Bp299 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Bp299 (Blood pressure QTL 299) Rattus norvegicus

Symbol: Bp299
Name: Blood pressure QTL 299
RGD ID: 1642290
Previously known as: S.LEW BP QTL1
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,230,134 - 69,282,520RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01070,647,089 - 71,727,943RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01070,280,918 - 71,638,303RGDRnor5.0
RGSC_v3.41071,513,116 - 72,685,167RGDRGSC3.4
Cross Type: intercross
Strains Crossed: SS.LEW-(D10Mco84-D10Got93)/Mco 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Ccl5 is a candidate Gene for Bp299
Ddx52 is a candidate Gene for Bp299

Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bp299Ratsystolic blood pressure  IDA 1599269 RGD 

Experimental Condition
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bp299Ratcontrolled sodium content diet  IDA 1599269 RGD 

Measurement Method
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bp299Rattail cuff photoplethysmography  IDA 1599269 RGD 

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bp299RatSS.LEW-(D10Mco84-D10Got93)/Mco  IEA 1599269 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bp299Ratarterial blood pressure trait  IDA 1599269 RGD 

Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Saad Y, etal., Genomics. 2007 Jan 9;.
2. Congenic Interval Mapping of RNO10 Reveals a Complex Cluster of Closely-Linked Genetic Determinants of Blood Pressure. Saad Y, etal., Hypertension. 2007 Sep 24;.
Related QTLs

Related QTL Description Reference
Bp301 sub_region RGD:1642602
Bp300 sub_region RGD:1642602
Bp302 sub_region RGD:1642602


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1597447C10h17orf50similar to human chromosome 17 open reading frame 50106823886068242437Rat
1311573Mmp28matrix metallopeptidase 28106824113868264866Rat
41041079LOC120095158uncharacterized LOC120095158106824623968252736Rat
1309595Taf15TATA-box binding protein associated factor 15106827292168304951Rat
1559875Heatr9HEAT repeat containing 9106830912868320650Rat
69069Ccl5C-C motif chemokine ligand 5106832282668327380Rat
1310563Ccl9C-C motif chemokine ligand 9106836648668371408Rat
9290621LOC103693406uncharacterized LOC103693406106837370368420846Rat
41203172Rpl30-ps12ribosomal protein L30, pseudogene 12106837771268379824Rat
1303200Ccl6C-C motif chemokine ligand 6106838018568385859Rat
3647Ccl3C-C motif chemokine ligand 3106845138868452938Rat
620441Ccl4C-C motif chemokine ligand 4106846639468468229Rat
41059947LOC120095331uncharacterized LOC120095331106848104268483376Rat
6502228Wfdc18l1WAP four-disulfide core domain 18 like 1106853903568541169Rat
41388070LOC120095161uncharacterized LOC120095161106854261068547441Rat
2318138Anos1anosmin 1106856195468562801Rat
619957Wfdc18WAP four-disulfide core domain 18106858881868590972Rat
2318090Anos1-ps1anosmin 1, pseudogene 1106859383768594709Rat
1303147Wfdc21WAP four-disulfide core domain 21106862783668633705Rat
1566204Heatr6HEAT repeat containing 6106863504868665445Rat
3830Hnf1bHNF1 homeobox B106873589468789888Rat
621743Ddx52DExD-box helicase 52106882459468847400Rat
620684Synrgsynergin, gamma106884882868931252Rat
1307415Dusp14dual specificity phosphatase 14106893648368966347Rat
7632735Rps15a-ps2ribosomal protein S15a, pseudogene 2106895205268952509Rat
1309959Tada2atranscriptional adaptor 2A106896650269014149Rat
621248Acacaacetyl-CoA carboxylase alpha106901426169276453Rat
7517962C10h17orf78similar to human chromosome 17 open reading frame 78106903488769054100Rat
41117163Rpl17-ps8ribosomal protein L17, pseudogene 8106905654669057234Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
40444D10Rat220128106888626368886389Ratregion
44761D10Got88170106838312968383299Ratregion
44762D10Got97221106853163468531823Ratregion
44762D10Got97221106855027868550501Ratregion
44764D10Got90212106928093969281151Ratregion
625836D10Got161219106883506368835282Ratregion
62436D10Uia4186106857136068571542Ratregion
66377D7Uia4202106873180368732645Ratregion
1578857D10Chm150219106832055668320777Ratregion
1578862D10Chm149230106830122968301459Ratregion
1631382D10Got241126106853167568531801Ratregion
1631382D10Got241126106855031968550479Ratregion
1631382D10Got241126106855039068550479Ratregion
1578903D10Chm184240106832812368328363Ratregion
1578910D10Chm122196106883209968832295Ratregion
1579042D10Chm185227106844169068441917Ratregion
1579047D10Chm152313106845553468455847Ratregion
1579156D10Chm151197106842769768427896Ratregion
1642081D10Mco89170106928235069282520Ratregion
1642083D10Mco88218106823013468230352Ratregion
1639949D10Got410184106863112368631309Ratregion
7206390Tcf2193106874655268746745Ratregion
5034776AI232002152106866360368663755Ratregion
5029415Tcf2472106873548168735953Ratregion
5027433AI32380497106845165568451752Ratregion
5025724RH129414191106832290768323098Ratregion
5051511AI987804135106878973568789870Ratregion
5049962RH133782206106846793968468145Ratregion
5050750RH134237201106889804268898243Ratregion
5041028RH128621186106838022368380409Ratregion
5044454RH130612183106884704768847230Ratregion
5047602RH132422182106824215068242332Ratregion
5048928RH133187180106903181669031996Ratregion
5041184RH128710214106838077068380984Ratregion
5075810RH138810121106824830868248429Ratregion
5077454RH139765200106896658568966785Ratregion
5077686RH139899195106893357568933770Ratregion
5079834RH141230200106878918868789388Ratregion
5078872RH140600220106884857868848798Ratregion
5073754RH137619232106883952468839756Ratregion
5068164AU047310202106853160168531772Ratregion
5068164AU047310202106855024568550449Ratregion
5069542AU046428210106898237168982576Ratregion
5083917AI175043226106824135668241582Ratregion
5502671Dusp14193106893742268937615Ratregion
5506268D17S610694106903015569030849Ratregion
5500161D11Mit97646106839511268395758Ratregion
5503636UniSTS:46541199106874092868741027Ratregion
5501490D17S1255110106913030669130416Ratregion
Position Markers

Flank 1: (D10Mco88)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21068,230,134 - 68,230,352 (+)MAPPER
Rnor_6.01070,647,089 - 70,647,306NCBI
Rnor_5.01071,109,113 - 71,109,330UniSTS
Rnor_5.01070,280,918 - 70,281,135UniSTS
RGSC_v3.41071,513,116 - 71,513,333UniSTS
Celera1067,171,651 - 67,171,868UniSTS
Cytogenetic Map10q26UniSTS
Flank 2: (D10Mco89)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21069,282,350 - 69,282,520 (+)MAPPER
Rnor_6.01071,727,774 - 71,727,943NCBI
Rnor_5.01071,638,135 - 71,638,303UniSTS
RGSC_v3.41072,684,998 - 72,685,167UniSTS
Celera1068,209,299 - 68,209,468UniSTS
Cytogenetic Map10 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642290Bp299Blood pressure QTL 299arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106823013469282520Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general number of animals used: 20 congenics and 20 SS/Jr as control 1599269
qtl_general this QTL contains 18 genes none of which play a role in blood pressure control hence this region holds potential genetic factors that control blood pressure 1599269
qtl_general gender: male 1599269
qtl_general details of the measurement method: systolic blood pressure was measured by the tail-cuff method at 40-42 days of age for 4 days once a day and the average of three readings taken as Bp value 1599269