Stl26 QTL Report (Rattus norvegicus)

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QTL Registration

General

QTL: Stl26 (Serum triglyceride level QTL 26) Rattus norvegicus

Symbol:

Stl26

Name:

Serum triglyceride level QTL 26

RGD ID:

1302789

Previously known as:

Tgl8; Triglyceride level QTL 8

Trait:

blood triglyceride amount (VT:0002644)

Measurement Type:

plasma triglyceride level (CMO:0000548)

LOD Score:

3.1

P Value:

0.0035

Variance:

Not Available

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	218,957,047 - 240,977,220	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	2	1 - 237,043,265	RGD	Rnor5.0
RGSC_v3.4	2	212,168,913 - 242,131,387	RGD	RGSC3.4
RGSC_v3.1	2	212,131,668 - 242,141,990	RGD

Cross Type:

intercross

Strains Crossed:

LEW HTG

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hypercholesterolemia (IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased circulating triglyceride level (QTM)

Experimental Data Annotations Click to see Annotation Detail View

Clinical Measurement

plasma triglyceride level (IDA)

Experimental Condition

control condition (IDA)

Measurement Method

plasma triglyceride analysis (IDA)

Vertebrate Trait

blood triglyceride amount (IDA)

Rat Strain

HTG (IEA)

LEW (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat model of familial combined hyperlipidemia as a result of comparative mapping.	Ueno T, etal., Physiol Genomics 2004 Mar 12;17(1):38-47. Epub 2004 Jan 6.

Region

Markers in Region

The following Markers overlap with this region.

RGD ID

Symbol

Expected Size

Chr

Start

Stop

Species

Match

Position Markers

Flank 1: (D2Rat55)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	203,928,125 - 203,928,301 (+)	MAPPER
Rnor_6.0	2	218,957,047 - 218,957,222	NCBI
Rnor_5.0	2	237,043,090 - 237,043,265	UniSTS
RGSC_v3.4	2	212,168,913 - 212,169,089	RGD
RGSC_v3.4	2	212,168,914 - 212,169,089	UniSTS
RGSC_v3.1	2	212,131,668 - 212,131,843	RGD
Celera	2	196,429,048 - 196,429,217	UniSTS
RH 3.4 Map	2	1481.4	RGD
RH 3.4 Map	2	1481.4	UniSTS
RH 2.0 Map	2	1053.4	RGD
SHRSP x BN Map	2	82.4198	RGD
Cytogenetic Map	2	q41	UniSTS

Peak: (D2Rat61)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	79,924,734 - 79,925,127 (+)	MAPPER
Rnor_6.0	2	68,865,414 - 68,866,454	NCBI
Rnor_5.0	2	88,594,475 - 88,595,515	UniSTS
RGSC_v3.4	2	227,150,052 - 227,150,249	UniSTS
RGSC_v3.4	2	227,150,051 - 227,150,248	RGD
RGSC_v3.1	2	227,136,731 - 227,136,928	RGD
Celera	2	210,543,293 - 210,543,469	UniSTS
RH 3.4 Map	2	1546.8	RGD
RH 3.4 Map	2	1546.8	UniSTS
RH 2.0 Map	2	1129.9	RGD
SHRSP x BN Map	2	88.6498	RGD
FHH x ACI Map	2	101.7399	RGD
Cytogenetic Map	2	q42-q43	UniSTS

Flank 2: (D2Rat111)

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	240,977,105 - 240,977,220	NCBI
Celera	2	216,423,000 - 216,423,132	UniSTS
RH 3.4 Map	2	1564.3	RGD
RH 3.4 Map	2	1564.3	UniSTS
RH 2.0 Map	2	1127.4	RGD
SHRSP x BN Map	2	96.5398	RGD
FHH x ACI Map	2	110.6899	RGD

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Tgl8

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-01	Stl26	Serum triglyceride level QTL 26	Tgl8	Triglyceride level QTL 8	Name updated	68913	APPROVED
2012-10-01	Stl26	Serum triglyceride level QTL 26	Tgl8	Triglyceride level QTL 8	Symbol updated	68687	APPROVED

RGD Curation Notes

Note Type	Note	Reference
qtl_cross_type	intercross
qtl_general	homozygous HTG genotype is associated with higher plasma triglycerides than homozygous LEW and heterozygous genotypes	1299960
qtl_general	LOD 2.8 was observed in F₂ female rats	1299960
qtl_general	number of animals used: 5-6 months old 266 F₂ rats	1299960
qtl_general	measurement method: polyethylene catheters were inserted in the carotid artery and blood was drawn	1299960
qtl_general	software used: one-way analysis of variance (ANOVA)	1299960
qtl_map	syntenic to a human QTL for small, dense LDL cholesterol level	1299960

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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QTL: Stl26 (Serum triglyceride level QTL 26) Rattus norvegicus

Mammalian Phenotype