Iddm24 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Iddm24 (Insulin dependent diabetes mellitus QTL 24) Rattus norvegicus

Symbol: Iddm24
Name: Insulin dependent diabetes mellitus QTL 24
RGD ID: 1599689
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: age at onset/diagnosis of type 1 diabetes mellitus   (CMO:0001140)    
LOD Score: 4.72
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28112,834,440 - 118,649,220RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.08120,870,965 - 127,609,447RGD_MAPPER_PIPELINERnor6.0
Rnor_5.08121,647,985 - 126,827,827RGDRnor5.0
RGSC_v3.48118,705,293 - 123,876,328RGDRGSC3.4
RGSC_v3.18120,550,558 - 123,895,808RGD
Cross Type: Not Available
Strains Crossed: BBDP.WF-(D8Rat59-D8Sunn1467)/Sunn 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Unpublished observations for Iddm QTL Personal communication with Dr. Wallis
2. A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes. Wallis RH, etal., Diabetes. 2007 Jun;56(6):1731-6. Epub 2007 Mar 27

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2320736Skint1-ps1selection and upkeep of intraepithelial T cells 1, pseudogene 18112840716112841470Rat
40975319LOC120094386uncharacterized LOC1200943868112976474112977512Rat
7545262LOC102553940uncharacterized LOC1025539408113033104113051792Rat
7610822LOC102554058uncharacterized LOC1025540588113128960113137339Rat
7501656LOC102554003uncharacterized LOC1025540038113170377113194795Rat
41143523LOC120094271uncharacterized LOC1200942718113181946113186562Rat
41388075LOC120094272uncharacterized LOC1200942728113250732113254017Rat
11412166LOC108351784uncharacterized LOC1083517848113254101113259069Rat
7505909LOC102554279uncharacterized LOC1025542798113279948113338417Rat
41347543LOC120094273uncharacterized LOC1200942738113375472113393264Rat
40987280LOC120094274uncharacterized LOC1200942748113479098113516776Rat
68357Pdcd6ipprogrammed cell death 6 interacting protein8113590998113646795Rat
6498658LOC100910424uncharacterized LOC1009104248113645861113650490Rat
619789Clasp2cytoplasmic linker associated protein 28113677345113859957Rat
40964733LOC120094511small nucleolar RNA SNORA178113714597113714719Rat
41186188LOC120094275uncharacterized LOC1200942758113858373113862928Rat
41343709LOC120094276uncharacterized LOC1200942768113868982113869740Rat
1564700Ubp1upstream binding protein 18113869771113915625Rat
1562243Fbxl2F-box and leucine-rich repeat protein 28113916660113965137Rat
7740190Cops7b-ps1COP9 signalosome subunit 7B, pseudogene 18113955342113956371Rat
1561132Susd5sushi domain containing 58113996771114036133Rat
41307598LOC120094403U6 spliceosomal RNA8113999835113999934Rat
1565180Crtapcartilage associated protein8114047929114067636Rat
41390010LOC120094423U6 spliceosomal RNA8114072690114072793Rat
7696429Tmppetransmembrane protein with metallophosphoesterase domain8114085497114093388Rat
1597145Glb1galactosidase, beta 18114085508114158127Rat
41344787LOC120094277uncharacterized LOC1200942778114132501114133511Rat
620594Ccr4C-C motif chemokine receptor 48114176291114182033Rat
1566388Trim71tripartite motif containing 718114193439114250807Rat
40982232LOC120094278uncharacterized LOC1200942788114235156114237731Rat
1359219Cnot10CCR4-NOT transcription complex, subunit 108114280486114330110Rat
11360003Rpl30-ps11ribosomal protein L30, pseudogene 118114281765114282153Rat
41292084LOC120094421U6 spliceosomal RNA8114290603114290706Rat
41253696LOC120094531U2 spliceosomal RNA8114318753114318857Rat
6495655LOC100910986uncharacterized LOC1009109868114367875114370158Rat
71072Dync1li1dynein cytoplasmic 1 light intermediate chain 18114376649114410297Rat
1307765Cmtm6CKLF-like MARVEL transmembrane domain containing 68114422934114441034Rat
1591926Cmtm7CKLF-like MARVEL transmembrane domain containing 78114448037114474958Rat
735040Cmtm8CKLF-like MARVEL transmembrane domain containing 88114481730114547107Rat
41044483LOC120094408U6 spliceosomal RNA8114531745114531851Rat
1560123Gpd1l1glycerol-3-phosphate dehydrogenase 1 like 18114591103114620771Rat
1561652Osbpl10oxysterol binding protein-like 108114661050114918664Rat
11471062LOC108351789uncharacterized LOC1083517898114694046114716340Rat
41363723LOC120094279uncharacterized LOC1200942798114862356114874520Rat
1311563Stt3bSTT3 oligosaccharyltransferase complex catalytic subunit B8114928678114994027Rat
7660389LOC102557192uncharacterized LOC1025571928115002763115016548Rat
41172090LOC120094443small nucleolar RNA SNORD348115045817115045883Rat
11459128LOC108351790uncharacterized LOC1083517908115050638115063990Rat
41021311LOC120094280uncharacterized LOC1200942808115080336115084333Rat
11451285LOC108351855uncharacterized LOC1083518558115102013115103040Rat
41188693LOC120094281uncharacterized LOC1200942818115136926115138426Rat
40966228LOC120094282uncharacterized LOC1200942828115155632115161786Rat
11481686LOC108351791uncharacterized LOC1083517918115203154115214740Rat
41362088LOC120094387uncharacterized LOC1200943878115306199115308500Rat
41309720LOC120094283uncharacterized LOC1200942838115532342115545076Rat
1565145Gadl1glutamate decarboxylase-like 18115605609115785676Rat
69651Tgfbr2transforming growth factor, beta receptor 28115794537115883615Rat
40957251LOC120094284uncharacterized LOC1200942848115898962115904437Rat
9334455LOC103690469uncharacterized LOC1036904698115948233115954215Rat
41062045LOC120094285uncharacterized LOC1200942858116006288116023243Rat
7546114LOC102549861uncharacterized LOC1025498618116024861116055484Rat
7520837LOC102549917uncharacterized LOC1025499178116057745116073944Rat
41072985LOC120094286uncharacterized LOC1200942868116092008116141431Rat
1588240Rbms3RNA binding motif, single stranded interacting protein 38116305227117625730Rat
41202544LOC120094352uncharacterized LOC1200943528116529859116536417Rat
7680874LOC102550774uncharacterized LOC1025507748116991164117014673Rat
41033264Vdac2-ps5voltage-dependent anion channel 2, pseudogene 58117186885117191355Rat
11368915LOC108351793uncharacterized LOC1083517938117262356117269317Rat
7600507LOC102550472uncharacterized LOC1025504728117300159117301098Rat
41291436LOC120093118uncharacterized LOC1200931188117458385117463193Rat
41306037LOC12009435140S ribosomal protein S16-like8117507399117510061Rat
1596709Zcwpw2zinc finger CW-type and PWWP domain containing 28117628838117773096Rat
41385884LOC120094353uncharacterized LOC1200943538117652733117655704Rat
1310530Azi25-azacytidine induced 28117773248117797844Rat
1305283Cmc1C-x(9)-C motif containing 18117798036117900458Rat
41187623LOC120094354uncharacterized LOC1200943548117857770117868921Rat
11503004LOC108351794uncharacterized LOC1083517948117900784117908687Rat
7518685LOC102547938uncharacterized LOC1025479388118053602118057849Rat
7621173LOC102548091uncharacterized LOC1025480918118086514118094487Rat
1359706Eomeseomesodermin8118181340118189186Rat
1591925Golga4golgin A48118208200118285003Rat
1311191Itga9integrin subunit alpha 98118307424118615527Rat
41322261Trnaa-ggc2transfer RNA alanine (anticodon GGC) 28118380515118380595Rat
1304841CtdsplCTD small phosphatase like8118642729118767238Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
34489D2Mgh41478118377666118377831Ratregion
34489D2Mgh41478118377666118378107Ratregion
34489D2Mgh41478118377781118377831Ratregion
33751D8Mit111378116824149116824306Ratregion
36267D8Rat83298113310201113310524Ratregion
36327D8Rat21388118218931118219066Ratregion
35429D8Rat71688116035272116035431Ratregion
37138D8Rat62328117151942117152154Ratregion
35761D8Rat51258117769315117769440Ratregion
39624D8Rat1182148118649006118649220Ratregion
39856D8Rat1171688116875123116875281Ratregion
38140D8Rat722048114019644114019816Ratregion
40370D8Rat1221758113698073113698250Ratregion
40452D8Rat1731588114821007114821151Ratregion
40150D8Rat1201678115071833115072004Ratregion
38976D2Rat1242158116760064116760124Ratregion
42875D8Rat2002298114435431114435660Ratregion
41446D8Rat1191728115741740115741920Ratregion
44544D8Got1952758118324174118324442Ratregion
44526D8Got1781418113974178113974319Ratregion
44529D8Got1901698115396229115396398Ratregion
44530D8Got2142808115876703115876983Ratregion
44531D8Got2151578115892258115892415Ratregion
44532D8Got1912708117250258117250530Ratregion
44537D8Got1931568118302732118302888Ratregion
60601D8Got1672058118324105118324310Ratregion
60610D8Got1892068115536710115536916Ratregion
1630270D8Got3251258114013482114013607Ratregion
1627553D8Sunn12198116222186116222405Ratregion
1627561D8Sunn92028116735896116736098Ratregion
1628266D8Got3141758115733871115734046Ratregion
1628596D8Got3261328114662288114662415Ratregion
1638893D8Got3561828113144832113145014Ratregion
1638971D8Got3503258114953847114954170Ratregion
1632580D8Got3272628114262443114262705Ratregion
1636198D8Got3131588113329283113329441Ratregion
1634177D8Got3381138115886669115886782Ratregion
5039182RH1275592208113593711113593931Ratregion
5026072RH1308012208114157310114157530Ratregion
5026142RH1310741848117797556117797742Ratregion
5031556AU0479382198114262499114262718Ratregion
5034273RH1420162008113648822113649022Ratregion
5031798AU0471111728118322812118322984Ratregion
5029083RH1434541128118222454118222585Ratregion
5032173RH1261312188118188919118189137Ratregion
5032515D9Ertd428e2208118611924118612144Ratregion
5030649BF4040191758116453718116453891Ratregion
5025624RH1290341508113915454113915604Ratregion
5056103RH1441841858114381814114381999Ratregion
5056315RH1443071558118308441118308596Ratregion
5056489RH1444081378113859666113859803Ratregion
5058866BE1025161788118583600118583778Ratregion
5052490C763642178113593843113594060Ratregion
5050008RH1338091508114369981114370131Ratregion
5049978RH1337912128118615206118615416Ratregion
5051060RH1344152208114193553114193773Ratregion
5044534RH1306581828114280572114280754Ratregion
5041834RH1290851968114440773114440969Ratregion
5044720RH1307652098113911167113911376Ratregion
5044830RH1308281928114893573114893765Ratregion
5039560RH1277752028114410621114410823Ratregion
5048382RH1328711508116305291116305441Ratregion
5039706RH1278601918114440605114440796Ratregion
5048602RH1329981978118311842118312042Ratregion
5040290RH1281982048117458526117458730Ratregion
5042142RH1292641828114448123114448305Ratregion
5042158RH1292731628114448098114448260Ratregion
5043184RH1298802128118285031118285243Ratregion
5042624RH1295462038118188867118189070Ratregion
5041244RH1287452208114482021114482241Ratregion
5076650RH1392991608118248509118248669Ratregion
5077610RH1398551858115785321115785506Ratregion
5080082RH1413721918116307251116307442Ratregion
5073068RH1372171938114927384114927577Ratregion
5071218RH1349561868117799709117799895Ratregion
5071266RH1349831988114095665114095863Ratregion
5073670RH1375711208115353635115353755Ratregion
5074848RH1382531388118260645118260783Ratregion
5063350BF4041402058113767832113768037Ratregion
5066614AU0482531238118348837118348960Ratregion
5068018AU0473982268118023372118023403Ratregion
5068168AU0473071278112945979112946106Ratregion
5069540AU0464292258114262473114262699Ratregion
5069044AU0467601118114187884114187991Ratregion
5069112AU0467151988117976850117977048Ratregion
5069864AU0467901798118059246118059425Ratregion
5060268AW5310361528116684582116684734Ratregion
5062372BF3978261958113789772113789966Ratregion
5065614BF4126112228113922884113923106Ratregion
5064336BE1144261608118646082118646242Ratregion
5061386BE0997421558116997008116997163Ratregion
5061388BF3963111458114925200114925345Ratregion
5084214AI2335001048115009979115010083Ratregion
5086933BF4106791148114866131114866245Ratregion
5082161BI2801251678114048021114048188Ratregion
5087094AI7152971418115796930115797071Ratregion
5086421BE1150321728114196283114196455Ratregion
5082797BF3901261508113859026113859176Ratregion
5090799AU0499702998115743453115744566Ratregion
5088773AU0487671178117307063117307182Ratregion
5089977AU0494762908118506481118506771Ratregion
5086024BM3838631518114790730114790881Ratregion
5081032RH1419252148116308555116308769Ratregion
5082883BF3903221828113767928113768110Ratregion
5083473BI2823621718114048134114048305Ratregion
5502629RH1259332508117797521117797771Ratregion
5506961fc28a01.x108117965215117965675Ratregion
5506961fc28a01.x108117965237117965675Ratregion
5500033UniSTS:2362691028114393882114393984Ratregion
5499493stSG59873111138114848415114849530Ratregion
5500559RH1359931698118285100118285269Ratregion
Position Markers

Flank 1: (D8Rat121)
Rat AssemblyChrPosition (strand)Source
Rnor_5.08121,647,985 - 121,648,073NCBI
RGSC_v3.48118,705,293 - 118,705,380RGD
RGSC_v3.18118,724,748 - 118,724,835RGD
SHRSP x BN Map876.2399RGD
SHRSP x BN Map876.2399UniSTS
Peak: (D8Rat119)
Rat AssemblyChrPosition (strand)Source
mRatBN7.28115,741,740 - 115,741,920 (+)MAPPER
Rnor_6.08124,240,117 - 124,240,296NCBI
Rnor_5.08123,517,546 - 123,517,725UniSTS
RGSC_v3.48120,530,641 - 120,530,821RGD
RGSC_v3.48120,530,642 - 120,530,821UniSTS
RGSC_v3.18120,550,379 - 120,550,558RGD
Celera8114,955,855 - 114,956,034UniSTS
RH 3.4 Map81227.6RGD
RH 3.4 Map81227.6UniSTS
RH 2.0 Map8982.3RGD
SHRSP x BN Map877.3899RGD
Cytogenetic Map8q32UniSTS
Flank 2: (D8Rat118)
Rat AssemblyChrPosition (strand)Source
mRatBN7.28118,649,006 - 118,649,220 (+)MAPPER
Rnor_6.08127,609,234 - 127,609,447NCBI
Rnor_5.08126,827,614 - 126,827,827UniSTS
RGSC_v3.48123,875,958 - 123,876,328RGD
RGSC_v3.48123,876,071 - 123,876,284UniSTS
RGSC_v3.18123,895,808 - 123,896,021RGD
Celera8117,824,315 - 117,824,528UniSTS
RH 3.4 Map81292.1RGD
RH 3.4 Map81292.1UniSTS
RH 2.0 Map8999.3RGD
SHRSP x BN Map881.87RGD
Cytogenetic Map8q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
1599689Iddm24Insulin dependent diabetes mellitus QTL 244.720.001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)8112834440118649220Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general this locus is specific for spontaneous type 1 diabetes 1624306
qtl_general LOD 2.92 was noted for type 1 diabetes (p<0.05) 1624306
qtl_general number of animals used: 134 F2 (BBDP X double congenics) and a panel of congenics 1624306
qtl_general this QTL maps to telomeric 10.34 Mb 1624306
qtl_general inducing agent: poly I:C (1/g body wt intraperitoneally three times per week) and DS4.23, an anti-ART2.1mAb( 50 micrograms intraperitoneally five times per week) was given to induce diabetes 1624306
qtl_general software used: MAPMAKER/EXPv3.0 1624306
qtl_general this locus affects spontaneous type 1 diabetes but not experimentally-induced type 1 diabetes 1624306