GWAS728223_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS728223_H (collagenous colitis QTL GWAS728223 (human)) Homo sapiens

Symbol: GWAS728223_H
Name: collagenous colitis QTL GWAS728223 (human)
RGD ID: 407079247
Trait: collagenous colitis
LOD Score: Not Available
P Value: 2.0E-11
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38632,638,107 - 32,638,108RGD_MAPPER_PIPELINEGRCh38
GRCh37632,605,884 - 32,605,885RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Colitis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
151675939HLA-DQA1-AS1HLA-DQA1 antisense RNA 163263499132641310Human
1351810HLA-DQA1major histocompatibility complex, class II, DQ alpha 163263740632655272Human

Position Markers

Peak: (rs2187668)
Human AssemblyChrPosition (strand)Source
GRCh38632,638,107 - 32,638,108RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407080899GWAS729875_Hsystemic lupus erythematosus QTL GWAS729875 (human)1e-09systemic lupus erythematosus63263810732638108Human
407081187GWAS730163_Hinflammatory bowel disease QTL GWAS730163 (human)0.0000002inflammatory bowel disease63263810732638108Human
407079233GWAS728209_Hcutaneous lupus erythematosus QTL GWAS728209 (human)4e-10cutaneous lupus erythematosus63263810732638108Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
407012420GWAS661396_Hsystemic lupus erythematosus QTL GWAS661396 (human)3e-21systemic lupus erythematosus63263810732638108Human
1643377BW325_HBody weight QTL 325 (human)2.320.0005Body fat amount6691196032911960Human
1643569GLUCO21_HGlucose level QTL 21 (human)0.021Glucose levelnon-insulin-dependent6691196032911960Human
1298458BW9_HBody weight QTL 9 (human)2.70.0002Body fat amount6691196032911960Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
407010222GWAS659198_Hceliac disease QTL GWAS659198 (human)1e-50celiac disease63263810732638108Human
407079247GWAS728223_Hcollagenous colitis QTL GWAS728223 (human)2e-11collagenous colitis63263810732638108Human
407008751GWAS657727_Hceliac disease QTL GWAS657727 (human)1e-19celiac disease63263810732638108Human
407004045GWAS653021_Hprotein measurement QTL GWAS653021 (human)2e-33protein measurement63263810732638108Human
406965681GWAS614657_HAutoimmune Hepatitis QTL GWAS614657 (human)2e-78Autoimmune Hepatitis63263810732638108Human
407079251GWAS728227_Hdiastolic blood pressure QTL GWAS728227 (human)4e-11diastolic blood pressurediastolic blood pressure (CMO:0000005)63263810732638108Human
407003699GWAS652675_Hmembranous glomerulonephritis QTL GWAS652675 (human)8e-93membranous glomerulonephritis63263810732638108Human
1358854MULTSCL4_HMultiple sclerosis susceptibility QTL 4 (human)Multiple sclerosis susceptibility6691196032911960Human
407080919GWAS729895_Hulcerative colitis QTL GWAS729895 (human)0.000004ulcerative colitis63263810732638108Human
406970201GWAS619177_Hdiastolic blood pressure QTL GWAS619177 (human)0.000008diastolic blood pressurediastolic blood pressure (CMO:0000005)63263810732638108Human
406978041GWAS627017_Hsarcoidosis QTL GWAS627017 (human)5e-36sarcoidosis63263810732638108Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human
1643399BMD5_HBone mineral density QTL 5 (human)2.320.0005Bone mineral density6691196032911960Human
407008220GWAS657196_Hsystemic lupus erythematosus QTL GWAS657196 (human)6e-28systemic lupus erythematosus63263810732638108Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS614657_H GCST002423 Autoimmune hepatitis type-1 649 European ancestry cases, 13,436 European ancestry controls ? 0.15 2E-78 77.699 rs2187668 2.9 Autoimmune Hepatitis (EFO:0005676)
 PMID:24768677
GWAS619177_H GCST006020 Diastolic blood pressure up to 165,276 European ancestry individuals, up to 27,487 South Asian ancestry individuals T 0.1281 0.000008 5.097 rs2187668 0.0258 diastolic blood pressure (EFO:0006336)
 PMID:27618447
GWAS627017_H GCST005541 Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) 664 Swedish ancestry non-Lofgren's syndrome cases, 384 Swedish ancestry Lofgren's syndrome cases A 0.359 5E-36 35.302 rs2187668 3.4 PMID:26651848
GWAS652675_H GCST000984 Idiopathic membranous nephropathy 556 European ancestry cases, 2,338 European ancestry controls A 0.1297 8E-93 92.097 rs2187668 4.32 membranous glomerulonephritis (EFO:0004254)
 PMID:21323541
GWAS653021_H GCST000763 Immunoglobulin A 430 European ancestry cases, 1,090 European ancestry controls A 0.13 2E-33 32.699 rs2187668 2.53 protein measurement (EFO:0004747)
 PMID:20694011
GWAS657196_H GCST000996 Systemic lupus erythematosus 811 anti-dsDNA positive European ancestry cases, 906 anti-dsDNA negative European ancestry cases, 4,813 European ancestry controls A 0.12 6E-28 27.222 rs2187668 2.23 PMID:21408207
GWAS657727_H GCST000048 Celiac disease 778 European ancestry cases, 1,422 European ancestry controls A 0.14 1E-19 19 rs2187668 7.04 celiac disease (EFO:0001060)
 PMID:17558408
GWAS659198_H GCST000612 Celiac disease 4,533 European ancestry cases, 10,750 European ancestry controls A 0.26 1E-50 50 rs2187668 6.23 celiac disease (EFO:0001060)
 PMID:20190752
GWAS661396_H GCST000144 Systemic lupus erythematosus 1,311 European ancestry cases, 3,340 European ancestry controls A 0.11 3E-21 20.523 rs2187668 N/A PMID:18204098
GWAS728209_H GCST002884 Cutaneous lupus erythematosus 151 European ancestry cases, 1,288 European ancestry controls T 0.107 4E-10 9.398 rs2187668 2.93 cutaneous lupus erythematosus (EFO:0003834)
 PMID:25827949
GWAS728223_H GCST005879 Collagenous colitis 247 European ancestry cases, 3969 European ancestry controls ? 0.126 2E-11 10.699 rs2187668 2.06 collagenous colitis (EFO:1001293)
 PMID:26525574
GWAS728227_H GCST006258 Diastolic blood pressure up to 201,529 European ancestry individuals T 0.126 4E-11 10.398 rs2187668 0.372 diastolic blood pressure (EFO:0006336)
 PMID:27618452
GWAS729875_H GCST003103 Systemic lupus erythematosus 661 European ancestry cases, 487 European ancestry controls ? NR 1E-9 9 rs2187668 N/A PMID:26316170
GWAS729895_H GCST003960 Ulcerative colitis 269 Polish ancestry child cases, 259 Polish ancestry adult cases, 582 Polish ancestry controls ? NR 0.000004 5.398 rs2187668 2.21266 ulcerative colitis (EFO:0000729)
 PMID:28008999
GWAS730163_H GCST003958 Inflammatory bowel disease 622 Polish ancestry child cases, 496 Polish ancestry adult cases, 582 Polish ancestry controls ? NR 2E-7 6.699 rs2187668 1.9647566 inflammatory bowel disease (EFO:0003767)
 PMID:28008999
Database Acc Id Source(s)
GWAS Catalog GCST005879 GWAS Catalog

RGD Curation Notes
Note Type Note Reference