Mcs13 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Mcs13 (Mammary carcinoma susceptibility QTL 13) Rattus norvegicus

Symbol: Mcs13
Name: Mammary carcinoma susceptibility QTL 13
RGD ID: 1598814
Previously known as: Mcs5b
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor number   (CMO:0000343)    
LOD Score: Not Available
P Value: 1.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2563,190,890 - 69,927,503RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0568,395,096 - 71,941,113RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0572,838,045 - 76,105,732RGDRnor5.0
RGSC_v3.4565,553,185 - 73,080,336RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: WF.WKY-(D5Uwm66-D5Uwm67)/Uwm WF.WKY-(D5Uwm65-D5Uwm60)/Uwm 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mammary tumor number  IDA 1559294 RGD 

Experimental Condition
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
7,12-dimethyltetraphene (DMBA)  IDA 1559294 RGD 

Measurement Method
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
in vivo visual assessment  IDA 1559294 RGD 

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
WF.WKY-(D5Uwm65-D5Uwm60)/Uwm  IEA 1559294 RGD 
WF.WKY-(D5Uwm66-D5Uwm67)/Uwm  IEA 1559294 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mammary gland integrity trait  IDA 1559294 RGD 

Disease Annotations     Click to see Annotation Detail View

Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5. Samuelson DJ, etal., Cancer Res. 2005 Nov 1;65(21):9637-42.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2090Aldobaldolase, fructose-bisphosphate B56388904563902086Rat
2190Baatbile acid CoA:amino acid N-acyltransferase56385166863860641Rat
631344Abca1ATP binding cassette subfamily A member 156767826767801162Rat
621704Grin3aglutamate ionotropic receptor NMDA type subunit 3A56400684764206408Rat
621426Slc44a1solute carrier family 44 member 156806194168241912Rat
69232Ppp3r2protein phosphatase 3, regulatory subunit B, beta56402690364027898Rat
1305703Tmem38btransmembrane protein 38B56846030468496026Rat
1303116Plppr1phospholipid phosphatase related 156343745763725286Rat
1307218Pgap4post-GPI attachment to proteins GalNAc transferase 456393191663947004Rat
1333398Olr851olfactory receptor 85156751869167519650Rat
1333384Olr848olfactory receptor 84856740215767403110Rat
1333133Olr844olfactory receptor 84456730562067306573Rat
1332612Olr850olfactory receptor 85056745575167456701Rat
1333321Olr847olfactory receptor 84756727844467279397Rat
1333279Olr843-psolfactory receptor pseudogene 84356726430467264919Rat
1332764Olr841olfactory receptor 84156722777467228733Rat
1306510Zfp189zinc finger protein 18956387259663884348Rat
1305227Smc2structural maintenance of chromosomes 256680688266853478Rat
1308008Mrpl50mitochondrial ribosomal protein L5056386743763872591Rat
1309291RGD1309291similar to RIKEN cDNA 4930547C1056699808367000642Rat
1310087Fktnfukutin56833980368396412Rat
1359688Nipsnap3bnipsnap homolog 3B56763764467669698Rat
1311936Rnf20ring finger protein 2056397606364001754Rat
1334138Olr853olfactory receptor 85356758930667590244Rat
1562123Zfp462zinc finger protein 46256967008569810729Rat
1359532Acnat2acyl-coenzyme A amino acid N-acyltransferase 256375326963757521Rat
1333551Olr852olfactory receptor 85256755571867556668Rat
1332933Olr845olfactory receptor 84556733715267340910Rat
1334211Olr846-psolfactory receptor pseudogene 84656733739567338021Rat
1585791Cnppd1-ps1cyclin Pas1/PHO80 domain containing 1, pseudogene 156372743963729005Rat
1583730LOC500460similar to olfactory receptor Olr84156724174967242708Rat
1584718Acnat2-ps1acyl-coenzyme A amino acid N-acyltransferase 2, pseudogene56376466663786264Rat
1587377Hspa8-ps27heat shock protein family A (Hsp70) member 8, pseudogene 2756660632766608257Rat
1583223Nipsnap3anipsnap homolog 3A (C. elegans)56761399367625067Rat
1564956RGD1564956similar to calcium binding protein P2256857089468571875Rat
1564809Fsd1lfibronectin type III and SPRY domain containing 1-like56825887768334931Rat
1562799Cylc2cylicin 256555432065576251Rat
1594316Rps6-ps10ribosomal protein S6, pseudogene 1056668085366681691Rat
1586077Btbd10-ps2BTB domain containing 10, pseudogene 256651324066514662Rat
1584701Acnat1acyl-coenzyme A amino acid N-acyltransferase 156379665163801601Rat
1594562Crat-ps1carnitine O-acetyltransferase, pseudogene 156952910069531269Rat
1595137LOC685311similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)56863483968635405Rat
1596467Tal2TAL bHLH transcription factor 256841101268417569Rat
1597991Sod2-ps1superoxide dismutase 2, pseudogene 156625852666259065Rat
1598042Gemin8-ps9gem (nuclear organelle) associated protein 8, pseudogene 956573527265735956Rat
1597744Rps23-ps8ribosomal protein S23, pseudogene 856800625968006756Rat
2322103LOC100360453chromobox homolog 3-like56828055868281429Rat
2321090Gpx8-ps1glutathione peroxidase 8, pseudogene 156984410869844745Rat
2324538Ola1-ps1Obg-like ATPase 1, pseudogene 156660184566602611Rat
2324157Rpl18-ps2ribosomal protein L18, pseudogene 256937553669376103Rat
6487777LOC100912327olfactory receptor 13C3-like56737248967373466Rat
7525226Plet1-ps1placenta expressed transcript 1, pseudogene 156847472768477394Rat
7499527LOC102551410uncharacterized LOC10255141056802042068030171Rat
7555191LOC102551474uncharacterized LOC10255147456811484168145983Rat
9340681LOC103692353uncharacterized LOC10369235356784980867858913Rat
11415834LOC108350970uncharacterized LOC10835097056484877564970925Rat
41248950LOC120103343small nucleolar RNA SNORA1756865391268654044Rat
41253762LOC120103313small nucleolar RNA SNORA1756854841868548540Rat
41259190Rpl36a-ps12ribosomal protein L36A, pseudogene 1256795430567958398Rat
41361886LOC120102877uncharacterized LOC12010287756719190567195516Rat
41329014LOC120103196U6 spliceosomal RNA56712440067124500Rat
41212488LOC120103151uncharacterized LOC12010315156914468869153641Rat
41367081LOC120103256small nucleolar RNA SNORD113/SNORD114 family56369844663698522Rat
41122531LOC120102880uncharacterized LOC12010288056949405369506142Rat
41215818LOC120103303small nucleolar RNA SNORA1756943219369432324Rat
41217704LOC120103339small nucleolar RNA SNORA1756324864463248766Rat
41128100LOC120103150olfactory receptor 13C3-like56742361867424571Rat
41272998LOC120103341small nucleolar RNA SNORA1756602623666026348Rat
41377042LOC120103354U6atac minor spliceosomal RNA56760131267601439Rat
40972487NEWGENE_40940579transfer RNA leucine (anticodon AAG)56986995869870038Rat
40926645LOC120103314small nucleolar RNA SNORA1756688363866883766Rat
41002171NEWGENE_40934091transfer RNA alanine (anticodon AGC)56368361763683691Rat
40933017LOC120103152cytochrome c oxidase subunit 6B1-like56964624769646803Rat
41052311Eif2s1-ps1eukaryotic translation initiation factor 2 subunit alpha, pseudogene 156403946064051932Rat
41336381LOC120102879uncharacterized LOC12010287956802166368030631Rat
41303713LOC120103338small nucleolar RNA SNORA1756469761764697721Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33921D5Mit219456928513369285327Ratregion
34216D5Mgh614456898430768984447Ratregion
37440D5Rat8412956954029569540447Ratregion
37684D5Rat7620056558701265587212Ratregion
36482D5Rat1215256785677667856928Ratregion
38768D5Rat10014856617408066174226Ratregion
39150D5Rat10420056925722469257424Ratregion
39402D5Rat13924656856377068564008Ratregion
41250D5Rat14028556416853864168813Ratregion
41250D5Rat14028556416859964168813Ratregion
41314D5Rat14116156807141868071553Ratregion
43895D5Got618556776813267768317Ratregion
43896D5Got13810456635427166354375Ratregion
43897D5Got12325056928512869285378Ratregion
43899D5Got717956397254563972724Ratregion
69560D5Uwm1716756676865566768840Ratregion
625776D5Got916256503376365033927Ratregion
66643D5Mco1715456822800968228173Ratregion
1581996D5Uwm6527756319089063191167Ratregion
1582030D5Uwm6622056992728369927503Ratregion
1628964D5Got26618456558474265584926Ratregion
1634131D5Got23320056925718969257389Ratregion
5036619AU04861826756685612066856374Ratregion
5033971RH14080821156819439268194603Ratregion
5032123RH9445517456388906563889239Ratregion
5032181RH12625720156849445868494659Ratregion
5029423UniSTS:23812654556828077368281315Ratregion
5032797RH13533319756833910768339304Ratregion
5033713RH13984318256967164069671822Ratregion
5031187BF40774313556508763165087766Ratregion
5059450AW53089316956402697064027396Ratregion
5059766BE10319317956813956468139743Ratregion
5058294BF38697915956363410263634261Ratregion
5049844RH13371419156824165168241842Ratregion
5041110RH12866820856372757263727780Ratregion
5041110RH12866820856372757263727780Ratregion
5045872RH13142718356388373763883920Ratregion
5041920RH12913521356388907463889287Ratregion
5047518RH13237319656553104265531238Ratregion
5049748RH13365918856810336268103550Ratregion
5039348RH12765420256386795963868161Ratregion
5042036RH12920215256388908063889232Ratregion
5042664RH129571056839598968396195Ratregion
5041108RH12866720756766938767669594Ratregion
5075392RH13856712256806282068062942Ratregion
5077892RH14002018156839331268393493Ratregion
5073098RH13723621256849422968494441Ratregion
5072946RH13714520856386865363868861Ratregion
5071814RH13530020556767933067679535Ratregion
5073912RH13771024656814698668147232Ratregion
5074102RH13782215356393196763932120Ratregion
5074160RH13785619556968438669684581Ratregion
5062164BE11285821156882895068829161Ratregion
5062700BF40388321256852725768527469Ratregion
5065928BE11617616556849325768493422Ratregion
5061976BF39703319156399519963995507Ratregion
5060776BF38911915956975430369754462Ratregion
5064292AW52991615456393812663938280Ratregion
5064470BF39928715756367816863678325Ratregion
5063282BI30163820356319848763198688Ratregion
5084230AA84882920856767853367678741Ratregion
5086042BE10377819056833001168330201Ratregion
5089807AU04937529356652837766528670Ratregion
5087484PMC207565P114156780109567801236Ratregion
5087873Fin1613756685302466853161Ratregion
5083729AI10538221656833188768332103Ratregion
5085028AI00898720756767986367680070Ratregion
5090299AU04966822456758368467583908Ratregion
5084832AI17218917756849559968495779Ratregion
5083487BF39148914656800775968007905Ratregion
5085958AI13709622056819073868190956Ratregion
5503813CDW92_935072456819137468192098Ratregion
5504222RH7997520756819085068191057Ratregion
5501434Sod224156625852166258762Ratregion
5501470D9S187E7156973380869733879Ratregion
5501838MARC_15327-15328:1017321397:179856399472063995518Ratregion
Position Markers

Flank 1: (D5Uwm65)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2563,190,890 - 63,191,167 (-)MAPPER
Rnor_6.0568,395,096 - 68,395,372NCBI
Rnor_5.0572,838,045 - 72,838,321UniSTS
RGSC_v3.4565,553,185 - 65,553,461UniSTS
Celera564,405,381 - 64,405,657UniSTS
Cytogenetic Map5 RGD
Flank 2: (D5Uwm66)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2569,927,283 - 69,927,503 (+)MAPPER
Rnor_6.0571,940,894 - 71,941,113NCBI
Rnor_5.0576,105,513 - 76,105,732UniSTS
RGSC_v3.4573,080,117 - 73,080,336UniSTS
Celera568,790,675 - 68,790,894UniSTS
Cytogenetic Map5 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598814Mcs13Mammary carcinoma susceptibility QTL 130.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)56319089069927503Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general WKY alleles associated with increased mammary tumor susceptibility in this QTL region 1559294
qtl_statistics_details Kruskal-Wallis nonparametric test and ANOVA were used to analyze multiplicity data 1559294