Ciaa1 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Ciaa1 (CIA Autoantibody QTL 1) Rattus norvegicus

Symbol: Ciaa1
Name: CIA Autoantibody QTL 1
RGD ID: 61448
Trait: blood autoantibody amount   (VT:0003725)    
Measurement Type: calculated serum anti-rat type 2 collagen autoantibody titer   (CMO:0001281)    
LOD Score: 30.0
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,646,395 - 4,597,031RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0203,151,815 - 6,896,013RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0205,249,981 - 8,621,883RGDRnor_5.0
RGSC_v3.4202,790,511 - 4,530,895RGDRGSC_v3.4
RGSC_v3.1202,790,738 - 4,531,120RGD
Cross Type: F2
Strains Crossed: BN DA 



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
BN  (IEA)
DA  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
2. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
3. Quest for arthritis-causative genetic factors in the rat. Joe B Physiol Genomics. 2006 Oct 3;27(1):1-11. Epub 2006 Jun 27.
4. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. Kawahito Y, etal., J Immunol 1998 Oct 15;161(8):4411-9
5. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
6. The complexity in hunting for candidate genes within QTL that determine susceptibility to arthritis in rats. Xiong Q, etal., Crit Rev Immunol. 2008;28(2):127-57.
7. Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms. Xiong Q, etal., J Immunol. 2008 Jul 15;181(2):859-64.
Related QTLs

Related QTL Description Reference
Aia1 interacts with RGD:61035
Oia1 maps to same region RGD:61066
Cia1 interacts with RGD:61066


Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Flank 1: (D20Arb2)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2202,666,495 - 2,666,654 (+)MAPPER
mRatBN7.2202,646,395 - 2,646,556 (+)MAPPER
Rnor_6.0203,151,815 - 3,151,975NCBI
Rnor_6.0203,171,911 - 3,172,069NCBI
Rnor_5.0205,270,077 - 5,270,235UniSTS
Rnor_5.0205,249,981 - 5,250,141UniSTS
RGSC_v3.4202,790,512 - 2,790,672UniSTS
RGSC_v3.4202,811,408 - 2,811,567RGD
RGSC_v3.4202,790,511 - 2,790,672RGD
RGSC_v3.4202,811,409 - 2,811,567UniSTS
Celera2076,870 - 77,030UniSTS
Celera2096,911 - 97,069UniSTS
RGSC_v3.1202,790,738 - 2,790,899RGD
SHRSP x BN Map200.0RGD
SHRSP x BN Map200.0UniSTS
FHH x ACI Map200.16RGD
Peak: (D20Wox3)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2203,621,656 - 3,621,771 (+)MAPPER
mRatBN7.2203,621,656 - 3,621,771 (-)MAPPER
Rnor_6.0205,192,240 - 5,192,354NCBI
Rnor_6.0204,855,475 - 4,855,589NCBI
Rnor_5.0206,935,875 - 6,935,989UniSTS
RGSC_v3.4203,660,646 - 3,660,760UniSTS
Celera204,403,718 - 4,403,832UniSTS
RGSC_v3.1203,660,872 - 3,660,987RGD
Cytogenetic Map20p12UniSTS
Flank 2: (D20Arb8)
Rat AssemblyChrPosition (strand)Source
Cytogenetic Map20 RGD


Additional Information

Database Acc Id Source(s)
NCBI Gene Ciaa1

RGD Curation Notes
Note Type Note Reference
qtl_gene whole genome analysis using PGMapper revealed Tnf, Mif, Tap2, Tap1, Hla-dma, Hla-dmb, Nfkbil1 as RA associated genes and Tnf, Mif, Tap2, Tap1, Hla-dma, Hla-dmb, Nfkbil1 as RA associated polymorphism either in coding or regulatory region 2300074
qtl_gene 205 known and 24 novel genes were found in an analysis based on PubMed and OMIM data 2307198
qtl_general significant change in LOD scores between sexes; females LOD= 27.9, males LOD=14.2 61067
qtl_general trait-specific allele contributed by hte BB/DR parent 61067