Niddm64 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Niddm64 (Non-insulin dependent diabetes mellitus QTL 64) Rattus norvegicus

Symbol: Niddm64
Name: Non-insulin dependent diabetes mellitus QTL 64
RGD ID: 1600390
Previously known as: Niddm1i2
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: Not Available
P Value: 0.003
Variance: 4.0
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21247,683,763 - 248,192,604RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01268,570,074 - 269,078,983RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01276,009,949 - 276,520,579RGDRnor5.0
RGSC_v3.41254,291,806 - 254,810,043RGDRGSC3.4
RGSC_v3.11254,556,550 - 268,121,971RGD
Cross Type: Not Available
Strains Crossed: F344.GK-(D1Rat175-D1Rat90)/Swe F344.GK-(D1Rat83-D1Rat376)/Swe 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Sorcs3 is a candidate Gene for Niddm64

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat. Granhall C, etal., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1.
2. Identification of genetic loci involved in diabetes using a rat model of depression. Solberg Woods LC, etal., Mamm Genome. 2009 Aug 22.
Related QTLs

Related QTL Description Reference
Gluco51 maps to same region RGD:2312611


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1310974Sorcs3sortilin-related VPS10 domain containing receptor 31247099178247734027Rat
7531295LOC102553570uncharacterized LOC1025535701248166322248202658Rat
41147363LOC120100052uncharacterized LOC1201000521247854390247857655Rat
41295772LOC120100408small nucleolar RNA SNORA481247861966247862109Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
43443D1Got2471221247683763247683883Ratregion
629596D1Hmgc31541247779589247779743Ratregion
1600318D1Swe22041247865838247866042Ratregion
1600322D1Swe32581248192346248192604Ratregion
5027179SHGC-1520962231248109316248109539Ratregion
5527390D1Hmgc211931248138231248138424Ratregion
Position Markers

Flank 1: (D1Got247)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21247,683,763 - 247,683,883 (+)MAPPER
Rnor_6.01268,570,074 - 268,570,193NCBI
Rnor_5.01276,009,949 - 276,010,068UniSTS
RGSC_v3.41254,291,806 - 254,291,924RGD
RGSC_v3.41254,291,807 - 254,291,926UniSTS
RGSC_v3.11254,556,550 - 254,556,668RGD
Celera1243,431,391 - 243,431,510UniSTS
RH 3.4 Map11647.7UniSTS
RH 3.4 Map11647.7RGD
RH 2.0 Map11250.7RGD
Cytogenetic Map1q54-q55UniSTS
Peak: (D1Swe2)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21247,865,838 - 247,866,042 (+)MAPPER
Rnor_6.01268,752,165 - 268,752,368NCBI
Rnor_5.01276,192,826 - 276,193,029UniSTS
RGSC_v3.41254,478,208 - 254,478,411UniSTS
Celera1243,613,157 - 243,613,367UniSTS
Cytogenetic Map1 RGD
Flank 2: (D1Swe3)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21248,192,346 - 248,192,604 (+)MAPPER
Rnor_6.01269,078,726 - 269,078,983NCBI
Rnor_5.01276,520,322 - 276,520,579UniSTS
RGSC_v3.41254,809,786 - 254,810,043UniSTS
Celera1243,934,123 - 243,934,371UniSTS
Cytogenetic Map1 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1247683763248192604Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general software: single marker QTL analysis was performed using Minitab 1599587
qtl_general gender: 95 days old males 1599587
qtl_general allele: GK allele (500 kb) is responsible for the glucose-raising effect 1599587
qtl_general measurement method: intraperitoneal glucose tolerance test (IPGTT) was performed with 2.0 g glucose/kg body weight without anesthesia after 6 hr fasting 1599587