Cm132 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Cm132 (Cardiac mass QTL 132) Rattus norvegicus

Symbol: Cm132
Name: Cardiac mass QTL 132
RGD ID: 12904715
Previously known as: CakmC18QTL
Trait: heart right ventricle mass   (VT:0007033)    
Measurement Type: heart right ventricle weight to body weight ratio   (CMO:0000914)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,791,251 - 12,205,285RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0187,057,769 - 15,274,626RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0187,012,157 - 15,053,556RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4186,934,443 - 12,677,409RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.LEW-(D18Rat30-D18Chm29)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3916Ttrtransthyretin181194179111951008Rat
71046B4galt6beta-1,4-galactosyltransferase 6181195838212015247Rat
69280Cdh2cadherin 21877767047990934Rat
1311143Dsg2desmoglein 2181184620711904630Rat
1311782Dsc3desmocollin 3181137975911413797Rat
1310768Dsc1desmocollin 1181149993611556801Rat
1309426Dsc2desmocollin 2181145039211482476Rat
1309925Dsg1desmoglein 1181167468711705383Rat
1309102Trappc8trafficking protein particle complex subunit 8181210387412180422Rat
735015Dsg4desmoglein 4181172097511756234Rat
1307302Chst9carbohydrate sulfotransferase 91865763916851078Rat
1560045LOC498826LRRGT00165181219476712207125Rat
1561788Rrs1-ps8ribosome biogenesis regulator 1 homolog, pseudogene 8181066424110665367Rat
1583536Rpl6-ps3ribosomal protein L6, pseudogene 31894849369514865Rat
1592101Eef1g-ps2eukaryotic translation elongation factor 1 gamma, pseudogene 2181143704511438463Rat
1592102Lap3-ps1leucine aminopeptidase 3, pseudogene 1181158152811582618Rat
1592103Dsg3desmoglein 3181179890511833415Rat
1588520Phb1-ps12prohibitin 1, pseudogene 121869698746971761Rat
1595554Peds1-ps1plasmanylethanolamine desaturase 1, pseudogene 1181020945410281082Rat
1596770Rpl3-ps1ribosomal protein L3, pseudogene 1181160765011608894Rat
1596759Api5-ps1apoptosis inhibitor 5, pseudogene 1181163625111642861Rat
1598047LOC681224similar to cyclin D binding myb-like transcription factor 1181122702911229258Rat
2324544Tuba1b-ps14tubulin, alpha 1B, pseudogene 14181178767211788464Rat
6502448Ipo5-ps1importin 5, pseudogene 1181203772312039781Rat
7635703LOC102551904uncharacterized LOC102551904181183503811837513Rat
7598702LOC102553404uncharacterized LOC102553404181100116211019181Rat
7733249LOC102551486uncharacterized LOC102551486181201461012021819Rat
7670702LOC102551809uncharacterized LOC102551809181192270811928930Rat
9188764LOC10369417060S ribosomal protein L27a pseudogene1872017497202240Rat
11458426Rps26-ps3ribosomal protein S26, pseudogene 3181213877112139362Rat
11431944LOC108348751uncharacterized LOC1083487511868532376865278Rat
11419083LOC108348752uncharacterized LOC1083487521870559367070705Rat
11391260LOC108348753uncharacterized LOC1083487531889629389079803Rat
41321995Tuba1a-ps4tubulin, alpha 1A, pseudogene 4181178826111791295Rat
41168946LOC120098418small nucleolar RNA U3181113045211130556Rat
41212325LOC120098434U6 spliceosomal RNA1875149757515080Rat
41193066LOC120098272uncharacterized LOC120098272181208142912093465Rat
41369178LOC120098221uncharacterized LOC1200982211881283678132815Rat
41397459LOC120098389small nucleolar RNA SNORA171869943926994528Rat
41271556LOC120098382small nucleolar RNA SNORA171882652818265410Rat
40972921Trnas-aga31transfer RNA serine (anticodon AGA) 311883872238387304Rat
41033437LOC120098417small nucleolar RNA U31896485019648587Rat
41237235LOC120098388U1 spliceosomal RNA181212848412128622Rat
41304700LOC120098203uncharacterized LOC1200982031879106227951444Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
11461D18Mit1245181194429911944544Ratregion
11462D18Wox7200181194427311944420Ratregion
37578D18Rat65195181179151811791709Ratregion
35366D18Rat28158181136754511367701Ratregion
38430D18Rat622251867912516791521Ratregion
40076D18Rat107150181141823611418394Ratregion
42420D18Rat1522101872660117266214Ratregion
43112D18Rat147236181171900111719218Ratregion
45580D18Got13192181091246810912660Ratregion
45582D18Got112031898795779879780Ratregion
45584D18Got101281884879928488120Ratregion
45585D18Got122861887803238780609Ratregion
45588D18Got91231873635257363648Ratregion
45589D18Got81371869533626953458Ratregion
45589D18Got81371869533626953499Ratregion
625821D18Got61761879390027939178Ratregion
67278D18Arb1375181194285711943232Ratregion
1578823D18Chm88172181150186711502035Ratregion
1578828D18Chm161701881649728165134Ratregion
1631641D18Wox241551877768877777044Ratregion
1578884D18Chm19210181208366712083877Ratregion
1578945D18Chm87199181125670711256906Ratregion
1578949D18Chm91219181220506612205285Ratregion
1578955D18Chm841511878661207866271Ratregion
1578999D18Chm862081895400719540275Ratregion
1579008D18Chm282411898796209879861Ratregion
1579043D18Chm272361887925558792791Ratregion
1579086D18Chm152201873155907315814Ratregion
1579112D18Chm851771891195989119775Ratregion
1579120D18Chm29240181179611611796356Ratregion
1579160D18Chm93237181194890611949143Ratregion
1579175D18Chm18184181081036610810552Ratregion
1628499D18Got1131091896692829669386Ratregion
1633713D18Wox23181195891011959165Ratregion
5026066RH1307751951877776187777813Ratregion
5031644AU0476241261883394828339605Ratregion
5029009RH143169110181190448411904594Ratregion
5032875RH136808130181190446511904595Ratregion
5025722RH129406186181196184611962032Ratregion
5028318D10S1559125181185518011855305Ratregion
5028318D10S1559125181185518011855305Ratregion
5051927RH94739101181195088311950985Ratregion
5055683RH143942120181201445912014579Ratregion
5058736BF3870081981878599717860169Ratregion
505217510.MMHAP35FRD7.seq2011875348227535023Ratregion
5044056RH130384181181203771012037891Ratregion
5046500RH131789220181137753511377753Ratregion
5040734RH128452180181213454112134721Ratregion
5040946RH128574210181210415212104362Ratregion
5071170RH1349281901879564397956630Ratregion
5073398RH137413195181170322111703416Ratregion
5066744AU0481762241874512237451447Ratregion
5069190AU0466591271878950107895134Ratregion
5061624BF3969002261879329397933165Ratregion
5090347AU049697214181040451910404732Ratregion
5080798RH141787150181192871811928868Ratregion
5081304RH142083220181170388911704109Ratregion
5084902AA85196390181145052911450619Ratregion
5506105UniSTS:49836801877767637777432Ratregion
5499583At-8L-2631132181107969411080826Ratregion
5500184REN160272551878102667810521Ratregion
5502263C76941205181203785612038058Ratregion
5502662X97986134181150283011502964Ratregion
5502257L33779111181145202911452140Ratregion
5502413RH124760215181195075711950972Ratregion
Position Markers

Flank 1: (D18Rat62)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,791,251 - 6,791,521 (+)MAPPER
Rnor_6.0187,057,769 - 7,058,038NCBI
Rnor_5.0187,012,157 - 7,012,426UniSTS
RGSC_v3.4186,934,493 - 6,934,762UniSTS
RGSC_v3.4186,934,443 - 6,934,805RGD
RGSC_v3.1186,934,493 - 6,934,762RGD
Celera186,813,616 - 6,813,887UniSTS
RH 3.4 Map1873.4RGD
RH 3.4 Map1873.4UniSTS
RH 2.0 Map18796.0RGD
SHRSP x BN Map182.52RGD
FHH x ACI Map184.99RGD
Cytogenetic Map18p13UniSTS
Flank 2: (D18Chm91)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21812,205,066 - 12,205,285 (-)MAPPER
Rnor_6.01815,274,408 - 15,274,626NCBI
Rnor_5.01815,053,338 - 15,053,556UniSTS
RGSC_v3.41812,677,191 - 12,677,409UniSTS
Celera1812,203,981 - 12,204,199UniSTS
Cytogenetic Map20q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18679125112205285Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18679125112205285Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18679125112205285Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18679125112205285Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18679125112205285Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 8 gender: male 1599557
qtl_general also affects heart left ventricle mass, aortic mass and kidney mass but has no effect on body mass or blood pressure 1599557
qtl_map 7.4 Mb 1599557
qtl_statistics_details software package used: ANOVA followed by Dunnett test in the SYSTAT 9 program 1599557
qtl_trait_method heart was dissected into left ventricle plus septum and right ventricle 1599557
qtl_trait_method measurement method: selected males were weaned at 21 days of age then fed 2% NaCl diet starting from 35 days of age, at 14 weeks animals were decapitated, organs removed, blotted and weighed 1599557