Bss99 QTL Report (Rattus norvegicus)

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QTL Registration

General

QTL: Bss99 (Bone structure and strength QTL 99) Rattus norvegicus
Symbol:	Bss99
Name:	Bone structure and strength QTL 99
RGD ID:	5684963
Trait:	tibia area (VT:1000281)
Measurement Type:	tibia area measurement (CMO:0001382)
LOD Score:	3.1
P Value:	Not Available
Variance:	Not Available
Position	No map positions available.
Cross Type:	Not Available
Strains Crossed:	GK/KyoSwe F344/DuCrlSwe

Annotation Click to see Annotation Detail View

Experimental Data Annotations Click to see Annotation Detail View

Clinical Measurement

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
tibia area measurement		IDA		5684953		RGD

Experimental Condition

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
control condition		IDA		5684953		RGD

Measurement Method

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
dual-energy x-ray absorptiometry		IDA		5684953		RGD

Rat Strain

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
F344/DuCrlSwe		IEA		5684953		RGD
GK/KyoSwe		IEA		5684953		RGD

Vertebrate Trait

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
tibia area		IDA		5684953		RGD

Disease Annotations Click to see Annotation Detail View

osteopetrosis (IAGP)

Experimental Data Annotations Click to see Annotation Detail View

Clinical Measurement

tibia area measurement (IDA)

Experimental Condition

control condition (IDA)

Measurement Method

dual-energy x-ray absorptiometry (IDA)

Vertebrate Trait

tibia area (IDA)

Rat Strain

F344/DuCrlSwe (IEA)

GK/KyoSwe (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of candidate gene regions in the rat by co-localization of QTLs for bone density, size, structure and strength.	Lagerholm S, etal., PLoS One. 2011;6(7):e22462. Epub 2011 Jul 27.

Region

Markers in Region

The following Markers overlap with this region.

RGD ID

Symbol

Expected Size

Chr

Start

Stop

Species

Match

Position Markers

Flank 1: (D6Mgh11)

Rat Assembly	Chr	Position (strand)	Source
RH 3.4 Map	6	288.5	UniSTS
RH 3.4 Map	6	288.5	RGD
RH 2.0 Map	6	454.4	RGD
Cytogenetic Map	6		RGD

Flank 2: (D3Mit19)

Rat Assembly	Chr	Position (strand)	Source
RGSC_v3.1	6	98,838,518 - 98,838,852	RGD

Additional Information

RGD Curation Notes

Note Type	Note	Reference
qtl_general	number of animals used: 19 parental GK, 20 parental F344, 37 F₁ and 206 F₂ rats	5684953
qtl_general	lineage: F₁ animals from both the reciprocal crosses were used; 2 seperate F₂ intercrosses were generated, one from grandmaternal GK and grandpaternal F344, the other from grandmaternal F344 and grandpaternal GK	5684953
qtl_general	measurement method: at 215 days (mean age) rats kept under controlled conditions were sacrificed and left tibia was subjected to two-dimensional dual energy X-ray absorptiometry using a PIXImus^TM densitometer (GE Lunar, Madison, WI)	5684953
qtl_general	software used: user-defined region of bone area measured using GE Lunar software	5684953
qtl_general	this region (30-60 cM) is determined in grand-maternal F344 and grand-paternal GK F₂ male rats	5684953

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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QTL: Bss99 (Bone structure and strength QTL 99) Rattus norvegicus