521781456435065643685Ratregion
5074166RH1378602441458522815852525Ratregion
5071836RH1353132201442660654266285Ratregion
5073646RH1375561241442557094255833Ratregion
5063348BE1075791761454206795420855Ratregion
5067074AU0479812981478319307832228Ratregion
5067090AU0479701431460699166070059Ratregion
5068972AU0468081411485918348591970Ratregion
5065394BE1153231501489250008925150Ratregion
5060846BF3892011241440139614014085Ratregion
5062770AW5343921531444397634439916Ratregion
5061960BI2944861731452389135239086Ratregion
5060542BE1103021651452924655292630Ratregion
5062528BI2889221581441284024128560Ratregion
5061040BF4017021571443981894398346Ratregion
5086494BQ2063301991441228634123062Ratregion
5089455AU0491661801440738524074034Ratregion
5083769AI1054321361456895665689702Ratregion
5083861AI2308201801490714119071590Ratregion
5088399AU0485461851459918775992236Ratregion
5088399AU0485461851459920515992236Ratregion
5081210RH1420282181452538315254049Ratregion
5085463BE0969012011457325285732727Ratregion
5085491BE0969671651442682644268429Ratregion
5082651BE1199301581459272185927376Ratregion
5086094BF3877111611439465613946722Ratregion
5507719G392001751464335036433678Ratregion
5504636PMC316977P23451453094245309769Ratregion
5505322Aff115971459300275931624Ratregion
5506171AFM350VD14381477014687702102Ratregion
5506602UniSTS:2804071841453106245312028Ratregion
5500895D21S127011601489112698912431Ratregion
Position Markers

Flank 1: (D14Rat1)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2143,813,074 - 3,813,216 (+)MAPPER
Rnor_6.0144,833,233 - 4,833,374NCBI
Rnor_5.0144,830,815 - 4,830,956UniSTS
RGSC_v3.4144,895,894 - 4,896,036RGD
RGSC_v3.4144,895,895 - 4,896,036UniSTS
RGSC_v3.1144,895,895 - 4,896,036RGD
Celera143,806,493 - 3,806,634UniSTS
RH 3.4 Map1475.7UniSTS
RH 3.4 Map1475.7RGD
RH 2.0 Map1490.7RGD
SHRSP x BN Map142.29RGD
FHH x ACI Map141.33RGD
Flank 2: (D14Rat3)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2149,088,809 - 9,088,978 (+)MAPPER
mRatBN7.21242,824,821 - 242,824,860 (+)MAPPER
mRatBN7.21242,824,825 - 242,824,866 (+)MAPPER
Rnor_6.01410,729,098 - 10,729,268NCBI
Rnor_5.01410,676,485 - 10,676,655UniSTS
RGSC_v3.41410,339,971 - 10,340,377RGD
RGSC_v3.41410,340,102 - 10,340,272UniSTS
RGSC_v3.11410,340,102 - 10,340,272RGD
Celera149,197,754 - 9,197,924UniSTS
RH 3.4 Map14152.08UniSTS
RH 3.4 Map14152.08RGD
RH 2.0 Map14162.0RGD
SHRSP x BN Map144.62RGD
Cytogenetic Map14p22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Niddm53

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general markers are only 2 cM apart; involved in epistatic interactions with Niddm 52; Niddm55 and Niddm56 619670