Cm117 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Cm117 (Cardiac mass QTL 117) Rattus norvegicus

Symbol: Cm117
Name: Cardiac mass QTL 117
RGD ID: 12903952
Previously known as: BpcaKmC16QTL
Trait: heart right ventricle mass   (VT:0007033)    
Measurement Type: heart right ventricle weight to body weight ratio   (CMO:0000914)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8161 - 839,230RGD_MAPPER_PIPELINE
mRatBN7.216832,380 - 2,995,225RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0161,550,330 - 3,439,525RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0161,534,551 - 3,405,986RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.416819,369 - 3,080,748RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.LEW-(D16Got3-D16Rat112)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)



Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1305574Polr3aRNA polymerase III subunit A165606695060Rat
621040Rps24ribosomal protein S241695429101146Rat
402032885LOC134482310uncharacterized LOC13448231016150929550413Rat
7525846LOC102551656uncharacterized LOC10255165616218038233046Rat
41311446LOC120097510spindlin-1-like16223890224929Rat
40961170LOC120097431uncharacterized LOC12009743116589810599726Rat
41048147LOC120097393uncharacterized LOC12009739316684462719775Rat
402354529LOC134482311uncharacterized LOC13448231116685717691016Rat
7724613LOC102552347uncharacterized LOC10255234716760908768627Rat
402138634LOC134482435uncharacterized LOC13448243516761597764295Rat
402374788LOC134482437uncharacterized LOC13448243716789914804475Rat
9185666LOC103693859uncharacterized LOC10369385916794424953464Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36892D16Rat1211116387123387234Ratregion
39456D16Rat8814416839086839230Ratregion
42409D16Rat11224116117469117710Ratregion
1357999D16Chm1419516134016134211Ratregion
1358022D16Chm3120716312389312596Ratregion
1358027D16Chm2520716545053545260Ratregion
1358033D16Chm2419516134016134211Ratregion
5065648BF40614824016528006528246Ratregion
Position Markers

Flank 1: (D16Chm66)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2162,995,225 - 2,995,463 (+)MAPPER
Rnor_6.0163,439,525 - 3,439,762NCBI
Rnor_5.0163,405,986 - 3,406,223UniSTS
RGSC_v3.4163,080,748 - 3,080,985UniSTS
Celera162,957,693 - 2,957,930UniSTS
Cytogenetic Map16p16UniSTS
Flank 2: (D16Rat88)
Rat AssemblyChrPosition (strand)Source
GRCr816839,086 - 839,230 (+)Marker Load Pipeline
mRatBN7.216832,236 - 832,380 (+)MAPPER
Rnor_6.0161,550,187 - 1,550,330NCBI
Rnor_5.0161,534,408 - 1,534,551UniSTS
RGSC_v3.416819,225 - 819,369RGD
RGSC_v3.416819,226 - 819,369UniSTS
Celera16812,123 - 812,266UniSTS
RGSC_v3.116819,226 - 819,369RGD
RH 3.4 Map18655.3RGD
RH 3.4 Map18655.3UniSTS
RH 2.0 Map18257.7RGD
SHRSP x BN Map161.1999RGD


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
12903278Am16Aortic mass QTL 160.019aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)161839230Rat
12903279Cm115Cardiac mass QTL 1150.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)161839230Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
631524Bp75Blood pressure QTL 750.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)161177108157035Rat
12903952Cm117Cardiac mass QTL 1170.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)161839230Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
12903281Cm116Cardiac mass QTL 1160.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)161839230Rat
12903954Bw186Body weight QTL 1860.011body mass (VT:0001259)body weight (CMO:0000012)161839230Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168392304234212Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
2301404Bp321Blood pressure QTL 3210.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)161839230Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 9 gender: male 1599557
qtl_general also affects heart mass, heart left ventricle mass, aortic mass, kidney mass, body mass and blood pressure 1599557
qtl_map 3.5 Mb 1599557
qtl_statistics_details software package used: ANOVA followed by Dunnett test in the SYSTAT 9 program 1599557
qtl_trait_method measurement method: selected males were weaned at 21 days of age then fed 2% NaCl diet starting from 35 days of age, at 14 weeks animals were decapitated, organs removed, blotted and weighed 1599557
qtl_trait_method heart was dissected into left ventricle plus septum and right ventricle 1599557