Insul6 QTL Report (Rattus norvegicus)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

QTL Registration

General

QTL: Insul6 (Insulin level QTL 6) Rattus norvegicus
Symbol:	Insul6
Name:	Insulin level QTL 6
RGD ID:	1582213
Previously known as:	Insulin (dex, ln)
Trait:	blood insulin amount (VT:0001560)
Measurement Type:	calculated serum insulin level (CMO:0000359)
LOD Score:	3.7
P Value:	9.0E-4
Variance:	13.0
Position	No map positions available.
Cross Type:	intercross
Strains Crossed:	PD/Cub BN/Cub

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hyperinsulinism (TAS)

Metabolic Syndrome (IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased circulating insulin level (IAGP)

Experimental Data Annotations Click to see Annotation Detail View

Clinical Measurement

calculated serum insulin level (IDA)

Experimental Condition

controlled sucrose content diet (IDA)

dexamethasone (IDA)

fasting (IDA)

Measurement Method

oral glucose tolerance test (IDA)

Vertebrate Trait

blood insulin amount (IDA)

Rat Strain

BN/Cub (IEA)

PD/Cub (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Dynamic genetic architecture of metabolic syndrome attributes in the rat.	Seda O, etal., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22.

Related QTLs

Related QTL	Description	Reference
Sffal1	interacts with	RGD:1580752

Region

Markers in Region

The following Markers overlap with this region.

RGD ID

Symbol

Expected Size

Chr

Start

Stop

Species

Match

Position Markers

Flank 1: (D3Rat213)

Rat Assembly	Chr	Position (strand)	Source
SHRSP x BN Map	3	67.6099	UniSTS
SHRSP x BN Map	3	67.6099	RGD

Peak: (D3Rat143)

Rat Assembly	Chr	Position (strand)	Source
RH 3.4 Map	3	1485.5	RGD
RH 3.4 Map	3	1485.5	UniSTS
SHRSP x BN Map	3	78.8599	UniSTS
SHRSP x BN Map	3	78.8599	RGD

Flank 2: (D3Rat143)

Rat Assembly	Chr	Position (strand)	Source
RH 3.4 Map	3	1485.5	RGD
RH 3.4 Map	3	1485.5	UniSTS
SHRSP x BN Map	3	78.8599	UniSTS
SHRSP x BN Map	3	78.8599	RGD

Additional Information

RGD Curation Notes

Note Type	Note	Reference
qtl_cross_type	intercross
qtl_general	dexamethasone (DEX) was given in drinking water (0.026mg/ml) for 3 days and insulin level was determined using a RIA kit	1580752
qtl_statistics_details	specific pairs of variables were compared by one or two way ANOVA with post hoc Tukey's honest significance difference test; linkage analysis was done on logarithm-transformed values	1580752

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description:

Send us a Message

QTL: Insul6 (Insulin level QTL 6) Rattus norvegicus

Mammalian Phenotype