Cm1 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Cm1 (Cardiac mass QTL 1) Rattus norvegicus

Symbol: Cm1
Name: Cardiac mass QTL 1
RGD ID: 1298525
Trait: heart mass   (VT:0007028)    
Measurement Type: heart wet weight   (CMO:0000069)    
LOD Score: 2.7
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2799,736,187 - 103,146,217RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.07108,889,614 - 112,429,186RGD_MAPPER_PIPELINERnor6.0
Rnor_5.07108,833,186 - 112,367,543RGDRnor5.0
RGSC_v3.47105,412,922 - 108,875,615RGDRGSC3.4
RGSC_v3.17105,447,152 - 108,909,845RGD
Cross Type: Not Available
Strains Crossed: SR/Jr SS/Jr 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
Cardiomegaly  (IAGP)
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait
heart mass  (IDA)

Rat Strain
SR/Jr  (IEA)
SS/Jr  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. Cicila GT, etal., Mamm Genome 1997 Dec;8(12):896-902.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
620921Khdrbs3KH RNA binding domain containing, signal transduction associated 37100837707100995644Rat
1310886Zfatzinc finger and AT hook domain containing799886954100054288Rat
1562153Rps19l1ribosomal protein S19-like 17102435651102436177Rat
1585982R3hdm2-ps2R3H domain containing 2, pseudogene 27101184273101187188Rat
1564548RGD1564548similar to H3 histone, family 3B7100253160100257870Rat
2325392Mir30bmicroRNA 30b7100132589100132675Rat
2325589Mir30dmicroRNA 30d7100136391100136472Rat
2324751Fcf1-ps3Fcf1 rRNA-processing protein, pseudogene 37103065074103065683Rat
7751266LOC102551574uncharacterized LOC1025515747100102553100159947Rat
11479082LOC108351507uncharacterized LOC1083515077100977899100982865Rat
41089210LOC120093934U7 small nuclear RNA7101328875101328934Rat
41147028LOC120093935U7 small nuclear RNA7102247197102247258Rat
41189194LOC120093889uncharacterized LOC1200938897101218098101248598Rat
40928179LOC120093680uncharacterized LOC1200936807100100814100116285Rat
41311854LOC120094008small nucleolar RNA SNORA177101325223101325349Rat
41057908Tox4-ps1TOX high mobility group box family member 4, pseudogene 17100628756100635603Rat
41069368Calm1-ps1calmodulin 1, pseudogene 17100467800100468244Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33749D7Mit325679973595699736220Ratregion
37814D7Rat1002137100865992100866189Ratregion
36661D7Rat151717101772987101773158Ratregion
35845D7Rat161407102920123102920263Ratregion
40036D7Rat1371757100005580100005753Ratregion
38886D7Rat962077102322484102322685Ratregion
39058D7Rat532197100874472100874685Ratregion
39464D7Rat1382007102714177102714373Ratregion
39464D7Rat1382007102714177102714575Ratregion
39468D7Rat1591087100963583100963703Ratregion
40784D7Rat1351477102297359102297520Ratregion
41130D7Rat1362047102228765102228945Ratregion
44283D7Got851437100006584100006727Ratregion
44285D7Got822377100749587100749814Ratregion
44286D7Got861497101283261101283410Ratregion
44296D7Got892017102714117102714318Ratregion
44296D7Got892017102714117102714575Ratregion
44296D7Got892017102714262102714318Ratregion
44299D7Got882187102969204102969422Ratregion
44302D7Got871227102741501102741611Ratregion
60590D7Got7918379992957099929753Ratregion
62494D7Uia12987103146217103146515Ratregion
66593D7Mco120179973598299736187Ratregion
1631297D7Got215917102915988102916080Ratregion
1631395D7Got2481677100749627100749784Ratregion
7205758stSG6244665587101076225101076783Ratregion
7206730stSG60748507101953998101954302Ratregion
7206730stSG60748507101954033101954302Ratregion
5032593RH1345781947100995253100995447Ratregion
5033719RH1398662147100120563100120777Ratregion
5071696RH13523119579988705499887249Ratregion
5068634AU0470272437101569654101569907Ratregion
5060570BE11041017379988750299887675Ratregion
5082643BE1199141647100839897100840061Ratregion
5090657AU0498841367102741495102741631Ratregion
5090279AU0496561777101072720101072897Ratregion
5083093BF3907951507100603593100603743Ratregion
5134360D7Uwm262777100132762100133039Ratregion
Position Markers

Flank 1: (D7Uia1)
Rat AssemblyChrPosition (strand)Source
mRatBN7.27103,146,217 - 103,146,515 (+)MAPPER
Rnor_6.07112,429,186 - 112,429,483NCBI
Rnor_5.07112,367,543 - 112,367,840UniSTS
RGSC_v3.47108,875,615 - 108,875,913RGD
RGSC_v3.47108,875,616 - 108,875,913UniSTS
RGSC_v3.17108,909,845 - 108,910,143RGD
Celera799,574,664 - 99,574,961UniSTS
Cytogenetic Map7 RGD
Flank 2: (D7Mco1)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2799,735,982 - 99,736,187 (+)MAPPER
Rnor_6.07108,889,408 - 108,889,614NCBI
Rnor_5.07108,832,980 - 108,833,186UniSTS
RGSC_v3.47105,412,715 - 105,412,922RGD
RGSC_v3.47105,412,716 - 105,412,922UniSTS
RGSC_v3.17105,446,945 - 105,447,152RGD
Celera796,250,444 - 96,250,648UniSTS
Cytogenetic Map7 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)799736187103146217Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Cm1

RGD Curation Notes
Note Type Note Reference
qtl_map syntenic to mouse salt-induced hypertension QTL Bpq6 (at mouse chromosome 15) 69710
qtl_statistics_details QTL also associated with systolic blood pressure, LOD = 2.0 69710