Uae8 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Uae8 (Urinary albumin excretion QTL 8) Rattus norvegicus

Symbol: Uae8
Name: Urinary albumin excretion QTL 8
RGD ID: 724540
Trait: urine albumin amount   (VT:0002871)    
Measurement Type: urine albumin level   (CMO:0000130)    
LOD Score: 5.0
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2828,157,323 - 30,848,259RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0830,845,450 - 33,558,764RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0833,603,024 - 100,888,674RGDRnor5.0
RGSC_v3.4832,203,394 - 98,986,263RGDRGSC3.4
RGSC_v3.1832,212,161 - 99,005,718RGD
Cross Type: intercross
Strains Crossed: SS/JrTol SHR/NHsd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
Albuminuria  (IDA)
proteinuria  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
SHR/NHsd  (IEA)
SS/JrTol  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. Garrett MR, etal., J Am Soc Nephrol 2003 May;14(5):1175-87.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
620958Ntmneurotrimin82737658228366604Rat
41248071LOC120094317uncharacterized LOC12009431782817478528180928Rat
11468735LOC108351666uncharacterized LOC10835166682869955728719497Rat
1593196Eef1g-ps12eukaryotic translation elongation factor 1 gamma, pseudogene 1282875777028759100Rat
11508065Rpl30-ps5ribosomal protein L30, pseudogene 582882418728825623Rat
1309857Snx19sorting nexin 1982882988128867600Rat
1309770Adamts15ADAM metallopeptidase with thrombospondin type 1 motif, 1582930786429331249Rat
41030317LOC120094102uncharacterized LOC12009410282933898529351451Rat
1308511Adamts8ADAM metallopeptidase with thrombospondin type 1 motif, 882934907829368413Rat
41237972LOC120094540U4 spliceosomal RNA82938420129384396Rat
1308984Zbtb44zinc finger and BTB domain containing 4482946605529524027Rat
69288St14ST14 transmembrane serine protease matriptase82954080529581704Rat
2128Aplp2amyloid beta precursor like protein 282959923029662311Rat
41324635LOC120094529small nucleolar RNA U1382971468029714776Rat
41126221LOC120094555U6 spliceosomal RNA82971536129715467Rat
11405255Nop16-ps1NOP16 nucleolar protein, pseudogene 182971901429719609Rat
1560384Prdm10PR/SET domain 1082972401129827757Rat
1563958Rpl32l1ribosomal protein L32 like 182973344329733850Rat
1310558Nfrkbnuclear factor related to kappa B binding protein82983180229863360Rat
1305586Tmem45btransmembrane protein 45b82986527629910453Rat
1585923Amd2l-ps1S-adenosylmethionine decarboxylase 2 like, pseudogene 182994292129954379Rat
1597169Prps1-ps1phosphoribosyl pyrophosphate synthetase 1, pseudogene 182999007829991600Rat
1584840Barx2BARX homeobox 283025113230319105Rat
11384229LOC108351669uncharacterized LOC10835166983025785430260758Rat
1597168Rps19l2ribosomal protein S19 like 283035712830357523Rat
1584797Cct6a-ps7chaperonin containing Tcp1, subunit 6A (zeta 1), pseudogene 783036232930366063Rat
1562690Ldhal1lactate dehydrogenase A like 183036322030364836Rat
1305267Arhgap32Rho GTPase activating protein 3283042126930681653Rat
1593195Rpl35l2ribosomal protein L35 like 283063417330634690Rat
61971Kcnj5potassium inwardly-rectifying channel, subfamily J, member 583072492330753083Rat
41376517LOC120094481small nucleolar RNA SNORA4883077360030773730Rat
2957Kcnj1potassium inwardly-rectifying channel, subfamily J, member 183077988330808607Rat
1309837Fli1Fli-1 proto-oncogene, ETS transcription factor83083142230950468Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33559D8Mit512283084815430848259Ratregion
35481D8Rat5016782934137529341542Ratregion
37742D8Rat16317683018886730189043Ratregion
35663D8Rat5115682824291228243068Ratregion
40746D8Rat16224982950266529502918Ratregion
42242D8Arb520082957297629573171Ratregion
44372D8Got3920482975167629751880Ratregion
44373D8Got3220783063618330636392Ratregion
44375D8Got3529982987214629872445Ratregion
60627D8Got4022083066920130669418Ratregion
1628575D8Wox2617383080802230808195Ratregion
1640284D8M9Mit18843182980335729803788Ratregion
7205968St148282954416329544868Ratregion
5038834RH12735918282986285629863038Ratregion
5039016RH12746418882959941129599599Ratregion
5036809AU04927411082972922329729333Ratregion
5029339RH14442015182886732628867477Ratregion
5029851AW53053120882954893029549138Ratregion
5034984Fli114683083291130833057Ratregion
5027379X5942110083083282830832928Ratregion
5035184BE09694915882886291528863073Ratregion
5053787RH14285010682859594028596046Ratregion
5059398AW53058019683072561030725806Ratregion
5041654RH12898119182951783429518025Ratregion
5049066RH13326620683072502230725228Ratregion
5048162RH13274421783031912930319346Ratregion
5048354RH13285518483025988330260721Ratregion
5074994RH13833819982957133429571533Ratregion
5077422RH13974720583083149730831702Ratregion
5080370RH14154019482954089329541087Ratregion
5071556RH13515018482930804029308224Ratregion
5068276AU04724314582824289928243044Ratregion
5064162AW52964915182886630328866454Ratregion
5064212BI29638716383007956730079730Ratregion
5066292PMC139861P163683067768130678317Ratregion
5064830BF40518911683066638730666503Ratregion
5082021BF41565716882859015228590321Ratregion
5089349AU04910326282967286829673132Ratregion
5083547BE10052615483072357130723725Ratregion
5087185BM38790817783031677930316956Ratregion
5089247AU04904316082827366728273829Ratregion
5507099UniSTS:22452715582839091328391068Ratregion
5500194SHGC-15200358883030771830308306Ratregion
5501313ECD1447749282837107228371564Ratregion
5501966MARC_21333-21334:1023126386:116682962849129629431Ratregion
5507327GDB:192496082994361229943758Ratregion
Position Markers

Flank 1: (D8Mit5)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2830,848,154 - 30,848,259 (+)MAPPER
Rnor_6.0833,558,660 - 33,558,764NCBI
Rnor_5.0833,603,024 - 33,603,128UniSTS
RGSC_v3.4832,203,395 - 32,203,499UniSTS
RGSC_v3.4832,203,394 - 32,203,499RGD
RGSC_v3.1832,212,161 - 32,212,265RGD
Celera832,299,483 - 32,299,583UniSTS
RH 3.4 Map8248.5UniSTS
RH 3.4 Map8248.5RGD
RH 2.0 Map8167.4RGD
Cytogenetic Map8q21UniSTS
Peak: (D8Rat162)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2829,502,665 - 29,502,918 (+)MAPPER
Rnor_6.0832,201,981 - 32,202,233NCBI
Rnor_5.0832,227,585 - 32,227,837UniSTS
RGSC_v3.4830,878,636 - 30,878,889RGD
RGSC_v3.4830,878,637 - 30,878,889UniSTS
RGSC_v3.1830,887,403 - 30,887,655RGD
Celera830,964,403 - 30,964,657UniSTS
RH 3.4 Map8246.2UniSTS
RH 3.4 Map8246.2RGD
SHRSP x BN Map821.82UniSTS
SHRSP x BN Map821.82RGD
Cytogenetic Map8q13UniSTS
Flank 2: (D8Rat130)
Rat AssemblyChrPosition (strand)Source
Rnor_5.08100,888,495 - 100,888,674NCBI
RGSC_v3.4898,986,085 - 98,986,263RGD
RGSC_v3.1899,005,540 - 99,005,718RGD
SHRSP x BN Map857.2699RGD
SHRSP x BN Map857.2699UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)82815732330848259Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83084815440713225Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Uae8

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general SS allele associated with increased urinary albumin excretion, highest at 12 weeks of age; at older age stage also linked to elevated urinary protein excretion (UPE) (LOD = 6.0) 634617