Eae15 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Eae15 (Experimental allergic encephalomyelitis QTL 15) Rattus norvegicus

Symbol: Eae15
Name: Experimental allergic encephalomyelitis QTL 15
RGD ID: 70172
Previously known as: Experimental (autoimmune) encephalomyelitis QTL 15
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: experimental autoimmune encephalomyelitis incidence/prevalence measurement   (CMO:0001046)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21876,477,814 - 77,209,844RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01879,948,616 - 80,696,375RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01879,012,526 - 79,748,387RGDRnor5.0
RGSC_v3.41879,585,008 - 80,370,517RGDRGSC3.4
RGSC_v3.11879,658,281 - 80,444,102RGD
Cross Type: F2
Strains Crossed: ACI/N DA 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
ACI/N  (IEA)
DA  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18. Dahlman I, etal., Hum Mol Genet 1999 Nov;8(12):2183-90.
2. QTL Data Transfer QTL data import from the RatMap database

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
7738973LOC102552707uncharacterized LOC102552707187682367776880809Rat
41132170LOC120098409U1 spliceosomal RNA187670122976701384Rat
40981657LOC120098250uncharacterized LOC120098250187672163776731166Rat
41050242LOC120098191uncharacterized LOC120098191187686848276900985Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33814D18Mit9180187720969477209844Ratregion
34290D18Mgh4126187647781476477940Ratregion
39904D18Rat78201187654164076541851Ratregion
45519D18Got70186187670964076709826Ratregion
45522D18Got67224187693902976939253Ratregion
45528D18Got69239187720968777209925Ratregion
629590D18Hmgc1142187652910676529238Ratregion
1636968D18M18Mit1158187712681077126968Ratregion
5506863G46819230187713730277137532Ratregion
5500167D18Mit216611187675908876759699Ratregion
Position Markers

Flank 1: (D18Mgh4)
Rat AssemblyChrPosition (strand)Source
mRatBN7.26118,921,813 - 118,921,891 (-)MAPPER
mRatBN7.21876,477,814 - 76,477,940 (+)MAPPER
Rnor_6.01879,948,616 - 79,948,741NCBI
Rnor_5.01879,012,527 - 79,012,652UniSTS
Rnor_5.01879,012,526 - 79,012,652NCBI
RGSC_v3.41879,585,008 - 79,585,133UniSTS
RGSC_v3.11879,658,281 - 79,658,406RGD
Celera1875,108,134 - 75,108,259UniSTS
RH 3.4 Map18813.5RGD
RH 3.4 Map18813.5UniSTS
RH 2.0 Map1844.4RGD
Peak: (D18Mit6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21879,531,886 - 79,532,029 (+)MAPPER
Rnor_6.01883,366,257 - 83,366,399NCBI
Rnor_5.01882,427,608 - 82,427,750UniSTS
RGSC_v3.41882,920,379 - 82,920,522RGD
RGSC_v3.41882,920,380 - 82,920,522UniSTS
RGSC_v3.11882,993,830 - 82,993,972RGD
Celera1878,116,960 - 78,117,102UniSTS
RH 3.4 Map18768.3UniSTS
RH 3.4 Map18768.3RGD
SHRSP x BN Map1851.2799UniSTS
SHRSP x BN Map1851.2799RGD
Cytogenetic Map18q13UniSTS
Flank 2: (D18Mit9)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21877,209,694 - 77,209,844 (+)MAPPER
Rnor_6.01880,696,226 - 80,696,375NCBI
Rnor_5.01879,748,238 - 79,748,387UniSTS
RGSC_v3.41880,370,367 - 80,370,517RGD
RGSC_v3.41880,370,368 - 80,370,517UniSTS
RGSC_v3.11880,443,810 - 80,444,102RGD
Celera1875,835,913 - 75,836,062UniSTS
RH 3.4 Map18814.4UniSTS
RH 3.4 Map18814.4RGD
RH 2.0 Map1853.0RGD
SHRSP x BN Map1849.0499RGD
FHH x ACI Map1860.7699RGD
Cytogenetic Map7q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
634333Pia19Pristane induced arthritis QTL 193.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)187399714079532029Rat
70172Eae15Experimental allergic encephalomyelitis QTL 150.001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)187647781477209844Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Eae15


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-08 Eae15  Experimental allergic encephalomyelitis QTL 15    Experimental (autoimmune) encephalomyelitis QTL 15  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
qtl_statistics_details QTL is also significant for CNS inflammation (P = 0.0023) and paresis (P = 0.013) 69695