Eae18 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Eae18 (Experimental allergic encephalomyelitis QTL 18) Rattus norvegicus

Symbol: Eae18
Name: Experimental allergic encephalomyelitis QTL 18
RGD ID: 1581559
Trait: nervous system integrity trait   (VT:0010566)    
Measurement Type: experimental autoimmune encephalomyelitis severity score   (CMO:0001419)    
LOD Score: Not Available
P Value: 2.0E-5
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210107,057,622 - 107,211,142RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01067,988,218 - 110,992,091RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01067,642,304 - 110,568,486RGDRnor5.0
RGSC_v3.41023,843,272 - 68,843,272RGDRGSC3.4
RGSC_v3.11023,856,895 - 68,856,895RGD
Cross Type: Not Available
Strains Crossed: DA.ACI-(D10Rat2-D10Rat29)/Kini 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
experimental autoimmune encephalomyelitis severity score  IDA 1302800 RGD 

Experimental Condition
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myelin oligodendrocyte glycoprotein  IDA 1302800 RGD 

Measurement Method
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
in vivo visual assessment  IDA 1302800 RGD 

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
DA.ACI-(D10Rat2-D10Rat29)/Kini  IEA 1302800 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nervous system integrity trait  IDA 1302800 RGD 

Disease Annotations     Click to see Annotation Detail View

Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Jagodic M, etal., Immunogenetics 2001 Jul;53(5):410-5.
2. Common genetic determinants of uveitis shared with other autoimmune disorders. Mattapallil MJ, etal., J Immunol. 2008 May 15;180(10):6751-9.
3. Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice. Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.
Related QTLs

Related QTL Description Reference
Eau9 maps to same region RGD:2296064
Eae23 sub_region RGD:2293859


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1584945Rpl23a-ps13ribosomal protein L23a, pseudogene 1310107077994107081835Rat
1590039Ptchd3patched domain containing 310107097590107108563Rat
7527378LOC102551980uncharacterized LOC10255198010107141071107166722Rat
7594162LOC102551882zinc finger protein 120-like10107115705107136643Rat
7686500LOC102550944zinc finger protein 709-like10107173064107184585Rat
41284199LOC120095434small nucleolar RNA SNORA4810107103489107103632Rat
41179444LOC120095349U6 spliceosomal RNA10107167697107167803Rat
40964877Capzb-ps1capping actin protein of muscle Z-line subunit beta, pseudogene 110107084132107088667Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
35254D10Rat217810107057622107057807Ratregion
39188D10Rat9721110107148227107148444Ratregion
Position Markers

Flank 1: (D10Rat2)
Rat AssemblyChrPosition (strand)Source
mRatBN7.210107,057,622 - 107,057,807 (+)MAPPER
Rnor_6.010110,992,091 - 110,992,275NCBI
Rnor_5.010110,568,486 - 110,568,670UniSTS
Celera10105,592,664 - 105,592,836UniSTS
SHRSP x BN Map1093.86RGD
SHRSP x BN Map1093.86UniSTS
Flank 2: (D10Rat29)
Rat AssemblyChrPosition (strand)Source
Rnor_6.01067,988,035 - 67,988,218NCBI
Rnor_5.01067,642,121 - 67,642,304UniSTS
RGSC_v3.41068,842,878 - 68,843,272RGD
RGSC_v3.41068,842,891 - 68,843,074UniSTS
RGSC_v3.11068,856,501 - 68,856,895RGD
Celera1064,569,293 - 64,569,476UniSTS
RH 2.0 Map10657.7RGD
SHRSP x BN Map1046.5699RGD
FHH x ACI Map1053.73RGD
Cytogenetic Map10q26UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)10107057622107211142Rat


Additional Information

RGD Curation Notes
Note Type Note Reference