Eae8 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Eae8 (Experimental allergic encephalomyelitis QTL 8) Rattus norvegicus

Symbol: Eae8
Name: Experimental allergic encephalomyelitis QTL 8
RGD ID: 61328
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: percentage of study population developing experimental autoimmune encephalomyelitis during a period of time   (CMO:0001047)    
LOD Score: 4.0
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,816,041 - 33,061,905RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01924,457,627 - 37,140,233RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01935,435,631 - 48,006,398RGDRnor5.0
RGSC_v3.41926,534,809 - 34,998,604RGDRGSC3.4
RGSC_v3.11926,539,634 - 35,003,485RGD
Cross Type: F2
Strains Crossed: DA E3 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
paresis  (QTM)
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
DA  (IEA)
E3  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis. Bergsteinsdottir K, etal., J Immunol 2000 Feb 1;164(3):1564-8
2. The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis. Wernhoff P, etal., Arthritis Rheum. 2003 Dec;48(12):3584-96.
Related QTLs

Related QTL Description Reference
Pia34 maps to same region RGD:2302026


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3094Nr3c2nuclear receptor subfamily 3, group C, member 2193071564831059885Rat
2535Ednraendothelin receptor type A193023354030303727Rat
3931Ucp1uncoupling protein 1192480878224816853Rat
3030Smad1SMAD family member 1192851313028573665Rat
2887Il15interleukin 15192564001325706818Rat
620075Pou4f2POU class 4 homeobox 2192948668629490327Rat
620493Cbfbcore-binding factor subunit beta193304916233092752Rat
620470Inpp4binositol polyphosphate-4-phosphatase type II B192592018926670085Rat
1304572Rnf150ring finger protein 150192500697825229273Rat
1307418Ces4acarboxylesterase 4A193301173133030119Rat
1307510Zfp330zinc finger protein 330192531365525324958Rat
1306751Rbmxl1Rbmx like 1192940790229411519Rat
1305606Otud4OTU deubiquitinase 4192823671328279815Rat
1305035Mmaametabolism of cobalamin associated A192861906028649319Rat
1311085Gab1GRB2-associated binding protein 1192713126227239236Rat
1308936Anapc10anaphase promoting complex subunit 10192815229928205552Rat
1308358Ces2gcarboxylesterase 2G193294674832954337Rat
1311974Usp38ubiquitin specific peptidase 38192700604627037449Rat
727852Tmem184ctransmembrane protein 184C193034518330361275Rat
1308221Tbc1d9TBC1 domain family member 9192484216624951383Rat
1305301Abce1ATP binding cassette subfamily E member 1192820556628230489Rat
1308832Smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5192727191827304594Rat
1306157Prmt9protein arginine methyltransferase 9193037634230414491Rat
1562701Frem3FRAS1 related extracellular matrix 3192730846927366771Rat
1561806LOC498933LOC498933192866905928704512Rat
1561937Lsm6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated192909825429112858Rat
1564100Rasd2-ps1RASD family, member 2, pseudogene 1193292245832923087Rat
1560889Ces2hcarboxylesterase 2H193297424232988842Rat
1560620Zfp827zinc finger protein 827192872056828887381Rat
1587307Eif2s1-ps2eukaryotic translation initiation factor 2 subunit alpha, pseudogene 2192541230925413479Rat
1583003Rpl35-ps11ribosomal protein L35, pseudogene 11192712109727121489Rat
1564108HhipHedgehog-interacting protein192786368427952528Rat
1561851Slc25a36l1solute carrier family 25 (pyrimidine nucleotide carrier ), member 36-like 1193294152332943368Rat
1582935Gypaglycophorin A192745031127465940Rat
1565102Rps15-ps8ribosomal protein S15, pseudogene 8192664190526650112Rat
1564388Slc10a7solute carrier family 10, member 7192918314329407470Rat
1587348Nsa2-ps15NSA2 ribosome biogenesis factor, pseudogene 15193003515830035929Rat
1589777Ttc29tetratricopeptide repeat domain 29192953170729750635Rat
1592274Ap3s1-ps2adaptor related protein complex 3 subunit sigma 1, pseudogene 2192981927629820542Rat
1588826Rps27a-ps6ribosomal protein S27a, pseudogene 6193091627930916833Rat
1589885Myl6b-ps1myosin light chain 6B, pseudogene 1193282713532827751Rat
1589916LOC689662hypothetical protein LOC689662193199233732204030Rat
1588859Arhgap10Rho GTPase activating protein 10193044857230710315Rat
1590923Hsp90ab1-ps2heat shock protein 90 alpha family class B member 1, pseudogene 2193243005232433227Rat
1585295LOC688712similar to ribosomal protein L22 like 1192542082225421388Rat
1588734Ces3acarboxylesterase 3a193299238633000562Rat
1597608Gapdh-ps8Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 8192835548328356270Rat
2322909Mrps36-ps3mitochondrial ribosomal protein S36, pseudogene 3192849490828495203Rat
2322604Npm1-ps15nucleophosmin 1, pseudogene 15193212209332123262Rat
6495903Nt5c2-ps15'-nucleotidase, cytosolic II, pseudogene 1192841423828424767Rat
7614959LOC102548129acylcarnitine hydrolase-like193296512332970188Rat
7610034LOC102552779uncharacterized LOC102552779193028704930345197Rat
7610401LOC102553276uncharacterized LOC102553276193145524731487135Rat
7578796LOC102549584uncharacterized LOC102549584192805103528075585Rat
7549007LOC102549652uncharacterized LOC102549652192837776228385051Rat
7707469LOC102550010uncharacterized LOC102550010192865588228704532Rat
7690199LOC102554553uncharacterized LOC102554553192495274524958115Rat
7700714LOC10255066860S ribosomal protein L21-like192945683829457305Rat
9145556Smarce1-ps6SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 6192612829226131416Rat
9151310LOC103694973uncharacterized LOC103694973192761240027629804Rat
9299867LOC103694321uncharacterized LOC103694321193105760631130156Rat
11468429LOC108348925small nuclear ribonucleoprotein G pseudogene192821034428212718Rat
11474432LOC108348974uncharacterized LOC108348974192528969425301168Rat
11358650LOC108348918uncharacterized LOC108348918192490969324925713Rat
11435694LOC108353192uncharacterized LOC108353192193231488632561842Rat
11428350LOC108348923uncharacterized LOC108348923192542649525436109Rat
11450965LOC108348882histone H3.3-like193291050832922382Rat
11366551LOC108348983membrane-associated progesterone receptor component 1 pseudogene193051171630512578Rat
11442314Trnah-gug11transfer RNA histidine (anticodon GUG) 11193198233331982404Rat
11402022LOC10834888140S ribosomal protein S25 pseudogene192976874529769406Rat
41322043LOC120098577uncharacterized LOC120098577192892691528940920Rat
41112025LOC120098604uncharacterized LOC120098604192714050927149999Rat
41167744LOC120098738U4 spliceosomal RNA192914193029142070Rat
41343011LOC120098687small nucleolar RNA SNORA17193016270530162832Rat
41394269LOC120098734small nucleolar RNA U3193288980032889874Rat
41194492LOC120098746U6 spliceosomal RNA193303935833039455Rat
41160673Reeld1reeler domain containing 1192914189829159970Rat
41072776LOC120098703small nucleolar RNA SNORA17193082363230823744Rat
41402383LOC120098729U2 spliceosomal RNA192642919226429345Rat
41403740LOC120098694small nucleolar RNA SNORA17193192771031927841Rat
40944694Rpl28-ps5ribosomal protein L28, pseudogene 5192931088529316984Rat
40973828LOC120098602uncharacterized LOC120098602192717508827178216Rat
41014607LOC120098554uncharacterized LOC120098554192519944825209488Rat
40928770Dynlt1-ps2dynein light chain Tctex-type 1, pseudogene2193264733832647777Rat
40959505LOC120098688small nucleolar RNA SNORA17193303843133038569Rat
40991131LOC120098633uncharacterized LOC120098633192821608428220114Rat
40966524LOC120098594uncharacterized LOC120098594193019709130198483Rat
41316782LOC120098487uncharacterized LOC120098487192530601225313603Rat
41237132LOC120098673U7 small nuclear RNA193004933630049401Rat
41022843LOC120098735small nucleolar RNA U3193255065132550858Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
34033D19Mit5109193306179233061905Ratregion
11471D19Mit9149192481604124816202Ratregion
11472D19Wox8111192481797824818103Ratregion
33602D19Mit10183193108194131082124Ratregion
33741D15Mit4201192605267726052794Ratregion
35376D19Rat12178192570467125704884Ratregion
35881D19Rat11128192968965629689776Ratregion
38242D19Rat41161192629651126296662Ratregion
38298D19Rat48179192702113127021310Ratregion
38394D19Rat53121193297346832973603Ratregion
38808D19Rat54203192515071125150917Ratregion
39018D19Rat29206192932249029322676Ratregion
39300D19Rat40200193010343730103633Ratregion
39394D19Rat92201193281101932811220Ratregion
42428D19Rat124210192905967329059881Ratregion
41714D19Rat109126193006321930063337Ratregion
43131D19Rat120200192618261526182815Ratregion
43132D19Rat110227192735660227356819Ratregion
45606D19Got14168192843871428438882Ratregion
45607D19Got16158192849407628494234Ratregion
45609D19Got17157192849407628494234Ratregion
45610D19Got15156193046225130462407Ratregion
45611D19Got18132193177567731775809Ratregion
60781D19Wox3124192753020727530329Ratregion
60183D19Got19198192628389826284096Ratregion
1627722D19Ulb1158193106348431063642Ratregion
1629249D19Got105158192524194525242103Ratregion
1638597D19Got108199193068246030682659Ratregion
1632729D19Got116141192940606029406201Ratregion
1635840D19Got122210193108193031082139Ratregion
7206032Pou4f291192948771529487806Ratregion
7206558UniSTS:5470520193294218932943209Ratregion
5039296RH127625204192723874327238947Ratregion
5035554NR3C2248193105040631050654Ratregion
5031278PMC124545P1320193105071331051033Ratregion
5033899RH140541121192815306228153183Ratregion
5031568AU047895161192805742128057582Ratregion
5029063RH143375191192815363028153836Ratregion
5031832AU047006137192655126526551402Ratregion
5034442BE118125177192872106928721246Ratregion
5026488RH132403214192911201229112226Ratregion
5034764AI105420110193112965431129764Ratregion
5027365AI385626103192481661224816715Ratregion
5024962Smad1351192853969628540047Ratregion
502785913.MMHAP80FLE1.seq186192517150425171690Ratregion
502785913.MMHAP80FLE1.seq186192517150425171690Ratregion
5033327RH138429139192857303728573176Ratregion
5025330RH127903215193029675530296970Ratregion
5033375RH138607219192623674126236960Ratregion
5028293D8Mit162146192949547129495617Ratregion
5030909BI302228156192790026027900416Ratregion
5053775RH142844144192795235327952497Ratregion
5053925RH142930232192856948828569719Ratregion
5051957RH94757160192853952128539681Ratregion
5052412AI449692229192823682128237050Ratregion
5059750BE103144150192785984027859990Ratregion
5058214BF386808156192497624924976405Ratregion
5053351RH142598119192730865427308773Ratregion
5054385RH143194124192623682326236947Ratregion
5053379RH142614105193293952032939625Ratregion
5051747RH94635182192570662225706804Ratregion
5043552RH130090180193112700831127188Ratregion
5043866RH130273184193112700431127188Ratregion
5044144RH130435220192857322028573440Ratregion
5044160RH130444197193071581430716011Ratregion
5041898RH129122190192815234328152533Ratregion
5047430RH132323186192872073928720925Ratregion
5049692RH133626209192922616629226374Ratregion
5049592RH133569203192795896927959172Ratregion
5040224RH128161186193071007830710264Ratregion
5040438RH128283203192823009128230294Ratregion
5043044RH129796203192500040925000612Ratregion
5039792RH127909203192570645225706655Ratregion
7191220D19Mit9160192481604224816202Ratregion
5042882RH129701150192532474125324891Ratregion
5073848RH137673215192921749829217713Ratregion
5076596RH139267128193051196130512089Ratregion
5075618RH138698145192795235127952496Ratregion
5079548RH141061220192911315529113375Ratregion
5079592RH141089215193029567630295891Ratregion
5077852RH139997184192876547828765662Ratregion
5079770RH141193182192745055827450740Ratregion
5070946RH134797187192703694027037127Ratregion
5071064RH134865217192724992227250139Ratregion
5071482RH135107200192716168027161880Ratregion
5070714RH134662186192484232724842513Ratregion
5073886RH137695183192502786925028052Ratregion
5073188RH137291183192956333429563517Ratregion
5071240RH134968208192953183929532047Ratregion
5067676AU047602235192936232229362552Ratregion
5069744AU029195144192616130326161447Ratregion
5069256AU046616277192725993427260150Ratregion
5065174BE121076187192865674528656932Ratregion
5064118BE120629155193038017030380325Ratregion
5064072BI296164151193048923330489384Ratregion
5062748AW534219206192933479729335003Ratregion
5086939AA800507170193044679230446962Ratregion
5087350BQ193997161193071370030713861Ratregion
5082851BF3902630192716530927165462Ratregion
5087836Eif2a309192541265925412966Ratregion
5080768RH141770185192789037327890558Ratregion
5506068UniSTS:4982971521192821650528218026Ratregion
5506427UniSTS:479241540192941071229411252Ratregion
5507027fk81g07.x1974192516846525169439Ratregion
5500456AA55556448192715710627157155Ratregion
5499979UniSTS:235942241192716396027164201Ratregion
5499983UniSTS:235937211192911245329112664Ratregion
5499975UniSTS:235940201192823601928236220Ratregion
5500829STS-Z407031034192765877827659812Ratregion
5501301STS-F04943547192587864925879196Ratregion
5501456Ucp1196192481577424816631Ratregion
5501251PMC166143P297192982035729820454Ratregion
5501546WI-11812143192981938629819529Ratregion
Position Markers

Flank 1: (D19Mit9)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21924,816,041 - 24,816,202 (-)MAPPER
Rnor_6.01924,457,627 - 24,457,787NCBI
Rnor_5.01935,435,631 - 35,435,791UniSTS
RGSC_v3.41926,534,810 - 26,534,971RGD
RGSC_v3.41926,534,809 - 26,534,971UniSTS
RGSC_v3.11926,539,634 - 26,539,797RGD
Celera1924,355,706 - 24,355,866UniSTS
Cytogenetic Map19p11-q11UniSTS
Flank 2: (D19Mit5)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21933,061,792 - 33,061,905 (+)MAPPER
Rnor_6.01937,140,123 - 37,140,233NCBI
Rnor_5.01948,006,288 - 48,006,398UniSTS
RGSC_v3.41934,998,494 - 34,998,604RGD
RGSC_v3.41934,998,494 - 34,998,604UniSTS
RGSC_v3.11935,003,375 - 35,003,485RGD
Celera1932,490,973 - 32,491,083UniSTS
Cytogenetic Map19q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Eae8

RGD Curation Notes
Note Type Note Reference