Eae21 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Eae21 (Experimental allergic encephalomyelitis QTL 21) Rattus norvegicus

Symbol: Eae21
Name: Experimental allergic encephalomyelitis QTL 21
RGD ID: 1581566
Trait: body mass   (VT:0001259)    
Measurement Type: maximum body weight loss to initial body weight ratio   (CMO:0001400)    
LOD Score: 6.2
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,680,158 - 158,841,762RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.04157,399,119 - 158,564,471RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04224,422,165 - 225,566,369RGDRnor5.0
RGSC_v3.44162,206,044 - 162,362,144RGDRGSC3.4
RGSC_v3.14162,450,980 - 162,607,080RGD
Cross Type: Not Available
Strains Crossed: DA PVG.1AV1 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
maximum body weight loss to initial body weight ratio  IDA 1547849 RGD 

Experimental Condition
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Freund's incomplete adjuvant  IDA 1547849 RGD 
myelin oligodendrocyte glycoprotein  IDA 1547849 RGD 

Measurement Method
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
body weighing method  IDA 1547849 RGD 

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DA  IEA 1547849 RGD 
PVG.1AV1  IEA 1547849 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
body mass  IDA 1547849 RGD 

Disease Annotations     Click to see Annotation Detail View

Experimental Data Annotations     Click to see Annotation Detail View

Measurement Method

Vertebrate Trait
body mass  (IDA)

Rat Strain
DA  (IEA)
PVG.1AV1  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Resolution of a 16.8-Mb autoimmunity-regulating rat chromosome 4 region into multiple encephalomyelitis quantitative trait loci and evidence for epistasis. Jagodic M, etal., J Immunol 2005 Jan 15;174(2):918-24.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2306Cd4Cd4 molecule4157668878157695366Rat
1302990Lag3lymphocyte activating 34157712665157722229Rat
621529Ptmsparathymosin4157722384157726575Rat
1306294Mlf2myeloid leukemia factor 24157739651157744325Rat
1310070Cops7aCOP9 signalosome subunit 7A4157766626157792632Rat
41200147LOC120102584U6 spliceosomal RNA4157772787157772892Rat
40933824LOC120102387uncharacterized LOC1201023874157788553157793531Rat
1304952PianpPILR alpha associated neural protein4157796425157804842Rat
708346Zfp384zinc finger protein 3844157810263157840052Rat
7507389LOC102554095uncharacterized LOC1025540954157831204157851015Rat
1309407Ing4inhibitor of growth family, member 44157841882157850519Rat
1564880Acrbpacrosin binding protein4157851149157864211Rat
1562580Lpar5lysophosphatidic acid receptor 54157870493157883979Rat
40984833Trnap-agg37transfer RNA proline (anticodon AGG) 374157888872157888946Rat
620064Chd4chromodomain helicase DNA binding protein 44157898503157931632Rat
41371508LOC120102389uncharacterized LOC1201023894157913815157921519Rat
40942840Scarna11small Cajal body-specific RNA 114157923016157923151Rat
1304616Nop2NOP2 nucleolar protein4157932731157944462Rat
1308257Iffo1intermediate filament family orphan 14157945075157962302Rat
2661Gapdhglyceraldehyde-3-phosphate dehydrogenase4157962312157967158Rat
1562596Ncapd2non-SMC condensin I complex, subunit D24157968814157992314Rat
41366642Scarna10small Cajal body-specific RNA 104157986558157986885Rat
1306686Mrpl51mitochondrial ribosomal protein L514157991756157994715Rat
3948Vamp1vesicle-associated membrane protein 14158012634158019350Rat
1307893TapbplTAP binding protein-like4158021454158028905Rat
41257034LOC120102390uncharacterized LOC1201023904158028943158032695Rat
1560499Cd27CD27 molecule4158030700158035862Rat
41018919LOC120102626small nucleolar RNA SNORA704158053924158054052Rat
7708239LOC102555545uncharacterized LOC1025555454158058337158075209Rat
1565719Tuba3atubulin, alpha 3A4158075083158083972Rat
1309448Ltbrlymphotoxin beta receptor4158108884158115339Rat
3639Scnn1asodium channel epithelial 1 subunit alpha4158122962158146184Rat
621237Tnfrsf1aTNF receptor superfamily member 1A4158150815158163592Rat
2318544Plekhg6pleckstrin homology and RhoGEF domain containing G64158163443158182628Rat
41268541Rnu6-212RNA, U6 small nuclear 2124158206300158206401Rat
2318Cd9CD9 molecule4158256328158289136Rat
621759Vwfvon Willebrand factor4158360152158491539Rat
1591606Ano2anoctamin 24158514200158855639Rat
41030033LOC120102587U6 spliceosomal RNA4158700406158700512Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36926D4Rat661234157704599157704722Ratregion
35879D4Rat671404157710145157710285Ratregion
40660D4Rat2031484158112655158112799Ratregion
60414D4Got1271604157778202157778362Ratregion
60416D4Got1291834158075992158076173Ratregion
60418D4Got1312134158260855158261065Ratregion
60419D4Got1322524158841508158841762Ratregion
629592D4Hmgc21964158133085158133293Ratregion
1630596D4Wox361764158447303158447479Ratregion
5036400Ltbr1664158109432158109598Ratregion
5036535Vamp12264158019065158019291Ratregion
5036537Vwf2024158447823158448025Ratregion
5035725RH648271394157931463157931602Ratregion
5032501D6Ertd380e1954157931232157931427Ratregion
5027129WI-80133334157766990157767323Ratregion
5032861RH1367571204157855052157855172Ratregion
5025022BE2926151134158019003158019116Ratregion
5025250RH1275931974157850174157850371Ratregion
5028271D6Mit2171634158120313158120476Ratregion
5051415AI5287791084158075128158075236Ratregion
5051633BB16399304157839470157839584Ratregion
5051745RH946341604158017434158017594Ratregion
5052077RH948261134158163236158163349Ratregion
5057406AA9637931824157931325157931507Ratregion
5054987RH1435402204157929005157929225Ratregion
5058810BI2780542134157722393157722606Ratregion
5052795RH1422781744157804459157804633Ratregion
5051737RH94629694158145273158145342Ratregion
5041596RH1289481584157744053157744211Ratregion
5041780RH1290541704157995206157995376Ratregion
5044706RH1307571904158213865158214054Ratregion
5045216RH1310511884157721378157721566Ratregion
5045644RH1312962054158108974158109179Ratregion
5048220RH1327771934158491246158491439Ratregion
5039444RH1277092074157767314157767521Ratregion
5042842RH1296771804157968931157969114Ratregion
5076360RH1391301294158258995158259124Ratregion
5077532RH1398101964157992767157993468Ratregion
5076714RH1393362324158741748158741980Ratregion
5077988RH1400772034157839189157839392Ratregion
5079900RH1412672094157944179157944388Ratregion
5079900RH1412672094157944179157944388Ratregion
5078244RH1402271944157961933157962127Ratregion
5078720RH1405121584157994729157994887Ratregion
5066970AU0480421874158112657158112846Ratregion
5068708AU046982924157854700157855312Ratregion
5068868AU0468761364158694785158694918Ratregion
5063604BE1078321964157977269157977465Ratregion
5063834BE1200141534158599853158600006Ratregion
5061420BE1051331574157993998157994155Ratregion
5089505AU0491952554158822360158822615Ratregion
5081312RH1420871984158163215158163413Ratregion
5499921UniSTS:2355561044157970683157970787Ratregion
5500657RH1365192054157743973157744178Ratregion
5503698MARC_34374-34375:1062687298:14574157931029157931486Ratregion
5502643RH1261382214157744080157744301Ratregion
Position Markers

Flank 1: (D14Rat113)
Rat AssemblyChrPosition (strand)Source
RH 2.0 Map14174.1RGD
SHRSP x BN Map146.9RGD
Peak: (D4Got131)
Rat AssemblyChrPosition (strand)Source
mRatBN7.24158,260,855 - 158,261,065 (+)MAPPER
Rnor_6.04157,981,691 - 157,981,900NCBI
Rnor_5.04224,994,163 - 224,994,372UniSTS
RGSC_v3.44162,283,989 - 162,284,199RGD
RGSC_v3.44162,283,990 - 162,284,199UniSTS
RGSC_v3.14162,528,926 - 162,529,135RGD
Celera4146,995,674 - 146,995,881UniSTS
RH 3.4 Map41005.5RGD
RH 3.4 Map41005.5UniSTS
Cytogenetic Map4q42UniSTS
Flank 2: (D4Got132)
Rat AssemblyChrPosition (strand)Source
mRatBN7.24158,841,508 - 158,841,762 (+)MAPPER
Rnor_6.04158,564,220 - 158,564,471NCBI
Rnor_5.04225,566,118 - 225,566,369UniSTS
RGSC_v3.44162,361,892 - 162,362,144RGD
RGSC_v3.44162,361,893 - 162,362,144UniSTS
RGSC_v3.14162,606,829 - 162,607,080RGD
Celera4147,567,471 - 147,567,722UniSTS
RH 3.4 Map41002.1RGD
RH 3.4 Map41002.1UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4157680158158841762Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_statistics_details QTL also linked to severity of disease and duration of disease 1547849