Mcs14 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Mcs14 (Mammary carcinoma susceptibility QTL 14) Rattus norvegicus

Symbol: Mcs14
Name: Mammary carcinoma susceptibility QTL 14
RGD ID: 1598845
Previously known as: Mcs5c
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor number   (CMO:0000343)    
LOD Score: Not Available
P Value: 1.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2576,369,776 - 80,813,390RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0578,777,540 - 83,269,259RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0582,897,463 - 87,363,048RGDRnor5.0
RGSC_v3.4579,919,505 - 84,434,576RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: WF.WKY-(D5Uwm68-D5Mit4)/Uwm 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mammary tumor number  IDA 1559294 RGD 

Experimental Condition
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
7,12-dimethyltetraphene (DMBA)  IDA 1559294 RGD 

Measurement Method
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
in vivo visual assessment  IDA 1559294 RGD 

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
WF.WKY-(D5Uwm68-D5Mit4)/Uwm  IEA 1559294 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mammary gland integrity trait  IDA 1559294 RGD 

Disease Annotations     Click to see Annotation Detail View

Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5. Samuelson DJ, etal., Cancer Res. 2005 Nov 1;65(21):9637-42.
2. Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression. Veillet AL, etal., Cancer Prev Res (Phila). 2011 Jan;4(1):97-106.
Related QTLs

Related QTL Description Reference
Mcs29 sub_region RGD:5684388
Mcs28 sub_region RGD:5684388


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
67390Orm1orosomucoid 157676663776776149Rat
2102Ambpalpha-1-microglobulin/bikunin precursor57656809476578416Rat
3870Tlr4toll-like receptor 458014586780159501Rat
631330Whrnwhirlin57682830876911945Rat
628735Tnfsf15TNF superfamily member 1557713488577156171Rat
621057Tnctenascin C57737585177460712Rat
1304595Tmem268transmembrane protein 26857697482777001457Rat
735115Col27a1collagen type XXVII alpha 1 chain57664730276765989Rat
1307742Pappapappalysin57849766078735873Rat
1310743Zfp618zinc finger protein 61857639851476564837Rat
1305238Trim32tripartite motif-containing 3257900513979016615Rat
1308487Kif12kinesin family member 1257659620476603261Rat
1310088Atp6v1g1ATPase H+ transporting V1 subunit G157696146276967642Rat
1308202AknaAT-hook transcription factor57677741576824380Rat
1560180Eno1-ps16enolase 1, pseudogene 1657823847878242959Rat
1584073Tex48testis expressed 4857701716777033673Rat
1586184Gapdh-ps110Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 11057709206177094437Rat
1590403Tnfsf8TNF superfamily member 857725094277277364Rat
1593269Rpl13-ps6ribosomal protein L13, pseudogene 658078316180783785Rat
1593270tuba1c-ps3tubulin, alpha 1C, pseudogene 357767917177681447Rat
2320342Astn2astrotactin 257875814279744021Rat
2325417Mir455microRNA 45557668931376689390Rat
7695413LOC102547858uncharacterized LOC10254785857680748576814704Rat
7697789LOC102553131uncharacterized LOC10255313157700793877011175Rat
9234855LOC103692377uncharacterized LOC10369237757750867977564182Rat
11371333LOC108350984U6 snRNA-associated Sm-like protein LSm6 pseudogene57714581477155846Rat
11400923LOC108351093H/ACA ribonucleoprotein complex subunit 3 pseudogene57693498976936468Rat
41251418LOC120103186U6 spliceosomal RNA58035941580359521Rat
41206721LOC120103331small nucleolar RNA SNORA1757782081177820944Rat
41173321H2az2-ps2H2A.Z variant histone 2, pseudogene 257972162879721952Rat
41095319LOC120103275small nucleolar RNA SNORA4458024866580248782Rat
41102148LOC120103204U6 spliceosomal RNA57704088277040985Rat
41199365Rnu6-1015RNA, U6 small nuclear 101557930709979307205Rat
40946078LOC120103154uncharacterized LOC12010315457816128078184113Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
34170D5Mgh2412457830912778309253Ratregion
34953D5Rat1515257710834477108498Ratregion
42749D5Rat23024157944341179443657Ratregion
41206D5Rat14614957733153277331679Ratregion
43906D5Got1023457645349476453730Ratregion
43907D5Got1221557747701677477231Ratregion
43908D5Got1125857749607877496333Ratregion
43909D5Got1427857780413377804411Ratregion
43910D5Got1527657821351378213789Ratregion
43911D5Got1917557793466977934844Ratregion
43913D5Got1715557895312778953282Ratregion
43914D5Got1816657903139279031558Ratregion
43915D5Got1613457961481279614946Ratregion
60477D5Got1312357764058877640711Ratregion
69511D5Uwm2113257720142777201563Ratregion
69513D5Uwm2213757834116978341308Ratregion
67274D5Arb826257677548776775749Ratregion
1582002D5Uwm6127458081311680813390Ratregion
1582044D5Uwm6727257636977676370048Ratregion
1638901D5Got3139857793469977934797Ratregion
1636654D5Got29016457907160179071767Ratregion
5035889PMC289161P130458015854480158848Ratregion
5034440BE11805415057873351378733663Ratregion
5027271AI59701312057677752476777644Ratregion
5032879RH13682313857676574076765878Ratregion
502785513.MHAa96b1.seq11857723904077239158Ratregion
5025512RH12860719257700105777001249Ratregion
5051813RH9467317357677620276776374Ratregion
5059364AW53033214457682847076828614Ratregion
5051374AI50513914557656364676563791Ratregion
5050588RH13414318057684113076841310Ratregion
5051815RH9467418057677259276772772Ratregion
5043452RH13003318057737596177376141Ratregion
5044714RH13076218258016089980161081Ratregion
5048288RH13281619957902038079020577Ratregion
5075012RH13834813457699997477000108Ratregion
5075042RH13836519857680589476806092Ratregion
5075154RH13843022857677473976776114Ratregion
5076726RH13934313257872310578723237Ratregion
5079708RH14115718657696730076967486Ratregion
5071420RH13507220657756384877564054Ratregion
5072474RH13687020757659625476596461Ratregion
5064236BE12082921757872980378730020Ratregion
5060886BI28681812257957986879579990Ratregion
5066094BE11680915257667077276670924Ratregion
5063040BF39828018357901890379019086Ratregion
5089575AU04923717157926627979266450Ratregion
5085433BE09684617957696927876969457Ratregion
5085222Tlr417858015806080158238Ratregion
5085677AW52687012257656466676564788Ratregion
5085808BF38741715157900872979008880Ratregion
5505134Ambp9857657284776573596Ratregion
5505352Atp6v1g114857696543276966960Ratregion
5499841UniSTS:23494015657901489779015053Ratregion
5503490ZNF618__471460257655853076559132Ratregion
6904163D5Uwm7730057752186077522160Ratregion
6904165D5Uwm7826357754076277541025Ratregion
6904167D5Uwm7924757758593877586187Ratregion
6904169D5Uwm8028357763271877633001Ratregion
6904171D5Uwm8127457771465477714928Ratregion
6904173D5Uwm8227457774323977743513Ratregion
6904175D5Uwm8329057778640477786694Ratregion
6904177D5Uwm8427657779107677791352Ratregion
6904177D5Uwm8427657779107677791604Ratregion
6904177D5Uwm8427657779124077791352Ratregion
6904179D5Uwm8525457781615577816409Ratregion
6904181D5Uwm8629357781946577819841Ratregion
6904181D5Uwm8629357781954877819841Ratregion
6904183D5Uwm8721157796053577960746Ratregion
6904185D5Uwm8825657798860477988860Ratregion
6904187D5Uwm8922057799815177998371Ratregion
6904189D5Uwm9021957800587678006099Ratregion
6904191D5Uwm9121557801870678018921Ratregion
6904193D5Uwm9224257803884078039084Ratregion
6904195D5Uwm9317857810195878102136Ratregion
6904197D5Uwm9414657819183078191978Ratregion
6904199D5Uwm9526257855420578554465Ratregion
6904201D5Uwm9628757866221078662497Ratregion
6904203D5Uwm9727557961821779618492Ratregion
6904205D5Uwm9822158014535980145576Ratregion
Position Markers

Flank 1: (D5Uwm67)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2576,369,776 - 76,370,048 (+)MAPPER
Rnor_6.0578,777,540 - 78,777,811NCBI
Rnor_5.0582,897,463 - 82,897,734UniSTS
RGSC_v3.4579,919,505 - 79,919,776UniSTS
Celera575,308,598 - 75,308,853UniSTS
Cytogenetic Map5 RGD
Flank 2: (D5Uwm61)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2580,813,116 - 80,813,390 (+)MAPPER
Rnor_6.0583,268,986 - 83,269,259NCBI
Rnor_5.0587,362,775 - 87,363,048UniSTS
RGSC_v3.4584,434,303 - 84,434,576UniSTS
Celera579,697,693 - 79,697,968UniSTS
Cytogenetic Map5 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1598845Mcs14Mammary carcinoma susceptibility QTL 140.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)57636977680813390Rat
6907110Mcs28Mammary carcinoma susceptibility QTL 28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)57774323978039084Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)57781615577988860Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-30 Mcs14  Mammary carcinoma susceptibility QTL 14  Mcs14  Mammary carcinoma susceptibility QTL 13  Name updated 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
qtl_statistics_details Kruskal-Wallis nonparametric test and ANOVA were used to analyze multiplicity data 1559294