Cm88 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Cm88 (Cardiac mass QTL 88) Rattus norvegicus

Symbol: Cm88
Name: Cardiac mass QTL 88
RGD ID: 12879842
Also known as: BpcakmC2QTL3
Trait: heart left ventricle mass   (VT:0007031)    
Measurement Type: heart left ventricle weight to body weight ratio   (CMO:0000530)    
LOD Score: Not Available
P Value: 0.042
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22142,323,368 - 146,786,035RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0227,161,361 - 148,295,267RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0246,277,412 - 167,706,439RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42147,424,195 - 152,050,550RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.MNS-(D2Chm51-D2Rat341)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
1. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3242P2ry1purinergic receptor P2Y12145241975145248186Rat
70912P2ry14purinergic receptor P2Y142143372697143413213Rat
628779Clrn1clarin 12143084030143130948Rat
631440Aadacarylacetamide deacetylase2144163436144186086Rat
628668Mbnl1muscleblind-like splicing regulator 12144639819144814395Rat
620790Serp1stress-associated endoplasmic reticulum protein 12142757254142761243Rat
735030Igsf10immunoglobulin superfamily, member 102143575710143605044Rat
621681P2ry12purinergic receptor P2Y122143481468143523340Rat
1303193Sucnr1succinate receptor 12144219066144230568Rat
620778Siah2siah E3 ubiquitin protein ligase 22142913924142931752Rat
620591Rap2bRAP2B, member of RAS oncogene family2145599714145600265Rat
1307852Gpr87G protein-coupled receptor 872143439741143440901Rat
1562559Arhgef26Rho guanine nucleotide exchange factor 262146740336146850918Rat
1563197Aadacl2arylacetamide deacetylase-like 22144123557144144159Rat
1561998RGD1561998similar to hypothetical protein C130079G132143883313143910452Rat
1559622RGD1559622similar to hypothetical protein C130079G132143761288143800486Rat
1559451Erich6glutamate-rich 62142851905142878010Rat
1359128Selenotselenoprotein T2142804387142821438Rat
1560162RGD1560162similar to hypothetical protein C130079G132144077936144098546Rat
1560324RGD1560324similar to hypothetical protein C130079G132143936599143975506Rat
1302941P2ry13purinergic receptor P2Y132143470437143476360Rat
1585271Gpr171G protein-coupled receptor 1712143360187143366665Rat
1593169Tsc22d2TSC22 domain family, member 22142646778142697977Rat
1592212Med12lmediator complex subunit 12L2143253048143576507Rat
1590976LOC690857similar to mitochondrial transcription termination factor 12144912502144915405Rat
1589591Eif2aeukaryotic translation initiation factor 2A2142761303142794767Rat
1589858LOC690921similar to MAPKK-like protein kinase2146422640146423799Rat
1592032LOC365803hypothetical LOC3658032144606370144613638Rat
2318158LOC100362430FUS interacting protein (serine-arginine rich) 1-like2145547075145547780Rat
2320352LOC100361313rCG49992-like2142636554142636927Rat
6494152LOC10091119160 kDa heat shock protein, mitochondrial-like2146424660146426592Rat
7736144LOC102551458uncharacterized LOC1025514582144249483144259818Rat
9158000LOC103691561activated RNA polymerase II transcriptional coactivator p15 pseudogene2143786767143787385Rat
11362385Mindy4bMINDY family member 4B2143026685143061966Rat
11451529LOC108350188heterogeneous nuclear ribonucleoprotein A1 pseudogene2146203311146204345Rat
11380114LOC10835001860S ribosomal protein L7a-like2143142439143143338Rat
11487723LOC108350022uncharacterized LOC1083500222145011388145080528Rat
41379557LOC120100831uncharacterized LOC1201008312143363352143370752Rat
41379567LOC120100580protein kinase C-binding protein 1-like2144832892144834587Rat
41253353LOC120101014homeobox protein TGIF1-like2144497737144530432Rat
41146639LOC120093098arylacetamide deacetylase-like 22144000814144045928Rat
41264623LOC120100830uncharacterized LOC1201008302142885611142893347Rat
41392418LOC120101116U2 spliceosomal RNA2142505335142505414Rat
41153850LOC120101261small nucleolar RNA SNORA482146703955146704098Rat
41216218LOC120100832uncharacterized LOC1201008322144589149144602088Rat
41184903LOC120101169U6 spliceosomal RNA2144435226144435328Rat
41272099LOC120100833protein FAM246C-like2144667224144670864Rat
41350546NEWGENE_40938314transfer RNA serine (anticodon AGA)2145791195145791276Rat
40946467LOC120100827uncharacterized LOC1201008272142355389142413239Rat
41024370LOC120101133U4 spliceosomal RNA2144593202144593324Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
34005D2Mit81502143657411143657569Ratregion
37034D2Rat371502145500022145500154Ratregion
36701D2Rat1461682144536601144536760Ratregion
36775D2Rat351622144228428144228589Ratregion
35857D2Rat361272143157029143157156Ratregion
40328D2Rat2571292142843294142843423Ratregion
41128D2Rat2252432145196438145196688Ratregion
66367D2Mco381882145496743145496934Ratregion
67258D2Arb93102142709254142709417Ratregion
67258D2Arb93102142709148142709642Ratregion
67258D2Arb93102142709148142709417Ratregion
67751D2Uwm321992142909618142909825Ratregion
1358020D2Chm462042146785831146786035Ratregion
1358049D2Chm512272146368688146368915Ratregion
1358052D2Chm902422142323368142323610Ratregion
1636528D2Got3321312144619698144619827Ratregion
7193089D2Mgh271392142709158142709642Ratregion
7193089D2Mgh271392142709158142709297Ratregion
5035979PMC34459P16522145242883145243535Ratregion
5031272PMC123072P22512145242893145243144Ratregion
5026930RH1340802002143594767143594959Ratregion
5030075BE1100111742143532319143532493Ratregion
5024976BB2423491242143439855143439979Ratregion
5030683BI3017922052143526741143526946Ratregion
5054253RH1431181012142805005142805106Ratregion
5057532BF3920581182143482492143482610Ratregion
5056179RH1442292912145608390145608681Ratregion
5056921RH1446571772142787364142787540Ratregion
5059808BE0979451512143481728143481879Ratregion
5045276RH1310852022142821203142821405Ratregion
5048138RH13273002142794269142794452Ratregion
5042084RH1292301802142758935142759115Ratregion
5049520RH1335281912146190773146190964Ratregion
5043144RH1298571832144814118144814301Ratregion
5077500RH1397922172144669731144669948Ratregion
5076426RH1391681812143445419143445598Ratregion
5071036RH1348491802143557296143557476Ratregion
5065122BF4059881592145244674145244834Ratregion
5062948BF4100862152143505177143505392Ratregion
5063152BI3013761502146019213146019363Ratregion
5066442AU0483542792146569293146569572Ratregion
5061652BF3969921872142649265142649452Ratregion
5083575BI276286992143252273143252372Ratregion
5081374AI0713841802143470511143470691Ratregion
5086217BQ2060622182146738594146738812Ratregion
5083123BF3908091932143471685143471877Ratregion
5081617BE1176411552145247400145247555Ratregion
5085571BQ1991821602142693381142693541Ratregion
5081991BE1189991502144667617144667767Ratregion
5507033fl05f09.x12002145599793145599993Ratregion
5502561RH1253401832142820626142820809Ratregion
Position Markers

Flank 1: (D2Chm90)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22142,323,368 - 142,323,610 (+)MAPPER
Rnor_6.02148,295,267 - 148,295,508NCBI
Rnor_5.02167,706,439 - 167,706,680UniSTS
RGSC_v3.42147,424,195 - 147,424,436UniSTS
Celera2136,755,765 - 136,756,448UniSTS
Celera2136,755,765 - 136,755,986UniSTS
Cytogenetic Map2 RGD
Flank 2: (D2Chm46)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22146,785,831 - 146,786,035 (+)MAPPER
Rnor_6.0227,161,158 - 27,161,361NCBI
Rnor_5.0246,277,209 - 46,277,412UniSTS
RGSC_v3.42152,050,347 - 152,050,550UniSTS
Celera2141,125,225 - 141,125,402UniSTS
Cytogenetic Map2q31UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
12879830Bw178Body weight QTL 1780.001body mass (VT:0001259)body weight (CMO:0000012)2137219876142323610Rat
12879831Cm82Cardiac mass QTL 820.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2137219876142323610Rat
12879832Cm83Cardiac mass QTL 830.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2137219876142323610Rat
12879833Cm84Cardiac mass QTL 840.001heart right ventricle mass (VT:0007033)heart weight to body weight ratio (CMO:0000074)2137219876142323610Rat
12879834Am1Aortic mass QTL 10.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2137219876142323610Rat
12879835Kidm60Kidney mass QTL 600.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2137219876142323610Rat
1549841Bp256Blood pressure QTL 2560.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2137219876142323610Rat
7488931Bp367Blood pressure QTL 3670.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2139401804142323610Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2142323368146786035Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2142323368146786035Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2142323368146786035Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2142323368146786035Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368147803808Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 8 gender: male 1599557
qtl_general also affects heart mass, aortic mass, kidney mass and blood pressure, but has no effect on body mass or heart right ventricle mass 1599557
qtl_statistics_details software package used: ANOVA followed by Dunnett test in the SYSTAT 9 program 1599557
qtl_trait_method measurement method: selected males were weaned at 21 days of age then fed 2% NaCl diet starting from 35 days of age, at 14 weeks animals were decapitated, organs removed, blotted and weighed 1599557
qtl_trait_method heart was dissected into left ventricle plus septum and right ventricle 1599557