Mcs27 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Mcs27 (Mammary carcinoma susceptibility QTL 27) Rattus norvegicus

Symbol: Mcs27
Name: Mammary carcinoma susceptibility QTL 27
RGD ID: 4145117
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: post-insult time to mammary tumor formation   (CMO:0000345)    
LOD Score: Not Available
P Value: 1.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81345,990,077 - 50,392,939RGD_MAPPER_PIPELINE
mRatBN7.21343,437,904 - 47,841,255RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01348,776,655 - 53,264,877RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01353,846,466 - 58,314,767RGDRnor5.0
RGSC_v3.41344,872,181 - 49,428,577RGDRGSC3.4
Cross Type: intercross
Strains Crossed: SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi 
JBrowse: View Region in Genome Browser (JBrowse)



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique. Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45.
Related QTLs

Related QTL Description Reference
Mcs26 maps to same region RGD:4143380


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
402020844LOC134481494uncharacterized LOC134481494134598778146003464Rat
1310504Elk4ETS transcription factor ELK4134600414546027206Rat
1566090Mfsd4amajor facilitator superfamily domain containing 4A134601532146062633Rat
402153142LOC134481495uncharacterized LOC134481495134610620946108031Rat
1309523Cdk18cyclin-dependent kinase 18134610776346140705Rat
2322707Lemd1LEM domain containing 1134618386046250105Rat
402419174Blacat1BLACAT1 overlapping LEMD1 locus134618909146202506Rat
2325610Mir135bmicroRNA 135b134619101846191114Rat
1305132Klhdc8akelch domain containing 8A134628701146296429Rat
1359167Nuak2NUAK family kinase 2134630574446322755Rat
41351842LOC120096185uncharacterized LOC120096185134630664446312571Rat
1311960Tmcc2transmembrane and coiled-coil domain family 2134634617746383862Rat
735051Dstykdual serine/threonine and tyrosine protein kinase134640941246457426Rat
1305532Rbbp5RB binding protein 5, histone lysine methyltransferase complex subunit134646438946494244Rat
1561544Tmem81transmembrane protein 81134649180846494239Rat
3821Cntn2contactin 2134649726946528112Rat
41226902LOC120096452U6 spliceosomal RNA134651669246516798Rat
620911Nfascneurofascin134654936946735989Rat
2322511Tmem126a-ps2transmembrane protein 126A, pseudogene 2134675193346752559Rat
41077524LOC120096186uncharacterized LOC120096186134675706646761824Rat
11377184LOC108352532uncharacterized LOC108352532134677269546774230Rat
40993431LOC120096406small nucleolar RNA SNORA17134680686946806990Rat
1305482Lrrn2leucine rich repeat neuronal 2134687404846934544Rat
1309306Mdm4MDM4 regulator of p53134692223647068241Rat
41401176Trnak-uuu7transfer RNA lysine (anticodon UUU) 7134703399447034066Rat
41278710Trnak-uuu8transfer RNA lysine (anticodon UUU) 8134703438547034457Rat
1306541Pik3c2bphosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta134704686647107733Rat
1307944Ppp1r15bprotein phosphatase 1, regulatory subunit 15B134713000047137805Rat
1564395Plekha6pleckstrin homology domain containing A6134716689947307003Rat
1566310Golt1agolgi transport 1A134731241247325176Rat
727850Kiss1KiSS-1 metastasis-suppressor134732715947332759Rat
3554Renrenin134734831247359539Rat
7501983LOC102550525uncharacterized LOC102550525134735161547354626Rat
1305304Etnk2ethanolamine kinase 2134736296447381100Rat
1309674Sox13SRY-box transcription factor 13134738314547427572Rat
9461626LOC103692077uncharacterized LOC103692077134748004047489631Rat
2321675Snrpesmall nuclear ribonucleoprotein polypeptide E134759632447609390Rat
402082010LOC134481497uncharacterized LOC134481497134760932147619108Rat
1308290Zc3h11azinc finger CCCH-type containing 11A134762544447665971Rat
9238526Zbed6zinc finger, BED-type containing 6134765926947665540Rat
11453213LOC108352533uncharacterized LOC108352533134766834047677110Rat
41075572Ndufb10-ps1NADH:ubiquinone oxidoreductase subunit B10, pseudogene 1134767325247674130Rat
1563522Lax1lymphocyte transmembrane adaptor 1134768684047697396Rat
41337984LOC120096250uncharacterized LOC120096250134768834147692269Rat
621305Atp2b4ATPase plasma membrane Ca2+ transporting 4134770815747807389Rat
402308424LOC134481499uncharacterized LOC134481499134775917347763741Rat
402278584LOC134481498uncharacterized LOC134481498134778546947788396Rat
1304916Optcopticin134790614547920334Rat
620226Prelpproline and arginine rich end leucine rich repeat protein134792048047943547Rat
7514622LOC102557118uncharacterized LOC102557118134793249647940039Rat
401996399LOC134481559uncharacterized LOC134481559134797957647995599Rat
402062390LOC134481558uncharacterized LOC134481558134799062148006087Rat
619769Fmodfibromodulin134804556748056184Rat
41104579LOC120096251uncharacterized LOC120096251134805512248075144Rat
2225Btg2BTG anti-proliferation factor 2134808393148087690Rat
1305646Chit1chitinase 1134811788648165645Rat
7633688LOC102552406uncharacterized LOC102552406134818006048193754Rat
620874Chi3l1chitinase 3 like 1134819383948201822Rat
620287Mybphmyosin binding protein H134820516248212928Rat
2048Adora1adenosine A1 receptor134821092248247826Rat
620432Myogmyogenin134829747648300065Rat
620055Ppfia4PTPRF interacting protein alpha 4134830584448354329Rat
41016284LOC120096189uncharacterized LOC120096189134830811648311702Rat
1309892Tmem183atransmembrane protein 183A134835566448372437Rat
1359351Mgat4fMGAT4 family, member F134838945148394857Rat
41359476LOC120096190uncharacterized LOC120096190134839591748406868Rat
1306084Cyb5r1cytochrome b5 reductase 1134840106148407466Rat
1303151Adipor1adiponectin receptor 1134841143848431251Rat
9078385Lnc134long non-coding RNA 134134844696748451885Rat
628717Klhl12kelch-like family member 12134845192048485638Rat
1583292Ndufv3-ps1NADH:ubiquinone oxidoreductase subunit V3, pseudogene 1134846824348468676Rat
402424137LOC134481560uncharacterized LOC134481560134848662648488170Rat
1359331RabifRAB interacting factor134848837048500853Rat
1592636Rps7-ps10ribosomal protein S7, pseudogene 10134850265048506327Rat
1308112Mgat4eMGAT4 family member E134853479248555956Rat
1565602Kdm5blysine demethylase 5B134855436748625721Rat
3804Syt2synaptotagmin 2134863963448749814Rat
1309287Ppp1r12bprotein phosphatase 1, regulatory subunit 12B134875125648948933Rat
41052885Ube2c-ps4ubiquitin-conjugating enzyme E2C, pseudogene 4134878990548797797Rat
1310816Ube2tubiquitin-conjugating enzyme E2T134895516648965668Rat
1560339Lgr6leucine-rich repeat-containing G protein-coupled receptor 6134897619349095870Rat
621123Ptprvprotein tyrosine phosphatase, receptor type, V134909992249120247Rat
708516Ptpn7protein tyrosine phosphatase, non-receptor type 7134912267949136096Rat
40989265LOC120096252uncharacterized LOC120096252134913267249134442Rat
1565940Arl8aARF like GTPase 8A134913763249146633Rat
628835Gpr37l1G protein-coupled receptor 37-like 1134915035549157204Rat
1310687Elf3E74 like ETS transcription factor 3134924226549247102Rat
621137Rnpeparginyl aminopeptidase134925125949271440Rat
3862Timm17atranslocase of inner mitochondrial membrane 17A134928291849296363Rat
1307236Lmod1leiomodin 1134930569349347970Rat
41130351LOC120096253uncharacterized LOC120096253134931479549328241Rat
1312041Shisa4shisa family member 4134935151849355599Rat
1310537Ipo9importin 9134936224449414477Rat
1590261Nav1neuron navigator 1134941875549671117Rat
402057982LOC134481562uncharacterized LOC134481562134951789949532217Rat
41245870LOC120096254uncharacterized LOC120096254134963722149649141Rat
7528970LOC102553722uncharacterized LOC102553722134966925549678226Rat
62053Csrp1cysteine and glycine-rich protein 1134970992849731141Rat
1310502Phlda3pleckstrin homology-like domain, family A, member 3134974500349748088Rat
1589074Rpl11-ps12ribosomal protein L11, pseudogene 12134974575849759291Rat
402030467LOC134481563uncharacterized LOC134481563134976444449766047Rat
621765Tnni1troponin I1, slow skeletal type134978152949793385Rat
1310652Lad1ladinin 1134980134749815709Rat
3882Tnnt2troponin T2, cardiac type134981912349837125Rat
1307472Pkp1plakophilin 1134986134049909162Rat
1565384Igfn1immunoglobulin-like and fibronectin type III domain containing 1134994733049979203Rat
1307922Tmem9transmembrane protein 9135000882950027556Rat
1561854Ascl5achaete-scute family bHLH transcription factor 5135004352050044988Rat
70983Cacna1scalcium voltage-gated channel subunit alpha1 S135004566850115903Rat
402116829LOC134481564uncharacterized LOC134481564135011287650127701Rat
1306206Kif21bkinesin family member 21B135012784250177822Rat
1562634Mroh3maestro heat-like repeat family member 3135018171350217164Rat
9333559Mrpl42l1mitochondrial ribosomal protein L42 like 1135019571050196366Rat
1311892Inavainnate immunity activator135021814950238430Rat
41177193LOC120096257uncharacterized LOC120096257135022072850229229Rat
41070118LOC120096220uncharacterized LOC120096220135023828450242169Rat
1311611Gpr25G protein-coupled receptor 25135026451650266422Rat
1310950Camsap2calmodulin regulated spectrin-associated protein family, member 2135027495050354298Rat
402112328LOC134481565uncharacterized LOC134481565135032140050332540Rat
402092561LOC134481561uncharacterized LOC134481561134852151948543102Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
11231D13Wox5186134735425847354444Ratregion
11232D13Arb7315134735414347354458Ratregion
11375D13Arb8195134874471148744906Ratregion
11433D13Mgh15525134983443449834959Ratregion
37314D13Rat101180135039275950392939Ratregion
36884D13Rat25175134760142647601601Ratregion
35925D13Rat41161134627292246273083Ratregion
38020D13Rat87169134618969146189860Ratregion
38240D13Rat91188134796980547969993Ratregion
40688D13Rat124232134778041847780650Ratregion
41146D13Rat125247134804987148050118Ratregion
41346D13Rat123134134599007745990211Ratregion
42992D13Rat176209134908250849082717Ratregion
40948D13Rat120145134676325746763402Ratregion
45047D13Got25133134643768246437815Ratregion
45048D13Wox2141134771432647714467Ratregion
45052D13Got26184134782452847824712Ratregion
45053D13Got30241134868390148684142Ratregion
60037D13Got28159134791490047915059Ratregion
60042D13Got37249135033020250330451Ratregion
66668D13Mco10219134829096248291181Ratregion
8694274D13Hmgc4751193134794374547943938Ratregion
8694276D13Hmgc990198134807655548076753Ratregion
8694278D13Hmgc3694197134808616548086362Ratregion
8694280D13Hmgc325189134808813848088327Ratregion
5037217RH127096242134830752648307768Ratregion
5028699RH7104078135007908750079165Ratregion
5026150RH131106731134983622949836960Ratregion
5029377RH144564155134770849347708648Ratregion
5030403BE112734175134913492049135095Ratregion
5051623BB176431100134821394948214049Ratregion
5051791RH94660136134973039249730528Ratregion
5055845RH144035136134927978749279923Ratregion
5053003RH142398279134629224746292526Ratregion
5040728RH128449695134821209048212785Ratregion
5067316AU047830220135014993750150157Ratregion
5070161RH94507190134734794447348134Ratregion
5081491AA998833157134732500447325161Ratregion
5080850RH141819190134675898046759170Ratregion
5500063UniSTS:236515199134648978346489982Ratregion
5502819TNNI1990134979107449792064Ratregion
12832756rs1069358350134808875548088755Ratregion
128592802340203134819395248194155Ratregion
12859027rs1981993230134806864548068645Ratregion
Position Markers

Flank 1: (D13Rat123)
Rat AssemblyChrPosition (strand)Source
GRCr81345,990,077 - 45,990,211 (+)Marker Load Pipeline
mRatBN7.21343,437,904 - 43,438,038 (+)MAPPER
Rnor_6.01348,776,655 - 48,776,788NCBI
Rnor_5.01353,846,466 - 53,846,599UniSTS
RGSC_v3.41344,872,181 - 44,872,315RGD
RGSC_v3.41344,872,182 - 44,872,315UniSTS
Celera1343,774,561 - 43,774,698UniSTS
RGSC_v3.11344,886,225 - 44,886,358RGD
RH 3.4 Map13112.8RGD
RH 3.4 Map13112.8UniSTS
RH 2.0 Map13330.6RGD
SHRSP x BN Map1311.3299RGD
Flank 2: (D13Rat101)
Rat AssemblyChrPosition (strand)Source
GRCr81350,392,759 - 50,392,939 (+)Marker Load Pipeline
mRatBN7.21347,841,075 - 47,841,255 (+)MAPPER
Rnor_6.01353,264,698 - 53,264,877NCBI
Rnor_5.01358,314,588 - 58,314,767UniSTS
RGSC_v3.41349,428,398 - 49,428,577UniSTS
RGSC_v3.41349,428,397 - 49,428,577RGD
Celera1348,152,996 - 48,153,175UniSTS
RGSC_v3.11349,442,478 - 49,442,657RGD
RH 3.4 Map13148.8RGD
RH 3.4 Map13148.8UniSTS
FHH x ACI Map1319.33UniSTS
FHH x ACI Map1319.33RGD


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134627292251216694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134760142648068645Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134373632747969993Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134599007750392939Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134778041850392939Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general animals used: 47-57 days old virgin females 4143380
qtl_general inducing agent: DMBA (65 mg/kg of body wt) 4143380
qtl_map spans 4.5 Mbp and has 85 genes out of which 8% genes per Kbp are breast-cancer related 4143380