Mcs22 QTL Report (Rattus norvegicus) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
QTL Registration

QTL: Mcs22 (Mammary carcinoma susceptibility QTL 22) Rattus norvegicus

Symbol: Mcs22
Name: Mammary carcinoma susceptibility QTL 22
RGD ID: 1600375
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor growth rate   (CMO:0000344)    
LOD Score: 3.3
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21852,539,763 - 63,933,058RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01854,108,375 - 68,819,562RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01853,346,348 - 67,970,489RGDRnor5.0
RGSC_v3.41854,856,551 - 67,024,547RGDRGSC3.4
RGSC_v3.11854,928,784 - 67,097,748RGD
Cross Type: backcross
Strains Crossed: WKY/Ztm SPRD/Ztm 



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
SPRD/Ztm  (IEA)
WKY/Ztm  (IEA)

References

References - curated
# Reference Title Reference Citation
1. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Cotroneo MS, etal., Oncogene. 2006 Aug 17;25(36):5011-7. Epub 2006 Mar 27.
2. Contrasting epistatic interactions between rat quantitative trait loci controlling mammary cancer development. Piessevaux G, etal., Mamm Genome. 2008 Dec 4.
3. Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat. Quan X, etal., Mamm Genome. 2006 Apr;17(4):310-21. Epub 2006 Apr 4.

Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Flank 1: (D18Rat55)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21852,539,763 - 52,539,863 (+)MAPPER
Rnor_6.01854,108,375 - 54,108,474NCBI
Rnor_5.01853,346,348 - 53,346,447UniSTS
RGSC_v3.41854,856,551 - 54,856,651RGD
RGSC_v3.41854,856,552 - 54,856,651UniSTS
RGSC_v3.11854,928,784 - 54,928,883RGD
Celera1850,643,852 - 50,643,951UniSTS
RH 3.4 Map18497.9RGD
RH 3.4 Map18497.9UniSTS
RH 2.0 Map18411.9RGD
SHRSP x BN Map1822.7899RGD
FHH x ACI Map1831.46RGD
Cytogenetic Map18q12.1UniSTS
Peak: (D18Rat14)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21863,932,885 - 63,933,058 (+)MAPPER
Rnor_6.01868,819,390 - 68,819,562NCBI
Rnor_5.01867,970,317 - 67,970,489UniSTS
RGSC_v3.41867,024,317 - 67,024,489UniSTS
RGSC_v3.41867,024,128 - 67,024,547RGD
RGSC_v3.11867,097,329 - 67,097,748RGD
Celera1862,007,007 - 62,007,179UniSTS
SHRSP x BN Map1838.7499UniSTS
SHRSP x BN Map1838.7499RGD
Flank 2: (D18Rat14)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21863,932,885 - 63,933,058 (+)MAPPER
Rnor_6.01868,819,390 - 68,819,562NCBI
Rnor_5.01867,970,317 - 67,970,489UniSTS
RGSC_v3.41867,024,317 - 67,024,489UniSTS
RGSC_v3.41867,024,128 - 67,024,547RGD
RGSC_v3.11867,097,329 - 67,097,748RGD
Celera1862,007,007 - 62,007,179UniSTS
SHRSP x BN Map1838.7499UniSTS
SHRSP x BN Map1838.7499RGD


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type backcross  
qtl_general number of animals used: 187 1599317
qtl_general gender: 53-58 days old virgin females 1599317
qtl_general allele responsible: WKY allele reduces aggressiveness 1599317
qtl_general inducing agent and dosage: single dosage of DMBA, 65mg/kg 1599317