Rf1 QTL Report (Rattus norvegicus) - Rat Genome Database
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QTL: Rf1 (Renal disease susceptibility QTL 1) Rattus norvegicus

Symbol: Rf1
Name: Renal disease susceptibility QTL 1
RGD ID: 61345
Also known as: Rf-1
Trait: urine protein amount   (VT:0005160)    
Measurement Type: urine protein excretion rate   (CMO:0000759)    
LOD Score: 8.9
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01225,717,037 - 270,717,037RGDRnor5.0
RGSC_v3.41202,322,277 - 247,322,277RGDRGSC3.4
RGSC_v3.11202,436,752 - 247,436,752RGD
Cross Type: (FHH x ACI) x FHH Backcross
Strains Crossed: ACI/N FHH/Eur 



Candidate Gene Status
Got1 is a candidate Gene for Rf1
Slk is a candidate Gene for Rf1
Hps1 is a candidate Gene for Rf1
Arl3 is a candidate Gene for Rf1
Cpn1 is a candidate Gene for Rf1
Pi4k2a is a candidate Gene for Rf1
Sfxn3 is a candidate Gene for Rf1
Oga is a candidate Gene for Rf1
As3mt is a candidate Gene for Rf1
Nolc1 is a candidate Gene for Rf1
Avpi1 is a candidate Gene for Rf1

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait

Rat Strain
ACI/N  (IEA)
FHH/Eur  (IEA)

References


Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Flank 1: (D1Mit6)
Rat AssemblyChrPosition (strand)Source
Cytogenetic Map1 RGD
Flank 2: (D1Mgh12)
Rat AssemblyChrPosition (strand)Source
Rnor_5.01270,716,905 - 270,717,037NCBI
RGSC_v3.41247,322,146 - 247,322,277RGD
RGSC_v3.11247,436,621 - 247,436,752RGD
Celera1238,204,080 - 238,204,181UniSTS
Cytogenetic Map1q54UniSTS
RH 3.4 Map11616.91UniSTS
RH 3.4 Map11616.91RGD
RH 2.0 Map11221.1RGD
SHRSP x BN Map1133.51RGD


Additional Information

Database Acc Id Source(s)
NCBI Gene Rf1

RGD Curation Notes
Note Type Note Reference
qtl_cross_type (FHH x ACI) x FHH Backcross  
qtl_gene 66 candidate disease genes have been identified using a combination of EST alignments to the rat 1q43-54 genomic sequence, comparison with syntenic human sequence and end stage renal disease (ESRD) region, analysis of human homologs, and expression data. 1299961
qtl_general also confirmed by the generation of the congenic strain ACI.FHH-(D1Mit34-D1Rat156) 625641
qtl_map syntenic to a human chromosome 10 end-stage renal disease (ESRD) QTL 1299961
qtl_statistics_details also significant for urine protein level, mainly consisting of albuminuria, (LOD = 16.9, variance = 19.6%) and focal glomerulosclerosis (LOD score = 8.6, variance = 14.2%), and suggestive for systolic blood pressure (LOD = 2.7) 70856