Cm59 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Cm59 (Cardiac mass QTL 59) Rattus norvegicus

Symbol: Cm59
Name: Cardiac mass QTL 59
RGD ID: 1581519
Previously known as: Lvm11
Trait: heart left ventricle mass   (VT:0007031)    
Measurement Type: heart left ventricle weight to body weight ratio   (CMO:0000530)    
LOD Score: 2.8
P Value: 0.05
Variance: 3.0
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21588,853,470 - 95,840,528RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01596,777,066 - 104,003,672RGD_MAPPER_PIPELINERnor6.0
Rnor_5.015100,267,081 - 107,428,111RGDRnor5.0
RGSC_v3.41596,375,862 - 103,677,388RGDRGSC3.4
RGSC_v3.11596,391,642 - 103,693,168RGD
Cross Type: Not Available
Strains Crossed: WKY/Cfd WKHA/Cfd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
heart left ventricle weight to body weight ratio  IDA 1578726 RGD 

Experimental Condition
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
control condition  IDA 1578726 RGD 

Measurement Method
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
post excision weight measurement  IDA 1578726 RGD 

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
WKHA/Cfd  IEA 1578726 RGD 
WKY/Cfd  IEA 1578726 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
heart left ventricle mass  IDA 1578726 RGD 

Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
WKHA/Cfd  (IEA)
WKY/Cfd  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Distinct QTLs are linked to cardiac left ventricular mass in a sex-specific manner in a normotensive inbred rat inter-cross. Llamas B, etal., Mamm Genome. 2005 Sep;16(9):700-11. Epub 2005 Oct 20.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
620266Abcc4ATP binding cassette subfamily C member 4159554118695774898Rat
1304724Sox21SRY-box transcription factor 21159529227295295316Rat
1306544TgdsTDP-glucose 4,6-dehydratase159517460795195577Rat
1359193Gpr180G protein-coupled receptor 180159519578295224955Rat
1310957Slitrk5SLIT and NTRK-like family, member 5158884812388858809Rat
1308835Gpc5glypican 5159220727593644054Rat
1564975Dctdopachrome tautomerase159506200695100863Rat
1592123Rps11-ps11ribosomal protein S11, pseudogene 11159145907091459609Rat
1592124Nsa2-ps8NSA2 ribosome biogenesis factor, pseudogene 8159091718590918020Rat
1592125C16h19orf44-ps1similar to human chromosome 19 open reading frame 44, pseudogene 1158976300589764127Rat
1593308Gpc6glypican 6159403021895027883Rat
2316379Vom1r-ps104vomeronasal 1 receptor pseudogene 104159064415390645034Rat
2325390Mir92a1microRNA 92a-1159218133692181413Rat
2325396Mir18amicroRNA 18a159218076592180860Rat
2325401Mir20amicroRNA 20a159218108492181168Rat
2325433Mir19b1microRNA 19b-1159218121492181300Rat
2325462Mir19amicroRNA 19a159218091292180993Rat
2325600Mir17microRNA 17159218062992180712Rat
6488688LOC10091213260S ribosomal protein L10-like159341778893418406Rat
7517571LOC10254836940S ribosomal protein S16-like159225976392260218Rat
7613297LOC102547440uncharacterized LOC102547440159096273691056107Rat
7654866LOC102549101uncharacterized LOC102549101159535610895360987Rat
7644006LOC102548462uncharacterized LOC102548462159221026192241147Rat
7620398LOC102548872uncharacterized LOC102548872159511475295122461Rat
7551051LOC102547827uncharacterized LOC102547827159124609691274378Rat
7735776LOC102548945uncharacterized LOC102548945159515310795163012Rat
7705185Ipo5-ps2importin 5, pseudogene 2159469698594698791Rat
7684851LOC102550064uncharacterized LOC102550064159064649290670738Rat
7716610LOC102550532uncharacterized LOC102550532159082435890826589Rat
7717526LOC102550250uncharacterized LOC102550250159072108890793587Rat
9095740LOC103693790uncharacterized LOC103693790159539505695417585Rat
9231101Tmem11-ps1transmembrane protein 11, pseudogene 1159444922194450151Rat
9449268LOC103693782uncharacterized LOC103693782159453665594540278Rat
11467873LOC108353050protein transport protein Sec61 subunit gamma pseudogene159016860990169004Rat
11394812LOC10835302940S ribosomal protein S6 pseudogene159448741794488169Rat
11501014LOC108352972uncharacterized LOC108352972159117279191220830Rat
11510082LOC10835301240S ribosomal protein S17 pseudogene159175115591760651Rat
11513546LOC108352971uncharacterized LOC108352971158930528289472145Rat
11492158Trnaf-gaa5transfer RNA phenylalanine (anticodon GAA) 5159515332395153395Rat
41324489Pcbp2-ps2poly(rC) binding protein 2, pseudogene 2159118261391186823Rat
41253514LOC120097178uncharacterized LOC120097178159453023894533381Rat
41363845LOC120097318U6 spliceosomal RNA159564706895647171Rat
41192109LOC120097081uncharacterized LOC120097081159566944695671421Rat
41229299LOC120097209small nucleolar RNA SNORA70159341777793417911Rat
41401429Trnaa-agc65transfer RNA alanine (anticodon AGC) 65158973361389733687Rat
41007823LOC120097177uncharacterized LOC120097177159410394094117928Rat
40937839LOC120097261small nucleolar RNA SNORA17159536277595362881Rat
41010480LOC120097305U6 spliceosomal RNA159119039091190496Rat
41338783LOC120097306U6 spliceosomal RNA159350534093505446Rat
41059821LOC120097082uncharacterized LOC120097082159584002795844074Rat
41301829LOC120097284U2 spliceosomal RNA159003149590031677Rat
41039265LOC120097078uncharacterized LOC120097078159105624391080155Rat
41238556LOC120097315U6 spliceosomal RNA158919629889196401Rat
41046097LOC120097080uncharacterized LOC120097080159200549392016267Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33820D15Mit6194159136585891366070Ratregion
34160D15Mgh5100159501812095018228Ratregion
34162D15Mgh6211159584030895840528Ratregion
36149D15Rat26165159234692692347073Ratregion
35497D15Rat25154159300474493004898Ratregion
37014D15Rat24137159444176894441898Ratregion
40490D15Rat127259159513767995137927Ratregion
40106D15Rat102153159008859190088744Ratregion
39324D15Rat51245159438973094389966Ratregion
39570D15Rat104241159416388094164117Ratregion
43059D15Rat155238159303357493033814Ratregion
43060D15Rat156229159303357493033803Ratregion
44552D9Wox21136158887494088874993Ratregion
43400D15Got96132158924782489247958Ratregion
45287D15Got8679158992367789923756Ratregion
45290D15Got85274159283353592833809Ratregion
45291D15Got90244159431851394318757Ratregion
1578852D10Chm22221159446336194463582Ratregion
5029169RH143776149159570976095709909Ratregion
5026766RH133447207159522471695224923Ratregion
5056029RH144142110159520180595201915Ratregion
5056955RH144677174159434742994347603Ratregion
5056563RH144451101158885947688859577Ratregion
5059836BF388001180159324398293244162Ratregion
5045686RH131320187159364364493643831Ratregion
5046522RH131802211159506204595062256Ratregion
5040304RH128206205159502742095027625Ratregion
5080000RH141325188159502410995024297Ratregion
5080358RH141533210159554240395542613Ratregion
5071464RH135097219159502435395024572Ratregion
5064986BE108844150159527037695270526Ratregion
5066656AU048228294159279004592790330Ratregion
5067264AU047861292159574008095740374Ratregion
5062186BF397529229159522321295223441Ratregion
5064392BF399195182159482382594824007Ratregion
5060616BI286235205159577547495775679Ratregion
5064548BF399357153159511381395113966Ratregion
5064824BF405158124158885593588856059Ratregion
5061566BF40204998159296904892969146Ratregion
5081887BE118647167159434973394349900Ratregion
5082039BF415743115159224162192241736Ratregion
5082093BF409444103159577901995779122Ratregion
5086823BE107383169159218337192183540Ratregion
5506171AFM350VD1438159253776492538202Ratregion
5502780DCT515159508864195089156Ratregion
5502782GPC6115159403094294031057Ratregion
5501476D5S6800159361356293614912Ratregion
5501476D5S6800159361392593614912Ratregion
Position Markers

Flank 1: (D15Mgh6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21595,840,308 - 95,840,528 (+)MAPPER
Rnor_6.015104,003,455 - 104,003,672NCBI
Rnor_5.015107,427,894 - 107,428,111UniSTS
RGSC_v3.415103,677,171 - 103,677,388UniSTS
RGSC_v3.415103,677,170 - 103,677,388RGD
RGSC_v3.115103,692,950 - 103,693,168RGD
Celera1594,690,276 - 94,690,493UniSTS
RH 3.4 Map15657.0UniSTS
RH 3.4 Map15657.0RGD
RH 2.0 Map15569.0RGD
Cytogenetic Map15 RGD
Peak: (D15Rat26)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21592,346,926 - 92,347,073 (+)MAPPER
Rnor_6.015100,390,296 - 100,390,442NCBI
Rnor_5.015103,847,523 - 103,847,669UniSTS
RGSC_v3.415100,026,553 - 100,026,699UniSTS
RGSC_v3.415100,026,552 - 100,026,699RGD
RGSC_v3.115100,042,332 - 100,042,479RGD
Celera1591,210,749 - 91,210,895UniSTS
RH 3.4 Map15610.4RGD
RH 3.4 Map15610.4UniSTS
RH 2.0 Map15495.0RGD
SHRSP x BN Map1558.4498RGD
Cytogenetic Map15q24UniSTS
Flank 2: (D15Rat41)
Rat AssemblyChrPosition (strand)Source
SHRSP x BN Map1534.6299RGD
SHRSP x BN Map1534.6299UniSTS
FHH x ACI Map1547.47RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
1581555Eae19Experimental allergic encephalomyelitis QTL 194.7nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)157630609990088744Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat
1581519Cm59Cardiac mass QTL 592.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)158885347095840528Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_statistics_details MapManager QTX used for linkage analysis; analysis was for female rats only 1578726