Anxrr23 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Anxrr23 (Anxiety related response QTL 23) Rattus norvegicus

Symbol: Anxrr23
Name: Anxiety related response QTL 23
RGD ID: 2306968
Trait: reflex trait   (VT:0001961)    
Measurement Type: amplitude of the acoustic startle response   (CMO:0001520)    
LOD Score: 4.83
P Value: Not Available
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81544,806,773 - 52,597,086RGD_MAPPER_PIPELINE
mRatBN7.21540,631,268 - 46,187,442RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01543,097,470 - 52,831,189RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.01548,493,430 - 56,554,042RGDRnor_5.0
RGSC_v3.41545,870,097 - 51,526,246RGDRGSC_v3.4
Cross Type: intercross
Strains Crossed: RLA/Verh RHA/Verh 



Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait
reflex trait  (IDA)

Rat Strain
RHA/Verh  (IEA)
RLA/Verh  (IEA)

References

References - curated
# Reference Title Reference Citation
1. A quantitative trait locus influencing anxiety in the laboratory rat. Fernandez-Teruel A, etal., Genome Res 2002 Apr;12(4):618-26.
2. Genetic control of the corticosterone level at rest and under emotional stress in ISIAH rats with inherited stress-induced arterial hypertension. Redina OE, etal., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502.
Related QTLs

Related QTL Description Reference
Srcrt8 maps to same region RGD:10053640


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2055Adra1aadrenoceptor alpha 1A154500564845111416Rat
2517Dpysl2dihydropyrimidinase-like 2154518104145287065Rat
1307266Pnma2PNMA family member 2154528744545296340Rat
621354Bnip3lBCL2 interacting protein 3 like154535008145373213Rat
620919Ppp2r2aprotein phosphatase 2, regulatory subunit B, alpha154538014245439428Rat
7527777LOC102555410uncharacterized LOC102555410154543948545455926Rat
402067108LOC134482137uncharacterized LOC134482137154544379445449246Rat
402454298LOC134481979large ribosomal subunit protein eL6-like154557032845574289Rat
1310805Ebf2EBF transcription factor 2154561094945809828Rat
402351354LOC134482138uncharacterized LOC134482138154575441545760868Rat
41152583LOC120097021uncharacterized LOC120097021154586664645872839Rat
41008930LOC120097231small nucleolar RNA SNORA17154596055345960683Rat
1566135Rpl36-ps13ribosomal protein L36, pseudogene154603577846036112Rat
1311003Cdca2cell division cycle associated 2154607136046117524Rat
1312010Kctd9potassium channel tetramerization domain containing 9154611721146145258Rat
2720Gnrh1gonadotropin releasing hormone 1154614787846152086Rat
9098115LOC103693653uncharacterized LOC103693653154614830946151894Rat
1306872Dock5dedicator of cytokinesis 5154615512446334127Rat
41400303Rps16-ps5ribosomal protein S16, pseudogene 5154645734846457799Rat
621458Neflneurofilament light chain154647733046481203Rat
2323627Slc25a3-ps1solute carrier family 25 member 3, pseudogene 1154652030246521674Rat
3160Nefmneurofilament medium chain154653585746541161Rat
402301986LOC134482139cilia- and flagella-associated protein 251-like154654100346559725Rat
2325104Brcc3-ps4BRCA1/BRCA2-containing complex, subunit 3, pseudogene 4154674805646749132Rat
40973991LOC120097024uncharacterized LOC120097024154678657546880347Rat
402253515LOC134481980uncharacterized LOC134481980154690881146921412Rat
62032Adam7ADAM metallopeptidase domain 7154700917647057581Rat
1309861Adamdec1ADAM-like, decysin 1154707601147097065Rat
7726377LOC102550654disintegrin and metalloproteinase domain-containing protein 28-like154711752947154293Rat
402059333LOC134478822disintegrin and metalloproteinase domain-containing protein 28-like154715516847172189Rat
7555795Ssxbl1SSX family member B like 1154718380347224423Rat
2323508Ube2v1l2ubiquitin conjugating enzyme E2 V1 like 2154730944147310019Rat
6493460Wdr82-ps4WD repeat domain 82, pseudogene 4154754143647542295Rat
1586394Wdr82-ps3WD repeat domain 82, pseudogene 3154758885847589955Rat
402087936LOC134481981uncharacterized LOC134481981155012777450134039Rat
1593232Rrs1-ps13ribosome biogenesis regulator 1 homolog, pseudogene 13155013671650138414Rat
1593231Septin2-ps1septin 2, pseudogene 1155017078950171897Rat
727820Adam28ADAM metallopeptidase domain 28155018428650250605Rat
7707332Rpl7a-ps3ribosomal protein L7a, pseudogene 3155048177550482571Rat
621776Stc1stanniocalcin 1155070943950720093Rat
1593230Rps17-ps4ribosomal protein S17, pseudogene 4155072917250729619Rat
402213545LOC134481982uncharacterized LOC134481982155075933550796810Rat
1306149Nkx2-6NK2 homeobox 6155085296550857060Rat
1305369Nkx3-1NK3 homeobox 1155088366150886253Rat
41166600LOC120097025uncharacterized LOC120097025155091590850921605Rat
1359361Slc25a37solute carrier family 25 member 37155094408550986506Rat
1566115Synbsyncytin b155098931350996237Rat
1590801Set-ps13Set nuclear proto-oncogene, pseudogene 13155101293451014616Rat
1309511Entpd4ectonucleoside triphosphate diphosphohydrolase 4155104066551068450Rat
1308435Loxl2lysyl oxidase-like 2155109154751182843Rat
1311790R3hcc1R3H domain and coiled-coil containing 1155118432851191640Rat
1308779Chmp7charged multivesicular body protein 7155120075951215992Rat
1308041Tnfrsf10bTNF receptor superfamily member 10b155124988351278091Rat
1309924Rhobtb2Rho-related BTB domain containing 2155127802451298209Rat
9259039LOC103693695uncharacterized LOC103693695155130159651309555Rat
7630497LOC102550955uncharacterized LOC102550955155131437451316727Rat
1593295Pebp4phosphatidylethanolamine binding protein 4155132812751543920Rat
2545Egr3early growth response 3155156048251565778Rat
1308253Bin3bridging integrator 3155158347451622329Rat
1309922Ccar2cell cycle and apoptosis regulator 2155162251951637911Rat
1308117C15h8orf58similar to human chromosome 8 open reading frame 58155163833651645141Rat
1359203Pdlim2PDZ and LIM domain 2155164719551659904Rat
402402112LOC134482142uncharacterized LOC134482142155165766151671756Rat
628900Sorbs3sorbin and SH3 domain containing 3155166263951699161Rat
621616Ppp3ccprotein phosphatase 3 catalytic subunit gamma155169958651771763Rat
402277934LOC134482141mitochondrial pyruvate carrier 1-like155173124551737692Rat
1307026Slc39a14solute carrier family 39 member 14155178651751833260Rat
1306964Piwil2piwi-like RNA-mediated gene silencing 2155184110451907729Rat
402393543LOC134482140histone deacetylase 1-like155185130851859221Rat
40950856LOC120097212small nucleolar RNA SNORA70155190110251901192Rat
41262530Trnap-agg23transfer RNA proline (anticodon AGG) 23155191203651912108Rat
1311816Polr3dRNA polymerase III subunit D155192128351925952Rat
2325539Mir320amicroRNA 320a155192608851926169Rat
41291261LOC120097030uncharacterized LOC120097030155194147551943703Rat
1305790Phyhipphytanoyl-CoA 2-hydroxylase interacting protein155194367051954921Rat
620739Bmp1bone morphogenetic protein 1155196131052005597Rat
402258362LOC134482143uncharacterized LOC134482143155199022151992474Rat
3666Sftpcsurfactant protein C155200627452009324Rat
1311079Lgi3leucine-rich repeat LGI family, member 3155201531752022445Rat
402426462LOC134482145uncharacterized LOC134482145155202783252029569Rat
1306561Reep4receptor accessory protein 4155203002252033229Rat
402444115HrurfHR upstream open reading frame155203646952039266Rat
620634HrHR, lysine demethylase and nuclear receptor corepressor155203654052056019Rat
1311802Nudt18nudix hydrolase 18155206029752062822Rat
1308870Fhip2bFHF complex subunit HOOK interacting protein 2B155206634152084296Rat
1311419Dmtndematin actin binding protein155208766752111956Rat
2607Fgf17fibroblast growth factor 17155211814152132083Rat
727816Npm2nucleophosmin/nucleoplasmin 2155213197352145710Rat
402283559LOC134482146uncharacterized LOC134482146155214568552148448Rat
1310928Xpo7exportin 7155215174352237729Rat
1310966Dok2docking protein 2155223704652251091Rat
61809Gfra2GDNF family receptor alpha 2155235149952443369Rat
41365565LOC12009699160S ribosomal protein L31-like155250364652510791Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10672D15Mgh1298154614700046147098Ratregion
11235D15Wox6221155244212152442342Ratregion
37954D15Rat61136155052455450524690Ratregion
34910D15Rat14144154480677344806917Ratregion
35611D15Rat11151155259693552597086Ratregion
38520D15Rat53139154660713046607269Ratregion
39490D15Rat112142155102766151027803Ratregion
42012D15Arb6241154614695646147197Ratregion
42405D15Rat164199154657750746577706Ratregion
45267D15Got46262154546169745461959Ratregion
60101D15Got53143155070912550709268Ratregion
1635969D15Got109168155202851652028684Ratregion
7206828Nfl190154648091646481106Ratregion
5027477AW04987095155195459851954693Ratregion
5051949RH94752170155200766452007834Ratregion
5051947RH94751126155200648952006615Ratregion
5058682BI284489178154518188545182063Ratregion
5049272RH133385197154511113345111330Ratregion
5079016RH140685192154535197145352163Ratregion
5080104RH141385164155156552451565688Ratregion
5066880AU048096171154684706446847235Ratregion
5067000AU048025254154513948945139743Ratregion
5067144AU047935219155211221152112430Ratregion
5503656Nefl974154648009646481070Ratregion
5501151PMC15073P3834154648005146480885Ratregion
Position Markers

Flank 1: (D15Rat14)
Rat AssemblyChrPosition (strand)Source
GRCr81544,806,773 - 44,806,917 (+)Marker Load Pipeline
mRatBN7.21540,631,268 - 40,631,412 (+)MAPPER
Rnor_6.01543,097,470 - 43,097,613NCBI
Rnor_5.01548,493,430 - 48,493,573UniSTS
RGSC_v3.41545,870,097 - 45,870,241RGD
RGSC_v3.41545,870,098 - 45,870,241UniSTS
Celera1540,303,246 - 40,303,389UniSTS
RGSC_v3.11545,885,878 - 45,886,021RGD
RH 3.4 Map15310.4UniSTS
RH 3.4 Map15310.4RGD
RH 2.0 Map15290.6RGD
SHRSP x BN Map1533.4699RGD
Peak: (D15Wox3)
Rat AssemblyChrPosition (strand)Source
GRCr81544,529,522 - 44,529,639 (+)Marker Load Pipeline
mRatBN7.21540,353,977 - 40,354,096 (+)MAPPER
Rnor_6.01542,820,558 - 42,820,674NCBI
Rnor_5.01548,773,415 - 48,773,531UniSTS
RGSC_v3.41545,582,469 - 45,582,586RGD
RGSC_v3.41545,582,470 - 45,582,586UniSTS
Celera1540,027,310 - 40,027,432UniSTS
RGSC_v3.11545,598,249 - 45,598,366RGD
RH 2.0 Map15296.8RGD
Cytogenetic Map15p12UniSTS
Flank 2: (D15Rat11)
Rat AssemblyChrPosition (strand)Source
GRCr81552,596,935 - 52,597,086 (+)Marker Load Pipeline
mRatBN7.21546,187,291 - 46,187,442 (+)MAPPER
Rnor_6.01552,831,039 - 52,831,189NCBI
Rnor_5.01556,553,892 - 56,554,042UniSTS
RGSC_v3.41551,526,095 - 51,526,246RGD
RGSC_v3.41551,526,096 - 51,526,246UniSTS
Celera1545,863,184 - 45,863,334UniSTS
RGSC_v3.11551,541,875 - 51,542,026RGD
SHRSP x BN Map1533.4699RGD
SHRSP x BN Map1533.4699UniSTS
FHH x ACI Map1546.36RGD


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154480677352597086Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154446544756583797Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general allele:RHA allele increases acoustic startle response and entries in the closed arm of the elevated plus maze 625384
qtl_general measurement method: rats were kept ina plexiglas sound-attenuated chamber lit by a bulb; after 5-min acclimatization, an acoustic stimuli of 110dB was given for 50 msec followed by startle-stimulus onset, mean startle response amplitude was calculated 625384
qtl_general software used:MAPMAKER-QTL 625384