Pur16 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Pur16 (Proteinuria QTL 16) Rattus norvegicus

Symbol: Pur16
Name: Proteinuria QTL 16
RGD ID: 2292232
Trait: urine total protein amount   (VT:0000032)    
Measurement Type: urine protein level   (CMO:0000591)    
LOD Score: 17.2
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21336,155,723 - 41,961,389RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01341,060,057 - 47,227,923RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01346,171,139 - 52,282,100RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41337,191,203 - 43,437,366RGDRGSC3.4
Cross Type: backcross
Strains Crossed: BUF/Mna WKY/NCrlCrlj 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Actr3 is a candidate Gene for Pur16

Disease Annotations     Click to see Annotation Detail View
proteinuria  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait

Rat Strain
BUF/Mna  (IEA)
WKY/NCrlCrlj  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats. Akiyama K, et al., Mamm Genome. 2008 Jan;19(1):41-50. Epub 2007 Dec 7.
Related QTLs

Related QTL Description Reference
Pur1 sub_region RGD:2292230


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1306427Dpp10dipeptidyl peptidase like 10133458442036269619Rat
41288161LOC120096236uncharacterized LOC120096236133641760236440116Rat
7713048LOC102554127uncharacterized LOC102554127133646666736468943Rat
71024Actr3actin related protein 3133680073936843837Rat
7577736LOC102554198uncharacterized LOC102554198133684413936862825Rat
41047751LOC120096237uncharacterized LOC120096237133686292036867620Rat
2324561LOC100362110LRRGT00155-like133690776036941966Rat
1308125Slc35f5solute carrier family 35, member F5133699211837028549Rat
1306745Gpr39G protein-coupled receptor 39133711525837327312Rat
1549754Lypd1Ly6/Plaur domain containing 1133732645937368515Rat
1564507Nckap5NCK-associated protein 5133736994838283257Rat
1592076Psme2-ps1proteasome activator subunit 2, pseudogene 1133818937538190347Rat
40941817Ftl1-ps11ferritin light chain 1, pseudogene 11133849046838492427Rat
1563709tuba1c-ps1tubulin, alpha 1C, pseudogene 1133850748138508832Rat
41257974LOC120096238uncharacterized LOC120096238133857113338578302Rat
11417017LOC108352524cysteine and glycine-rich protein 2 pseudogene133858125138587400Rat
620100Mgat5alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase133867577638959697Rat
41024668LOC120096388small nucleolar RNA U6-53/MBII-28133885055138850659Rat
41170686LOC120096239uncharacterized LOC120096239133893059138934947Rat
1306212Tmem163transmembrane protein 163133896791339141664Rat
620868Acmsdaminocarboxymuconate semialdehyde decarboxylase133920048639244337Rat
11509631LOC108352526uncharacterized LOC108352526133924535439251593Rat
1309205Ccnt2cyclin T2133925157339293172Rat
1566400Map3k19mitogen-activated protein kinase kinase kinase 19133930015039343502Rat
1306487Rab3gap1RAB3 GTPase activating protein catalytic subunit 1133935569839429154Rat
41343085Fus-ps1FUS RNA binding protein, pseudogene 1133936160039366255Rat
41267176LOC120096387small nucleolar RNA SNORA36 family133936360339363733Rat
1564952Zranb3zinc finger RANBP2-type containing 3133944065339595782Rat
7489024Mir3473microRNA 3473133949924639499312Rat
41023674LOC120096241COX assembly mitochondrial protein homolog133951341939513580Rat
1307497R3hdm1R3H domain containing 1133959584839733876Rat
41386640Mea1-ps2male-enhanced antigen 1, pseudogene 2133961975939630738Rat
41108584LOC120096429U2 spliceosomal RNA133966495739665099Rat
2325574Mir128-1microRNA 128-1133969944939699530Rat
1307451Ubxn4UBX domain protein 4133974007739772347Rat
11453963LOC10835252760S ribosomal protein L37 pseudogene133974995339750218Rat
41380764Trnap-agg78transfer RNA proline (anticodon AGG) 78133976402339764103Rat
620823Lctlactase133978192939824456Rat
61967Mcm6minichromosome maintenance complex component 6133982674539851937Rat
41010028Trnas-aga41transfer RNA serine (anticodon AGA) 41133983277939832859Rat
621167Dars1aspartyl-tRNA synthetase 1133985793639913055Rat
2321949Rps26-ps11ribosomal protein S26, pseudogene 11133986368839864147Rat
1587045Ssbp1-ps2single stranded DNA binding protein 1, pseudogene 2133993478239936458Rat
41373884LOC120096378small nucleolar RNA SNORA70133998495139985085Rat
41049185LOC120096242uncharacterized LOC120096242134003193040047733Rat
620465Cxcr4C-X-C motif chemokine receptor 4134007797640081883Rat
7667252LOC102548838uncharacterized LOC102548838134016792440173369Rat
41259378LOC120096243uncharacterized LOC120096243134016797240168697Rat
7640179LOC102548908uncharacterized LOC102548908134033504140350489Rat
41017587LOC120096459U6 spliceosomal RNA134038967540389783Rat
11371098Gapdh-ps26Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 26134046535740466360Rat
2321906Gabarapl2-ps1GABA type A receptor associated protein like 2, pseudogene 1134066230740662660Rat
1306938Thsd7bthrombospondin type 1 domain containing 7B134076856741667262Rat
40965712LOC120096439U4 spliceosomal RNA134086368040863870Rat
41197309LOC120096244uncharacterized LOC120096244134119071441202717Rat
41212925LOC120096445U6 spliceosomal RNA134130467841304784Rat
2321708Mrpl30-ps2mitochondrial ribosomal protein L30, pseudogene 2134172398441724457Rat
620651Cd55CD55 molecule (Cromer blood group)134185724241885966Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
34351D13Mgh4150133741558437415726Ratregion
37022D13Rat149125133996684339967026Ratregion
37804D13Rat80245133801657138016830Ratregion
36695D13Rat38156133765865937658786Ratregion
36747D13Rat20138133726209237262232Ratregion
36767D13Rat40164133847804838478212Ratregion
34833D13Rat19169134196122441961389Ratregion
35130D13Rat22122134094979340949915Ratregion
40398D13Rat147258133913836339138623Ratregion
40744D13Rat122135134069764940697787Ratregion
38450D13Rat52244134078268540782928Ratregion
38530D13Rat94216133626080636261020Ratregion
39208D13Rat88233134118402241184251Ratregion
41978D13Arb5213133790260837902821Ratregion
41978D13Arb5213133790260837902821Ratregion
41222D13Rat114145133735094937351078Ratregion
41304D13Rat121125133849536238495491Ratregion
41366D13Rat119205133849016538490376Ratregion
42988D13Rat174235133869418038694475Ratregion
42989D13Rat199149133663126636631415Ratregion
40776D13Rat117212133653047236530684Ratregion
44552D9Wox21136133775293337752990Ratregion
43378D13Wox18310134007831040078623Ratregion
45025D13Got8111133615572336155834Ratregion
45026D13Got6180133738636237386542Ratregion
45028D13Got9249133790260637902855Ratregion
45028D13Got9249133790260637902855Ratregion
45029D13Got10145133787728237877427Ratregion
45030D13Got13234133836255238362788Ratregion
45031D13Got14163133862825438628419Ratregion
45033D13Got11238133890186238902100Ratregion
45034D13Got18180133894686238947042Ratregion
45036D13Got3290133643083936431129Ratregion
45037D13Got5252133647052336470772Ratregion
45038D13Got16245133996641539966660Ratregion
45039D13Got4169133714003737140206Ratregion
45040D13Got7149133689930736899456Ratregion
45045D13Got19209133996249839962707Ratregion
67818D13Uwm6236133797058337970825Ratregion
67818D13Uwm6236133797058337970825Ratregion
1582018D13Hmgc98183133950973339509916Ratregion
1582020D13Hmgc89207133636039436360601Ratregion
1582022D13Hmgc60124133795405037954174Ratregion
1582022D13Hmgc60124133795405037954174Ratregion
1582084D13Hmgc77211134067354140673752Ratregion
2324933D13Hmgc40258133874496838745230Ratregion
2324933D13Hmgc40258133874496838745230Ratregion
2324935D13Hmgc72195133758589237586087Ratregion
2324937D13Hmgc93173133740646737406640Ratregion
5036410UniSTS:143850231133962079239620946Ratregion
5037037AU050004114133755080637550920Ratregion
5029305RH144293171134076924740769418Ratregion
5032052AU046910135133699109036991227Ratregion
5032335AI853408118133732675837326876Ratregion
5034876AI013755111133942898439429095Ratregion
5033201RH137955147133732807337328220Ratregion
5025298RH127783203133973363339733836Ratregion
5028041MHAa78b9.seq168134124167141241839Ratregion
5030645BI301555173133685319036853363Ratregion
5033589RH13937996133867523738675333Ratregion
5059288BF387978180133888299038883170Ratregion
5045096RH130981180133929287239293052Ratregion
5045448RH131184185133896368438963869Ratregion
5045302RH131100190133924567739245867Ratregion
5047528RH132379161134185910141859262Ratregion
5039512RH127748186133977208939772275Ratregion
5041950RH129152214134007803340078248Ratregion
5039744RH127882187133929092539291112Ratregion
5074896RH138281120134016500940165129Ratregion
5076916RH139453120134186808141868201Ratregion
5075412RH138579188133974219639742384Ratregion
5079378RH140961192133928865439288846Ratregion
5076236RH139058120133896818838968308Ratregion
5079986RH141317207134186808141868288Ratregion
5073386RH137406197133976719239767389Ratregion
5072106RH136654183133914493139145114Ratregion
5066596AU048264136133738366937383805Ratregion
5066722AU048189170133672664736726812Ratregion
5066734AU048182164134103325441033418Ratregion
5066848AU048115164133777555937775722Ratregion
5068184AU047298251134139734141397592Ratregion
5068446AU047140128133741422137414349Ratregion
5068884AU046866236133726317937263410Ratregion
5069586AU046399267133847271238472976Ratregion
5060696BE098933153133946341939463572Ratregion
5065540BE115809153133928958539289738Ratregion
5060402BI292164159133872935038729509Ratregion
5060402BI292164159133872935038729509Ratregion
5063104BF398383158133942632839426486Ratregion
5089361AU049110207134025542340255630Ratregion
5081683BF41457692133731880737318899Ratregion
5088425AU048561138133645167436451812Ratregion
5088425AU048561138133645170436451812Ratregion
5085118BQ196234162133896083938961001Ratregion
5088957AU048869132133788794737888081Ratregion
5089095AU048951141133667175336671894Ratregion
5080944RH141873210133925408039254290Ratregion
5085880BQ198886158133929104439291202Ratregion
5505532STS-Z411431080133874424738745331Ratregion
5505532STS-Z411431080133874424738745331Ratregion
5506795G45485299133707800937078308Ratregion
5499717UniSTS:234205210133942853139428741Ratregion
5500707RH71322171133819017038190341Ratregion
Position Markers

Flank 1: (D13Got8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21336,155,723 - 36,155,834 (+)MAPPER
Rnor_6.01341,060,057 - 41,060,167NCBI
Rnor_5.01346,171,139 - 46,171,249UniSTS
RGSC_v3.41337,191,203 - 37,191,314RGD
RGSC_v3.41337,191,204 - 37,191,314UniSTS
RGSC_v3.11337,205,168 - 37,205,279RGD
RH 2.0 Map13206.1RGD
Cytogenetic Map13q11UniSTS
Peak: (D13Arb5)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21337,902,608 - 37,902,821 (-)MAPPER
mRatBN7.21337,902,608 - 37,902,821 (+)MAPPER
Rnor_6.01343,785,727 - 43,785,939NCBI
Rnor_6.01342,794,724 - 42,794,936NCBI
Rnor_5.01348,881,057 - 48,881,269UniSTS
Rnor_5.01347,898,759 - 47,898,971UniSTS
RGSC_v3.41338,985,717 - 38,985,930RGD
RGSC_v3.41338,985,718 - 38,985,930UniSTS
RGSC_v3.11338,999,761 - 38,999,973RGD
Celera1337,690,125 - 37,690,337UniSTS
RH 3.4 Map1375.6UniSTS
RH 3.4 Map1375.6RGD
SHRSP x BN Map137.9399RGD
SHRSP x BN Map137.9399UniSTS
FHH x ACI Map138.9999RGD
Cytogenetic Map13q11UniSTS
Flank 2: (D13Rat19)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21611,442,912 - 11,443,111 (+)MAPPER
mRatBN7.21341,961,224 - 41,961,389 (+)MAPPER
Rnor_6.01347,227,759 - 47,227,923NCBI
Rnor_6.01612,747,329 - 12,747,527NCBI
Rnor_5.01352,281,936 - 52,282,100UniSTS
Rnor_5.01612,641,895 - 12,642,093UniSTS
RGSC_v3.41343,437,202 - 43,437,366UniSTS
RGSC_v3.41343,437,201 - 43,437,366RGD
RGSC_v3.41611,843,545 - 11,843,743UniSTS
Celera1611,704,930 - 11,705,126UniSTS
Celera1342,313,047 - 42,313,211UniSTS
RH 3.4 Map13107.9RGD
RH 3.4 Map13107.9UniSTS
RH 2.0 Map13310.1RGD
SHRSP x BN Map1310.2499RGD
FHH x ACI Map1316.04RGD
Cytogenetic Map13q13UniSTS
Cytogenetic Map16p15UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61453Pur1Proteinuria QTL 118.06urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133453521837415726Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type backcross  
qtl_general number of animals used:167 cohort generated by backcrossing (BUF/Mna x WKY/NCrlj) with BUF/Mna 2292230
qtl_general software package used: MAPMAKER/EXP and MAPMAKER/QTL 2292230
qtl_general this region contains 25 genes; Actr3 is mutated in BUF/Mna 2292230
qtl_general proteinuric rats excreted more than 40mg/day of urinary protein 2292230