Niddm12 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Niddm12 (Non-insulin dependent diabetes mellitus QTL 12) Rattus norvegicus

Symbol: Niddm12
Name: Non-insulin dependent diabetes mellitus QTL 12
RGD ID: 61466
Previously known as: Nidd/gk6
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: plasma glucose level   (CMO:0000042)    
LOD Score: 3.2
P Value: 0.001
Variance: 11.0
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21754,029,929 - 60,463,637RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01760,397,177 - 63,994,347RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01762,181,621 - 65,757,413RGDRnor5.0
RGSC_v3.41760,586,065 - 71,214,851RGDRGSC3.4
RGSC_v3.11760,596,898 - 71,225,684RGD
Cross Type: F2
Strains Crossed: GK/KyoSwe BN 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition
fasting  (IDA)

Measurement Method

Vertebrate Trait

Rat Strain
BN  (IEA)
GK/KyoSwe  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat Gauguier D, etal., Nat Genet 1996 Jan;12(1):38-43

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2402CremcAMP responsive element modulator175423888954305989Rat
2343Chrm3cholinergic receptor, muscarinic 3176000513760467250Rat
620314Ryr2ryanodine receptor 2175838992558975641Rat
628708Zp4zona pellucida glycoprotein 4175900564959012202Rat
621283Mtr5-methyltetrahydrofolate-homocysteine methyltransferase175821999858308560Rat
621272Lgals8galectin 8175802465258052764Rat
621831BambiBMP and activin membrane-bound inhibitor175412125154125816Rat
628621Gjd4gap junction protein, delta 4175734884457352601Rat
1305652Mkxmohawk homeobox175507707355156877Rat
1308097Actn2actinin alpha 2175814333458210622Rat
1308905Rab18RAB18, member RAS oncogene family175494409954976093Rat
1305675Mpp7MAGUK p55 scaffold protein 7175543993955706810Rat
1306933Odad2outer dynein arm docking complex subunit 2175521687755409872Rat
1310644Cul2cullin 2175416909354210197Rat
1565969Ccnycyclin Y175738500257512860Rat
1562407WacWW domain containing adaptor with coiled-coil175592268655984286Rat
1566097Anlnl1anillin, actin binding protein-like 1175798534057995824Rat
15641294930596D02Rikl2RIKEN cDNA 4930596D02 gene like 2175415157254154198Rat
1564769Heatr1HEAT repeat containing 1175805328858093895Rat
1560525Fzd8frizzled class receptor 8175731292457320551Rat
1586418Snrpnl1small nuclear ribonucleoprotein polypeptide N like 1175637209656373049Rat
1586431Rpl11-ps8ribosomal protein L11, pseudogene 8175617739356231616Rat
1586445Hspa8-ps22heat shock protein family A (Hsp70) member 8, pseudogene 22175613329856135340Rat
1586464Ddx5-ps3DEAD-box helicase 5, pseudogene 3175606927856070533Rat
1589973Nsa2-ps11NSA2 ribosome biogenesis factor, pseudogene 11175962502059625946Rat
15608604921524L21RiklRIKEN cDNA 4921524L21 gene like175480818454847675Rat
1589709Nsfl1c-ps1NSFL1 cofactor, pseudogene 1175705725957058451Rat
1589711Rps14-ps4ribosomal protein S14, pseudogene 4175490401954904610Rat
1589712Hdac1-ps12Histone deacetylase 1, pseudogene 12175441745054419389Rat
1585457Ralgdsl8ral guanine nucleotide dissociation stimulator like 8175480056554808145Rat
1593823Psme1l1proteasome activator subunit 1 like 1175529762755298808Rat
2324280Epc1enhancer of polycomb homolog 1175450335854594444Rat
2323728Snurf-ps2SNRPN upstream open reading frame, pseudogene 2175637209656373411Rat
6501948LOC100909729uncharacterized LOC100909729175751315957514759Rat
6498435Mki67-ps1marker of proliferation Ki-67, pseudogene 1175441415554415827Rat
7544805LOC102553208ral guanine nucleotide dissociation stimulator-like175478059154783184Rat
9098363LOC103694114DNA repair protein RAD51 homolog 1 pseudogene175669436556695323Rat
9147085Fam95cfamily with sequence similarity 95 member C175468104054721106Rat
9152346LOC103690071interaptin-like175762154257900975Rat
9472036PotedPOTE ankyrin domain family member D175794212457975149Rat
11359972LOC108348578uncharacterized LOC108348578175423139954239004Rat
11403554LOC10834857760S ribosomal protein L29 pseudogene175418631254187090Rat
41139904LOC120097995small nucleolar RNA SNORA17175621668056216814Rat
41125104LOC120097928SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5-like175827429558278695Rat
41156892LOC120097906uncharacterized LOC120097906175913071959138035Rat
41289469LOC120097863ral guanine nucleotide dissociation stimulator-like175474578054748331Rat
41373608LOC120097886ral guanine nucleotide dissociation stimulator-like175466487154667458Rat
41377181LOC120097915uncharacterized LOC120097915175824370458247835Rat
40985311Trnaa-agc37transfer RNA alanine (anticodon AGC) 37175719764257197722Rat
41243501LOC120097813uncharacterized LOC120097813175933758259355633Rat
41319530LOC120097781ral guanine nucleotide dissociation stimulator-like175472078054728358Rat
41332867LOC120098026small nucleolar RNA U3175842230958422433Rat
41054517Trnas-aga47transfer RNA serine (anticodon AGA) 47175819156958191644Rat
41151572LOC120098020U2 spliceosomal RNA175541452255414611Rat
41152666Ddx5-ps1DEAD-box helicase 5, pseudogene 1175524545455259642Rat
41267736Rps7-ps15ribosomal protein S7, pseudogene 15175832060758324029Rat
41063315LOC120098009small Cajal body-specific RNA 20175582035855820490Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10348D17Mit4215176046341260463643Ratregion
10349D17Arb7221176046340560463642Ratregion
10350D17Wox12121176046350060463637Ratregion
10351D17Wox13134176046348360463633Ratregion
33860D17Mit10231175523786855238103Ratregion
36329D17Rat32126175583607655836425Ratregion
36329D17Rat32126175583630655836425Ratregion
36996D17Rat31162175683672856836890Ratregion
37762D17Rat170170175949767959497857Ratregion
34821D17Rat56128175648264756482769Ratregion
35052D17Rat33126176011018860110323Ratregion
35062D17Rat30170175812456458124741Ratregion
40400D17Rat148143175803800658038147Ratregion
38780D17Rat64135175558322555583355Ratregion
40114D17Rat122125176000088060000997Ratregion
40198D17Rat123168175876879458768965Ratregion
38798D17Rat150220175801245258012678Ratregion
42045D17Arb5127175869183558691962Ratregion
42418D17Rat68171175863292958633100Ratregion
43098D17Rat149133175816531158165446Ratregion
45480D17Got79108175881625858816366Ratregion
45481D17Got77108175854148258541590Ratregion
45482D17Got75218175996373459963952Ratregion
45484D17Got74195176001893760019130Ratregion
45485D17Wox9108175724672357246843Ratregion
60772D17Wox4162175813056958130741Ratregion
60152D17Got66179175403232454032503Ratregion
60153D17Got67225175409256754092794Ratregion
60154D17Got69196175473390454734092Ratregion
60156D17Got71144175793532457935468Ratregion
60156D17Got71144175793532457935468Ratregion
60157D17Got72269175648264756482916Ratregion
60158D17Got73269175623448356234752Ratregion
625794D17Got12598175442144154421539Ratregion
61300D17Mco3259175955501359555289Ratregion
1556757D17Chm26241175589768755897924Ratregion
1635830D17Uwm3166175692621756926383Ratregion
7205844Ddx50175524549555246484Ratregion
5038724AA93023279175427528154275360Ratregion
5038726AW04837697175738158457381681Ratregion
5039010RH127461180175598408255984262Ratregion
5028629RH124435278175805806058058338Ratregion
7206236Fzd882175731770057317782Ratregion
5031690AU047474241175760185857602099Ratregion
5029510AI556320201175430366954303870Ratregion
5027119RH70526130175944187759442007Ratregion
5033159RH137808176175512602155126197Ratregion
502787519.MMHAP16FRG7.seq183175691302956913212Ratregion
5028318D10S1559125175598164855981773Ratregion
5028318D10S1559125175598164855981773Ratregion
5028499AI503754101175434517154345273Ratregion
5028567C76891232175789663457896866Ratregion
5028567C76891232175789663457896866Ratregion
5055083RH143596165175834096158341126Ratregion
5055971RH144108157175595779755957954Ratregion
5056751RH144559173175536049955360672Ratregion
5056465RH144394240175751447757514718Ratregion
5050500RH134092186175415401354154198Ratregion
5050586RH134141164175821329858213462Ratregion
5051711RH94613101175430301654303116Ratregion
5045974RH131486217175897533058975547Ratregion
5048780RH133101187175544014855440335Ratregion
5047426RH132321190175521923955219429Ratregion
5042584RH129523210175503230855032525Ratregion
5039572RH127782200175497580154976001Ratregion
5040538RH128341206175738139057381596Ratregion
5074908RH138288129175521572455215853Ratregion
5074104RH137824139175496197054962109Ratregion
5075336RH138536164175430424154304405Ratregion
5073222RH137311180175738484357385023Ratregion
5066928AU048067296175536897755369274Ratregion
5067416AU047762134175558319555583329Ratregion
5069444AU046494216175473390254734105Ratregion
5064322BE114408171175497844954978620Ratregion
5061476BE111848159175731299857313157Ratregion
5086327BM386345154175505407455054228Ratregion
5082465BE119488188175497620654976394Ratregion
5087283AW531528186175817987458180060Ratregion
5089281AU049062188175979416959794357Ratregion
5090103AU049552248175876877858769026Ratregion
5081230RH142039166175731804557318211Ratregion
5083227BI275488109175427568654275795Ratregion
5083767AI598891105175416915254169257Ratregion
5503076Actn2121175817097158172160Ratregion
5503821MARC_33810-33811:1053549243:1283175451715454517437Ratregion
5507699GDB:131819860175428260354282663Ratregion
5504718PMC84149P1396175439776454398162Ratregion
5504887ha30461560175742191857423478Ratregion
5504999Fzd8155175731681457316969Ratregion
5504472PMC21940P1246175897512058975366Ratregion
5507129UniSTS:224716174175430307754303251Ratregion
5507271fc41h02.x1817175992373059924675Ratregion
5507287fb54b04.x10176000564260006974Ratregion
5507287fb54b04.x10176000564260006996Ratregion
5500951MARC_9759-9760:996688576:1309175490413854904449Ratregion
5500793stSG625620867175930361859304485Ratregion
5501436Snrpn358175637213156372489Ratregion
5505530A005N471694175787883057880524Ratregion
Position Markers

Flank 1: (D17Wox12)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21760,463,500 - 60,463,637 (-)MAPPER
Rnor_6.01763,994,211 - 63,994,347NCBI
Rnor_5.01765,757,277 - 65,757,413UniSTS
RGSC_v3.41771,214,714 - 71,214,851RGD
RGSC_v3.41771,214,715 - 71,214,851UniSTS
RGSC_v3.11771,225,547 - 71,225,684RGD
Celera1760,112,968 - 60,113,104UniSTS
RH 3.4 Map17559.0UniSTS
RH 3.4 Map17559.0RGD
RH 2.0 Map17514.1RGD
Cytogenetic Map17q12.1UniSTS
Peak: (D17Wox9)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21757,246,723 - 57,246,843 (+)MAPPER
Rnor_6.01762,195,703 - 62,195,822NCBI
Rnor_5.01763,969,458 - 63,969,577UniSTS
RGSC_v3.41765,900,398 - 65,900,518RGD
RGSC_v3.41765,900,399 - 65,900,518UniSTS
RGSC_v3.11765,911,232 - 65,911,351RGD
Celera1758,532,268 - 58,532,375UniSTS
RH 3.4 Map17588.6UniSTS
RH 3.4 Map17588.6RGD
RH 2.0 Map17510.6RGD
Cytogenetic Map17 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)175724672370852846Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)175402992960463637Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Niddm12


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-18 Niddm12  Non-insulin-dependent diabetes mellitus QTL 12      Symbol and Name updated 61033 APPROVED
2002-07-18 Nidd/gk6  Non-insulin-dependent diabetes mellitus GK QTL 6      Symbol and Name withdrawn 61033 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercorss  
qtl_general also may link to body weight (LOD=2.4) but does not link to adiposity index 61061