Eae15 QTL Report (Rattus norvegicus)

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QTL Registration

General

QTL: Eae15 (Experimental allergic encephalomyelitis QTL 15) Rattus norvegicus

Symbol:

Eae15

Name:

Experimental allergic encephalomyelitis QTL 15

RGD ID:

70172

Also known as:

Experimental (autoimmune) encephalomyelitis QTL 15

Trait:

nervous system integrity trait (VT:0010566)

Measurement Type:

experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)

LOD Score:

Not Available

P Value:

0.001

Variance:

Not Available

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	18	79,948,616 - 80,696,375	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	18	79,012,526 - 79,748,387	RGD	Rnor5.0
RGSC_v3.4	18	79,585,008 - 80,370,517	RGD	RGSC3.4
RGSC_v3.1	18	79,658,281 - 80,444,102	RGD

Cross Type:

Strains Crossed:

ACI/N DA

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Autoimmune Encephalomyelitis (IDA)

multiple sclerosis (IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

demyelination (QTM)

increased inflammatory response (QTM)

paresis (QTM)

Experimental Data Annotations Click to see Annotation Detail View

Clinical Measurement

experimental autoimmune encephalomyelitis incidence/prevalence measurement (IDA)

Experimental Condition

Freund's incomplete adjuvant (IDA)

myelin oligodendrocyte glycoprotein (IDA)

Measurement Method

enzyme linked immunosorbent assay (IDA)

Vertebrate Trait

nervous system integrity trait (IDA)

Rat Strain

ACI/N (IEA)

DA (IEA)

References

References - curated


1.	Dahlman I, etal., Hum Mol Genet 1999 Nov;8(12):2183-90.
2.	QTL data import from the RatMap database

Region

Genes in Region

The following Genes overlap with this region.

RGD ID	Symbol	Name	Chr	Start	Stop	Species
7650944	LOC102552643	uncharacterized LOC102552643	18	80118854	80123326	Rat
7738973	LOC102552707	uncharacterized LOC102552707	18	80329287	80347482	Rat
9293028	LOC103694252	uncharacterized LOC103694252	18	80294242	80305780	Rat
11486830	LOC108348864	uncharacterized LOC108348864	18	80487980	80495802	Rat

Markers in Region

The following Markers overlap with this region.

RGD ID	Symbol	Expected Size	Chr	Start	Stop	Species	Match
33814	D18Mit9	180	18	80696226	80696375	Rat	region
34290	D18Mgh4	126	18	79948616	79948741	Rat	region
39904	D18Rat78	201	18	80012073	80012283	Rat	region
45519	D18Got70	186	18	80179200	80179385	Rat	region
45522	D18Got67	224	18	80404881	80405104	Rat	region
45528	D18Got69	239	18	80696219	80696456	Rat	region
629590	D18Hmgc1	142	18	79999421	79999552	Rat	region
1636968	D18M18Mit1	158	18	80567794	80567951	Rat	region
5506863	G46819	230	18	80624314	80624543	Rat	region
5500167	D18Mit216	611	18	80228553	80229163	Rat	region

Position Markers

Flank 1: (D18Mgh4)

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	79,948,616 - 79,948,741	NCBI
Rnor_5.0	18	79,012,526 - 79,012,652	NCBI
Rnor_5.0	18	79,012,527 - 79,012,652	UniSTS
RGSC_v3.4	18	79,585,008 - 79,585,133	UniSTS
RGSC_v3.1	18	79,658,281 - 79,658,406	RGD
Celera	18	75,108,134 - 75,108,259	UniSTS
RH 3.4 Map	18	813.5	UniSTS
RH 3.4 Map	18	813.5	RGD
RH 2.0 Map	18	44.4	RGD

Peak: (D18Mit6)

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	83,366,257 - 83,366,399	NCBI
Rnor_5.0	18	82,427,608 - 82,427,750	UniSTS
RGSC_v3.4	18	82,920,380 - 82,920,522	UniSTS
RGSC_v3.4	18	82,920,379 - 82,920,522	RGD
RGSC_v3.1	18	82,993,830 - 82,993,972	RGD
Celera	18	78,116,960 - 78,117,102	UniSTS
Cytogenetic Map	18	q13	UniSTS
RH 3.4 Map	18	768.3	RGD
RH 3.4 Map	18	768.3	UniSTS
SHRSP x BN Map	18	51.2799	UniSTS
SHRSP x BN Map	18	51.2799	RGD

Flank 2: (D18Mit9)

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	80,696,226 - 80,696,375	NCBI
Rnor_5.0	18	79,748,238 - 79,748,387	UniSTS
RGSC_v3.4	18	80,370,368 - 80,370,517	UniSTS
RGSC_v3.4	18	80,370,367 - 80,370,517	RGD
RGSC_v3.1	18	80,443,810 - 80,444,102	RGD
Celera	18	75,835,913 - 75,836,062	UniSTS
Cytogenetic Map	7	q36	UniSTS
RH 3.4 Map	18	814.4	UniSTS
RH 3.4 Map	18	814.4	RGD
RH 2.0 Map	18	53.0	RGD
SHRSP x BN Map	18	49.0499	RGD
FHH x ACI Map	18	60.7699	RGD

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	15695872	87080053	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	15695872	87080053	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	20285758	87080053	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	22603736	87074531	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25961026	81761656	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	32670352	87080053	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	32704022	80696226	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	38221919	83221919	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	40375769	85375769	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	45002194	88201929	Rat
1598826	Anxrr20	Anxiety related response QTL 20	3.04		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	18	46319476	88201929	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	49130920	88201929	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	49130920	88201929	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	49130920	88201929	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	51375816	88201929	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	51375816	88201929	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	53033494	87080053	Rat
1558649	Bw58	Body weight QTL 58	3.4	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	18	57448678	88201929	Rat
6893359	Bw103	Body weight QTL 103	1.2	0.12	body mass (VT:0001259)	body weight (CMO:0000012)	18	57448678	88201929	Rat
6893368	Bw107	Body weight QTL 107	0.3	0.5	body mass (VT:0001259)	body weight (CMO:0000012)	18	57448678	88201929	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	58196300	88201929	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61901354	79948616	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	61901354	79948616	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	18	61901354	79948616	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	18	61901354	79948616	Rat
2301969	Bp324	Blood pressure QTL 324	4.05		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	61901354	79948616	Rat
6903356	Bp354	Blood pressure QTL 354	4.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	61985648	88201929	Rat
631675	Iddm15	Insulin dependent diabetes mellitus QTL 15			urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	18	62805406	80696375	Rat
61384	Bp48	Blood pressure QTL 48	19.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	62805406	80696375	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	63009812	88201929	Rat
634333	Pia19	Pristane induced arthritis QTL 19	3.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	77151301	83366399	Rat
70172	Eae15	Experimental allergic encephalomyelitis QTL 15		0.001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	18	79948616	80696375	Rat

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Eae15

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-08	Eae15	Experimental allergic encephalomyelitis QTL 15		Experimental (autoimmune) encephalomyelitis QTL 15	Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
qtl_statistics_details	QTL is also significant for CNS inflammation (P = 0.0023) and paresis (P = 0.013)	69695

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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