Bp312 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Bp312 (Blood pressure QTL 312) Rattus norvegicus

Symbol: Bp312
Name: Blood pressure QTL 312
RGD ID: 2292440
Previously known as: C10QTL4; LVHC10QTL4
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: mean arterial blood pressure   (CMO:0000009)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,750,049 - 68,164,786RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01070,166,960 - 70,581,793RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01069,797,667 - 70,215,618RGDRnor5.0
RGSC_v3.41071,032,534 - 71,447,820RGDRGSC3.4
Cross Type: intercross
Strains Crossed: SS.LEW-(D10Chm246-D10Chm257)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Slfn4 is a candidate Gene for Bp312
Slfn2 is a candidate Gene for Bp312
Slfn14 is a candidate Gene for Bp312
Slfn3 is a candidate Gene for Bp312
Slfn1 is a candidate Gene for Bp312

Disease Annotations     Click to see Annotation Detail View
Hypotension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Unique quantitative trait loci in synergy permanently improve diastolic dysfunction. Chauvet C, etal., Can J Cardiol. 2013 Oct;29(10):1302-9. doi: 10.1016/j.cjca.2013.03.012. Epub 2013 Jun 14.
2. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
3. Submegabase resolution of epistatically interacting quantitative trait loci for blood pressure applicable for essential hypertension. Chauvet C, etal., J Hypertens. 2008 May;26(5):893-901.
Related QTLs

Related QTL Description Reference
Bp282 sub_region RGD:2292238
Bp310 interacts with RGD:7421500


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
71048Ap2b1adaptor related protein complex 2 subunit beta 1106809939768205023Rat
620757Pex12peroxisomal biogenesis factor 12106809577668103812Rat
620455Slfn4schlafen family member 4106799460168018141Rat
1308645Slfn2schlafen family member 2106795332267959659Rat
1310708Fndc8fibronectin type III domain containing 8106782595267834090Rat
1305666Unc45bunc-45 myosin chaperone B106784538267873389Rat
1308301Nle1notchless homolog 1106783405967844771Rat
1306944Rad51dRAD51 paralog D106780572067824452Rat
1359139Slfn13schlafen family member 13106790910567955912Rat
1312025Slfn5schlafen family member 5106788106867895013Rat
727916Rfflring finger and FYVE-like domain containing E3 ubiquitin protein ligase106774071167803694Rat
1583007Slfn1schlafen family member 1106795343067983287Rat
1564411Slfn3schlafen family member 3106802048268060248Rat
1561538Slfn14schlafen family member 14106807632668087794Rat
1582982LOC688925similar to Glutathione S-transferase alpha-4106800729768007919Rat
7614463LOC102556120schlafen family member 12-like106806463668068031Rat
7628561Gapdh-ps38Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 38106791199467914600Rat
11366402LOC108352183spindle and kinetochore-associated protein 2 pseudogene106793279067950325Rat
11414676LOC10835342540S ribosomal protein S27-like106808969468089966Rat
41116338LOC120095481U2 spliceosomal RNA106807250568072695Rat
41195735LOC120095352U6 spliceosomal RNA106782724167827353Rat
40983522Snord7small nucleolar RNA, C/D box 7106809501568095110Rat
40937372LOC120095157uncharacterized LOC120095157106807193568092771Rat
40964229Rpl5-ps9ribosomal protein L5, pseudogene 9106791364967914568Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36916D10Rat58170106778500967785171Ratregion
44760D10Got87161106776554667765709Ratregion
704348D10Wox51191106801182768012018Ratregion
1578826D10Chm192224106812744768127614Ratregion
1578826D10Chm192224106812744768127673Ratregion
1578834D10Chm255246106792999767930239Ratregion
1578838D10Chm177191106792613867926329Ratregion
1578870D10Chm176225106789207167892300Ratregion
1578875D10Chm187243106810989868110141Ratregion
1578886D10Chm146220106812884868129068Ratregion
1578904D10Chm133208106777683867777046Ratregion
1578911D10Chm178239106793957867939817Ratregion
1578927D10Chm189173106811683468117007Ratregion
1578930D10Chm191191106812704668127237Ratregion
1578931D10Chm171232106775004967750281Ratregion
1578948D10Chm132165106778071567780880Ratregion
1578953D10Chm188239106811334968113592Ratregion
1578956D10Chm181222106805904768059269Ratregion
1578956D10Chm181222106806484668065076Ratregion
1578963D10Chm145219106805904768059258Ratregion
1578963D10Chm145219106806484668065065Ratregion
1578985D10Chm175228106787089867871128Ratregion
1578994D10Chm147226106816456068164786Ratregion
1578998D10Chm251201106789209567892300Ratregion
1579016D10Chm190245106812381268124057Ratregion
1579020D10Chm257278106808367868083956Ratregion
1579050D10Chm174239106782778667828025Ratregion
1579056D10Chm244178106799729467997472Ratregion
1579072D10Chm121246106808236868082614Ratregion
1579075D10Chm144216106805904568059261Ratregion
1579075D10Chm144216106806484468065068Ratregion
1579077D10Chm179249106799336967993618Ratregion
1579083D10Chm246212106797932067979536Ratregion
1579104D10Chm252201106792613867926339Ratregion
1579140D10Chm256192106793965867939850Ratregion
1579148D10Chm183190106808367868083867Ratregion
1579161D10Chm173203106783075767830960Ratregion
1579169D10Chm172249106781590867816083Ratregion
1579180D10Chm245247106812709268127339Ratregion
1579188D10Chm180190106802303168023221Ratregion
1642085D10Mco86276106799337067993646Ratregion
1642089D10Mco87297106811338168113682Ratregion
5026532RH132572197106798308867983285Ratregion
5025172D11Pas17160106814547168145631Ratregion
5059350AI059154209106783416967834885Ratregion
5047190RH132185203106801787968018082Ratregion
5079620RH141107201106789433267894533Ratregion
5071058RH134862220106789451167894714Ratregion
5068738AU046963175106799346567993640Ratregion
5065448BI303082159106802752968027688Ratregion
5504165Unc45b511106786615867866669Ratregion
Position Markers

Flank 1: (D10Chm171)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21067,750,049 - 67,750,281 (+)MAPPER
Rnor_6.01070,166,960 - 70,167,191NCBI
Rnor_5.01069,797,667 - 69,797,898UniSTS
RGSC_v3.41071,032,534 - 71,032,765UniSTS
Celera1066,694,510 - 66,694,687UniSTS
Cytogenetic Map10q26UniSTS
Flank 2: (D10Chm147)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21068,164,560 - 68,164,786 (+)MAPPER
Rnor_6.01070,581,568 - 70,581,793NCBI
Rnor_5.01070,215,393 - 70,215,618UniSTS
RGSC_v3.41071,447,595 - 71,447,820UniSTS
Celera1067,107,082 - 67,107,307UniSTS
Cytogenetic Map10q26UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944767750281Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944767750281Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)106631944767750281Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944767750281Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944767750281Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944768164786Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944768164786Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944768164786Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944768164786Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)106697895567750281Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
1579917Bp282Blood pressure QTL 2820.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106740031668164786Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
2292440Bp312Blood pressure QTL 312arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106775004968164786Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general software package used: ANOVA 2292238
qtl_general number of animals used: 5 rats 2292238
qtl_general measurement method:male rats were weaned at 21 days, maintained on 0.2% NaCl diet; on day 35 they were fed a high-salt diet (2% NaCl); at day 56, telemetry probes were implanted 2292238
qtl_general directly exhibit a blood pressure effect 2292238
qtl_general harbors 5 genes from the Schlafen (Slfn) class 8657382