Niddm66 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Niddm66 (Non-insulin dependent diabetes mellitus QTL 66) Rattus norvegicus

Symbol: Niddm66
Name: Non-insulin dependent diabetes mellitus QTL 66
RGD ID: 1600384
Previously known as: Niddm1i4
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: Not Available
P Value: 5.0E-6
Variance: 9.6
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21252,645,447 - 253,439,819RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01274,353,782 - 275,138,914RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01281,763,458 - 282,550,389RGDRnor5.0
RGSC_v3.41259,866,528 - 260,641,846RGDRGSC3.4
RGSC_v3.11215,852,891 - 260,852,891RGD
Cross Type: Not Available
Strains Crossed: F344.GK-(D1Got250-D1Rat90)/Swe F344.GK-(D1Rat175-D1Rat90)/Swe 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat. Granhall C, etal., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1.
2. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Rosengren AH, etal., Science. 2010 Jan 8;327(5962):217-20. Epub 2009 Nov 19.
3. Identification of genetic loci involved in diabetes using a rat model of depression. Solberg Woods LC, etal., Mamm Genome. 2009 Aug 22.
Related QTLs

Related QTL Description Reference
Gluco51 maps to same region RGD:2312611


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
620816Pdcd4programmed cell death 41252921342252944278Rat
1307427Rbm20RNA binding motif protein 201252683760252907465Rat
1308146Shoc2SHOC2 leucine-rich repeat scaffold protein1252958939253048820Rat
2056Adra2aadrenoceptor alpha 2A1253061480253064280Rat
6498801Bbip1BBSome interacting protein 11252943589252959512Rat
41188207LOC120100368small nucleolar RNA SNORA201252970938252971065Rat
41268475LOC120100059uncharacterized LOC1201000591253197596253204527Rat
41301989LOC120100058uncharacterized LOC1201000581252872519252877817Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10097D1Smu21291253050519253050648Ratregion
43448D1Got2511661253439653253439819Ratregion
1600324D1Swe82101252645447252645657Ratregion
5026840RH1337312031252943433252944252Ratregion
5051935RH947431701253050475253050643Ratregion
5056203RH1442432921253099772253100064Ratregion
5056327RH1443141111252944762252944873Ratregion
5055641RH1439181821252683081252683263Ratregion
5077838RH1399891801253063937253064117Ratregion
5080470RH1415971811252883185252883366Ratregion
5062172BE1128772041252942920252943124Ratregion
5060904BF3959462111252973518252973729Ratregion
5063660BE1079302131252998768252998981Ratregion
5060790BF3891461601253049767253049927Ratregion
5086284BQ2061422171253050868253051086Ratregion
550015917.MMHAP36FRF8.seq11741252666801252667975Ratregion
Position Markers

Flank 1: (D1Swe8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21252,645,447 - 252,645,657 (+)MAPPER
Rnor_6.01274,353,782 - 274,353,991NCBI
Rnor_5.01281,763,458 - 281,763,667UniSTS
RGSC_v3.41259,866,528 - 259,866,737UniSTS
Celera1248,364,546 - 248,364,755UniSTS
Cytogenetic Map1 RGD
Peak: (D1Smu2)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21253,050,519 - 253,050,648 (+)MAPPER
Rnor_6.01274,755,723 - 274,755,851NCBI
Rnor_5.01282,168,252 - 282,168,380UniSTS
Celera1248,764,527 - 248,764,655UniSTS
Flank 2: (D1Got251)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21253,439,653 - 253,439,819 (+)MAPPER
Rnor_6.01275,138,749 - 275,138,914NCBI
Rnor_5.01282,550,224 - 282,550,389UniSTS
RGSC_v3.41260,641,680 - 260,641,846RGD
RGSC_v3.41260,641,681 - 260,641,846UniSTS
RGSC_v3.11260,852,726 - 260,852,891RGD
Celera1249,150,158 - 249,150,323UniSTS
RH 3.4 Map11685.3UniSTS
RH 3.4 Map11685.3RGD
RH 2.0 Map11280.8999RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1600384Niddm66Non-insulin dependent diabetes mellitus QTL 660.000005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1252645447253439819Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general measurement method: intraperitoneal glucose tolerance test (IPGTT) was performed with 2.0 g glucose/kg body weight without anesthesia after 6 hr fasting 1599587
qtl_general gender: 95 days old males 1599587
qtl_general highly significant for postprandial glucose at 15 min also colocalises with postprandial glucose at 30 min 1599587
qtl_general GK allele is responsible for higher postrpandial glucose level 1599587
qtl_general software: single marker QTL analysis was performed using Minitab 1599587