Bp270 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bp270 (Blood pressure QTL 270) Rattus norvegicus

Symbol: Bp270
Name: Blood pressure QTL 270
RGD ID: 1579916
Previously known as: C2QTL4; C2QTL4L
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: mean arterial blood pressure   (CMO:0000009)    
LOD Score: Not Available
P Value: 0.003
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2256,531,912 - 59,324,719RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0256,736,401 - 60,325,686RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0276,472,547 - 84,554,681RGDRnor5.0
RGSC_v3.4256,722,060 - 59,701,221RGDRGSC3.4
RGSC_v3.1214,629,454 - 59,629,454RGD
Cross Type: Not Available
Strains Crossed: SS.LEW-(D2Rat199-D2Rat143)/Ayd SS.LEW-(D2Rat18-D2Chm277)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
2. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.
3. Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on Chromosome 2. Eliopoulos V, etal., Physiol Genomics 2005 Apr 12;.
Related QTLs

Related QTL Description Reference
Bp310 interacts with RGD:7421500


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1594500Rps9-ps4ribosomal protein S9, pseudogene 425658228856582972Rat
11356949LOC10835015540S ribosomal protein S6 pseudogene25664481656655429Rat
1594499Snw1-ps1SNW domain containing 1, pseudogene 125674032056741899Rat
2677Gdnfglial cell derived neurotrophic factor25689402256919935Rat
41213708LOC120101118U2 spliceosomal RNA25692982556930018Rat
1309487Wdr70WD repeat domain 7025695134557191244Rat
41041387Pld6-ps1phospholipase D family, member 6, pseudogene 125702950057031550Rat
621199Nup155nucleoporin 15525720131057252918Rat
40941042LOC120100734uncharacterized LOC12010073425722934357230048Rat
1310081Cplane1ciliogenesis and planar polarity effector complex subunit 125726919557369580Rat
6495770Hnrnpa1-ps29heterogeneous nuclear ribonucleoprotein A1, pseudogene 2925729338457298637Rat
1594378Nono-ps8non-POU domain containing, octamer-binding, pseudogene 825738143957382974Rat
40994045Rpl9-ps4ribosomal protein L9, pseudogene 425739033357399288Rat
1306393NipblNIPBL, cohesin loading factor25739944357586770Rat
11388086Rpl23-ps4ribosomal protein L23,pseudogene 425753907957542026Rat
2324086Rps12-ps3ribosomal protein S12, pseudogene25761507957615691Rat
2323951Hmgn2l2high mobility group nucleosomal binding domain 2 like 225761869057618983Rat
9200405LOC103691481uncharacterized LOC10369148125770176757704913Rat
3698Slc1a3solute carrier family 1 member 325775549557830605Rat
11382166LOC108349962uncharacterized LOC10834996225783544257840143Rat
1307559Ranbp3lRAN binding protein 3-like25805788758113158Rat
1583619Rps2-ps9ribosomal protein S2, pseudogene 925810144858102404Rat
41207236LOC120100736uncharacterized LOC12010073625810997758118986Rat
1306809Nadk2NAD kinase 2, mitochondrial25811767458159815Rat
1562456Skp2S-phase kinase associated protein 225816122658189293Rat
1563920Lmbrd2LMBR1 domain containing 225818955858251565Rat
1596810Ugt3a2-ps2UDP glycosyltransferase 3 family, polypeptide A2, pseudogene 225831491258327069Rat
1564365Ugt3a1UDP glycosyltransferase family 3 member A125832705858350186Rat
41241035Ugt3a2-ps1UDP glycosyltransferase 3 family, polypeptide A2, pseudogene 125838571458389680Rat
1308776Capslcalcyphosine-like25839499558425527Rat
1309776Il7rinterleukin 7 receptor25845239358477757Rat
620450Spef2sperm flagellar 225851248958694718Rat
41111255LOC120100737E3 SUMO-protein ligase KIAA1586-like25853208058540473Rat
41397082LOC120100738uncharacterized LOC12010073825862629358669887Rat
41127911Nono-ps5non-POU domain containing, octamer-binding, pseudogene 525875832858760040Rat
41178470LOC120100559uncharacterized LOC12010055925877866258796834Rat
3407Prlrprolactin receptor25913414759324719Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
11155D2Wox1418225932445459324636Ratregion
11156D2Mit2431025932437759324691Ratregion
35272D2Rat1914025760561257605741Ratregion
42119D2Arb633525932430759324662Ratregion
42121D2Arb715025666087956661032Ratregion
42573D2Rat38523325752299657523239Ratregion
66537D12Uia227025917270459172974Ratregion
67257D2Arb828025842920558429485Ratregion
1632178D2Got31222425785740057857624Ratregion
1578947D2Chm28022125917985359180074Ratregion
1579094D2Chm27722725653191256532139Ratregion
1628202D2Wox2913625875755058757686Ratregion
1629260D2Got38426525703039757030664Ratregion
1639805D2Got31329525710294157103236Ratregion
1640402D2Got42519925658592756586126Ratregion
1640402D2Got42519925658592756586126Ratregion
1636843D2Got30823725714186357142100Ratregion
1634123D2Got31019525750176157501956Ratregion
7192180Prlr12025930626159306381Ratregion
5029953BF40012520025866911958669319Ratregion
5027483AI5042999225780811557808207Ratregion
5030659BI30169816025717937057179530Ratregion
5054867RH14347117625731049257310668Ratregion
5054873RH14347421825778815057788368Ratregion
5054203RH14308926525730172357301988Ratregion
5055103RH14360726325816172358161986Ratregion
5058794BI27801919625717781057178006Ratregion
5059950BF38820419325808475558084948Ratregion
5053335RH14258911825725577757255895Ratregion
5050686RH13420019025718533957186096Ratregion
5051553AW12520510525841458658414691Ratregion
5054695RH14337217225739977757399949Ratregion
5041370RH12881818425816131258161496Ratregion
5039610RH12780418025825119158251371Ratregion
5076828RH13940212825725379457253922Ratregion
5077058RH13953519125775567757755868Ratregion
5074990RH13833515525770179157701946Ratregion
5076066RH13895921425725614157256355Ratregion
5075092RH13839312525736932257369447Ratregion
5075578RH13867512125815914658159267Ratregion
5078486RH14037013125775574457755875Ratregion
5069026AU04677315225659109856591250Ratregion
5069026AU04677315225659109856591250Ratregion
5069770AU02885912625885980358859929Ratregion
5061080AW53213219025756959557569785Ratregion
5066460AU04834330025710293657103236Ratregion
5087219AW52416516325725469957254862Ratregion
5088060Prlr13525929089759291032Ratregion
5090727AU04992722825776599157766219Ratregion
5081673BE11797221525750218957502404Ratregion
5503458GDNF_315047625691674556917221Ratregion
5504857ha260088825878094258781904Ratregion
5501988MARC_21845-21846:1025102921:176525748300657483771Ratregion
5500362GDB:33540916925776772057767887Ratregion
5501460D9S5527025797253357972803Ratregion
5501974MARC_21512-21513:1032982746:3101325724384857244861Ratregion
Position Markers

Flank 1: (D2Chm277)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2256,531,912 - 56,532,139 (+)MAPPER
Rnor_6.0256,736,401 - 56,736,627NCBI
Rnor_5.0276,472,547 - 76,472,773UniSTS
RGSC_v3.4256,722,060 - 56,722,286UniSTS
Celera252,150,912 - 52,151,140UniSTS
Cytogenetic Map2 RGD
Flank 2: (Prlr)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,134,147 - 59,324,719 (+)NCBI
mRatBN7.2 Ensembl259,134,588 - 59,324,718 (+)Ensembl
UTH_Rnor_SHR_Utx266,245,300 - 66,425,431 (+)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.0264,366,825 - 64,546,955 (+)NCBI
UTH_Rnor_WKY_Bbb_1.0259,368,154 - 59,548,295 (+)NCBI
Rnor_6.0260,131,410 - 60,325,686 (+)NCBI
Rnor_6.0 Ensembl260,131,776 - 60,325,692 (+)Ensembl
Rnor_5.0284,360,850 - 84,554,681 (-)NCBI
RGSC_v3.4259,507,966 - 59,701,221 (+)NCBI
RGSC_v3.1259,485,049 - 59,629,454 (+)NCBI
Celera259,347,111 - 59,534,658 (-)NCBI
Cytogenetic Map2q16NCBI


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)25653191259324719Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_gene Agtr1b excluded as a candidate gene in this study 1358142
qtl_general paradoxically, it is the LEW allele (normotensive strain) that is associated with increased blood pressure 1358142
qtl_map QTL flanking region defined by comparative mapping of congenic strains retaining or lacking the QTL; strains SS.LEW-(D2Rat199-D2Rat143)/Ayd and SS.LEW-(D2Rat199-D2Mco17)/Ayd retain the blood pressure QTL while strains SS.LEW-(D2Rat18-D2Chm277)/Ayd and SS.LEW-(Prlr-D2Rat143)/Ayd do not confer blood pressure effects 1358142
qtl_statistics_details ANOVA with Dunnett's correction was used to compare mean arterial pressures between Dahl salt sensitive rats and the congenic strains 1358142