GWAS1126805_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL: GWAS1126805_H (tobacco smoke exposure measurement QTL GWAS1126805 (human)) Homo sapiens

Symbol: GWAS1126805_H
Name: tobacco smoke exposure measurement QTL GWAS1126805 (human)
RGD ID: 597030731
Trait: tobacco smoke exposure measurement
LOD Score: Not Available
P Value: 6E-118
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381578,513,681 - 78,513,682RGD_MAPPER_PIPELINEGRCh38
GRCh371578,806,023 - 78,806,024RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1126805_HHumantobacco smoke exposure measurement  IAGPrs8034191405850206 GWAS_CATALOGPMID:30679032
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1606741HYKKhydroxylysine kinase157850757778537373Human

Position Markers

Peak: (rs8034191)
Human AssemblyChrPosition (strand)Source
GRCh381578,513,681 - 78,513,682RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597020468GWAS1116542_HFEV/FVC ratio QTL GWAS1116542 (human)2e-10FEV/FVC ratioforced expiratory volume to forced vital capacity ratio (CMO:0000241)157851368178513682Human
597218105GWAS1314179_Hnicotine dependence QTL GWAS1314179 (human)1e-70nicotine dependence157851368178513682Human
597020817GWAS1116891_HFEV/FVC ratio, response to bronchodilator QTL GWAS1116891 (human)0.0000003FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)157851368178513682Human
407021124GWAS670100_Hchronic obstructive pulmonary disease QTL GWAS670100 (human)1e-10lung integrity trait (VT:0010906)157851368178513682Human
407160725GWAS809701_HFEV/FVC ratio, response to bronchodilator QTL GWAS809701 (human)6e-14FEV/FVC ratio, response to bronchodilatorforced expiratory volume to forced vital capacity ratio (CMO:0000241)157851368178513682Human
597129158GWAS1225232_Hcigarettes per day measurement QTL GWAS1225232 (human)0.0000006cigarettes per day measurement157851368178513682Human
597204491GWAS1300565_Hbrain aneurysm QTL GWAS1300565 (human)3e-08brain aneurysm157851368178513682Human
407019734GWAS668710_Hlung carcinoma QTL GWAS668710 (human)3e-26lung carcinoma157851368178513682Human
406964980GWAS613956_Hforced expiratory volume, response to bronchodilator QTL GWAS613956 (human)1e-13forced expiratory volume, response to bronchodilatorforced expiratory volume (CMO:0000254)157851368178513682Human
597030720GWAS1126794_Hcigarettes per day measurement QTL GWAS1126794 (human)1e-139cigarettes per day measurement157851368178513682Human
407041428GWAS690404_Hlung carcinoma QTL GWAS690404 (human)1e-08lung carcinoma157851368178513682Human
407020282GWAS669258_Hlung carcinoma QTL GWAS669258 (human)5e-20lung carcinoma157851368178513682Human
407020287GWAS669263_Hlung carcinoma QTL GWAS669263 (human)3e-18lung carcinoma157851368178513682Human
597030731GWAS1126805_Htobacco smoke exposure measurement QTL GWAS1126805 (human)6e-118tobacco smoke exposure measurement157851368178513682Human
597020458GWAS1116532_Hforced expiratory volume QTL GWAS1116532 (human)3e-09forced expiratory volumeforced expiratory volume (CMO:0000254)157851368178513682Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS1116532_H GCST003266 Pre bronchodilator FEV1 6,659 European ancestry current and former smoker individuals ? NR 3E-9 8.523 rs8034191 0.07893 forced expiratory volume (EFO:0004314)
PMID:26634245
GWAS1116542_H GCST003267 Pre bronchodilator FEV1/FVC ratio 6,659 European ancestry current and former smoker individuals ? NR 2E-10 9.699 rs8034191 0.01688 FEV/FVC ratio (EFO:0004713)
PMID:26634245
GWAS1116891_H GCST003265 Post bronchodilator FEV1/FVC ratio in COPD 5,439 European ancestry current and former smoker cases, 821 African American current and former smoker cases T 0.403 3E-7 6.523 rs8034191 0.013 FEV/FVC ratio (EFO:0004713)
response to bronchodilator (GO:0097366)
PMID:26634245
GWAS1126794_H GCST008809 Smoking behaviour (cigarettes smoked per day) up to 153,918 European ancestry individuals C 0.341 1E-139 139 rs8034191 0.0956 cigarettes per day measurement (EFO:0006525)
PMID:30679032
GWAS1126805_H GCST008803 Smoking behaviour (cigarette pack-years) up to 150,993 European ancestry individuals C 0.338 6E-118 117.222 rs8034191 0.0819 tobacco smoke exposure measurement (EFO:0009115)
PMID:30679032
GWAS613956_H GCST003262 Post bronchodilator FEV1 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals T 0.335 1E-13 13 rs8034191 0.07 forced expiratory volume (EFO:0004314)
response to bronchodilator (GO:0097366)
PMID:26634245
GWAS668710_H GCST000459 Lung cancer 1,952 European ancestry cases, 1,438 European ancestry controls ? NR 3E-26 25.523 rs8034191 1.29 lung carcinoma (EFO:0001071)
PMID:19654303
GWAS669258_H GCST000170 Lung cancer 1,926 European ance other ancestry cases, 2,522 European and other ancestry controls C 0.34 5E-20 19.302 rs8034191 1.3 lung carcinoma (EFO:0001071)
PMID:18385738
GWAS669263_H GCST000172 Lung cancer 1,154 European ancestry cases, 1,137 European ancestry controls G NR 3E-18 17.523 rs8034191 1.3 lung carcinoma (EFO:0001071)
PMID:18385676
GWAS670100_H GCST000359 Chronic obstructive pulmonary disease 823 cases, 810 controls C 0.33 1E-10 10 rs8034191 1.4 chronic obstructive pulmonary disease (EFO:0000341)
PMID:19300482
GWAS690404_H GCST000233 Lung cancer 194 European ancestry cases, 219 European ancestry controls G NR 1E-8 8 rs8034191 1.38 lung carcinoma (EFO:0001071)
PMID:18780872
GWAS1225232_H GCST012716 ICD10 Z72.0: Tobacco use 7,432 individuals ? NR 6E-7 6.222 rs8034191 N/A cigarettes per day measurement (EFO:0006525)
PMID:29758381
GWAS809701_H GCST003264 Post bronchodilator FEV1/FVC ratio 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals T 0.331 6E-14 13.222 rs8034191 0.014 FEV/FVC ratio (EFO:0004713)
response to bronchodilator (GO:0097366)
PMID:26634245
GWAS1300565_H GCST011021 Intracranial aneurysm 7,495 European ancestry cases, 3,259 East Asian ancestry cases, 71,934 European ancestry controls, 234,948 East Asian ancestry controls T 0.676 3E-8 7.523 rs8034191 0.117 brain aneurysm (EFO:0003870)
PMID:33199917
GWAS1314179_H GCST011754 Nicotine dependence 46,213 European ancestry individuals, 11,787 African American individuals T NR 1E-70 70 rs8034191 0.06 nicotine dependence (EFO:0003768)
PMID:33144568
Database Acc Id Source(s)
GWAS Catalog GCST008803 GWAS Catalog

RGD Curation Notes
Note Type Note Reference