Bss113 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bss113 (Bone structure and strength QTL 113) Rattus norvegicus

Symbol: Bss113
Name: Bone structure and strength QTL 113
RGD ID: 11528620
Trait: femur morphology trait   (VT:0000559)    
Measurement Type: femoral neck width   (CMO:0001695)    
LOD Score: 9.75
P Value: 1.7E-10
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,490,648 - 19,241,681RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0312,236,221 - 15,217,668RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0317,570,016 - 20,527,281RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4312,200,198 - 14,999,876RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: NAft:HS 



Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
NAft:HS  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Fine mapping of bone structure and strength QTLs in heterogeneous stock rat. Alam I, etal., Bone. 2015 Dec;81:417-26. doi: 10.1016/j.bone.2015.08.013. Epub 2015 Aug 19.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2319500Ralgps1Ral GEF with PH domain and SH3 binding motif 131643332316670276Rat
620004Angptl2angiopoietin-like 231651718516547024Rat
1596130Zbtb34zinc finger and BTB domain containing 3431670335516726082Rat
1310287Zbtb43zinc finger and BTB domain containing 4331674453516763854Rat
7578982LOC102550017uncharacterized LOC10255001731677835916781260Rat
41260489LOC120102022small nucleolar RNA SNORA4831685366616853809Rat
620843Lmx1bLIM homeobox transcription factor 1 beta31686219516940899Rat
9300457Rpl39l3ribosomal protein L39 like 331696991316970148Rat
1309709Mvb12bmultivesicular body subunit 12B31703400217192658Rat
41014645LOC120101526uncharacterized LOC12010152631724139317247946Rat
11425803LOC108350352uncharacterized LOC10835035231737963817415805Rat
1307198Pbx3PBX homeobox 331748869117682412Rat
9255683LOC103691768uncharacterized LOC10369176831762428617653427Rat
11375987LOC108350353uncharacterized LOC10835035331771249617715730Rat
1305363Mapkap1MAPK associated protein 131771581317918387Rat
6490845Rps7-ps1ribosomal protein S7, pseudogene 131774510017745785Rat
1307479Gapvd1GTPase activating protein and VPS9 domains 131796834518041888Rat
2843Hspa5heat shock protein family A (Hsp70) member 531805550718059969Rat
1310612RabepkRab9 effector protein with kelch motifs31806129918083191Rat
1310460Fbxw2F-box and WD repeat domain containing 231808885918114387Rat
9424697B3galt9beta-1,3-galactosyltransferase 931812162018124149Rat
1308434Psmd5proteasome 26S subunit, non-ATPase 531813371518151000Rat
1564854CutalcutA divalent cation tolerance homolog-like31815430018174957Rat
1310390Phf19PHD finger protein 1931817528118197289Rat
41148686Rnu6-1256RNA, U6 small nuclear 125631819866018198758Rat
1596290Traf1TNF receptor-associated factor 131822202418242163Rat
2237C5complement C531827069618361994Rat
1308742C5l1complement C5 like 131840171618420064Rat
1305317Cntrlcentriolin31842814718500362Rat
620881Rab14RAB14, member RAS oncogene family31850195318523253Rat
7626419LOC102554040uncharacterized LOC10255404031854880318551679Rat
1303089Gsngelsolin31858516618638404Rat
1305109Stomstomatin31864505818667343Rat
11415833Rps29-ps18ribosomal protein S29, pseudogene 1831865282818653581Rat
1565200Ggta1l1glycoprotein, alpha-galactosyltransferase 1-like 131868467618701674Rat
7519388LOC102548933uncharacterized LOC10254893331868483718704251Rat
41302246LOC120101528spermidine synthase-like31870954818710782Rat
15600294930402F06RiklRIKEN cDNA 4930402F06 gene like31871144718729464Rat
629476Ggta1glycoprotein alpha-galactosyltransferase 131873298518824916Rat
41223777LOC120101529uncharacterized LOC12010152931880970818826377Rat
41235057LOC120101530uncharacterized LOC12010153031883080318840164Rat
7519941LOC102549213uncharacterized LOC10254921331885924518864078Rat
41334896LOC120101531uncharacterized LOC12010153131885969018860308Rat
40939483LOC120101532uncharacterized LOC12010153231886873618875078Rat
1564343Rps16-ps8ribosomal protein S16, pseudogene 831889902818899541Rat
41255400LOC120101533uncharacterized LOC12010153331890657418915565Rat
621686Dab2ipDAB2 interacting protein31891529019086282Rat
1588742Ttll11tubulin tyrosine ligase like 1131910989119335077Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10260D3Rat5215631831145418311610Ratregion
34252D3Mgh1913231922714719227279Ratregion
36354D3Mit2221031916237119162581Ratregion
35609D3Rat5318031737470317374883Ratregion
42641D3Rat27821631909133519091551Ratregion
40854D3Rat19235731774916217749521Ratregion
43611D3Got1121531687564716875862Ratregion
43616D3Got913231696220116962333Ratregion
43618D3Got1012131741247617412594Ratregion
43626D3Got817731916237919162556Ratregion
66452D3Mco1820031740031017400510Ratregion
728012D3Chm1522331740644217406665Ratregion
728028D3Chm722731760028217600509Ratregion
728038D3Chm619131740552217405713Ratregion
67266D3Arb521031673546416735674Ratregion
1640270D3Got20216431667844616678612Ratregion
1640611D3Cebr721131827815818278369Ratregion
5036213D2Wsu141e20931805968618059895Ratregion
5036233RH12584824531775201517752260Ratregion
5029085RH14346214831835764618357794Ratregion
5029389RH14460615231890659718906749Ratregion
5029963BF38826316631806103018061196Ratregion
5025340RH12794221031864442318644633Ratregion
8663472rs106373454031897522018975220Ratregion
5025578RH12886521031703408417034294Ratregion
5033671RH13968120431815050818150712Ratregion
5031149BE11638815531898651018986665Ratregion
5054949RH14351913531771658517716720Ratregion
5055813RH14401710931768489017684999Ratregion
5050284RH13396720631767253817672744Ratregion
5051326AW26036312331654769916547822Ratregion
5054251RH14311723331823621918236452Ratregion
5044398RH13058019331813380318133996Ratregion
5044176RH13045321631791708617917302Ratregion
5046024RH13151519431832607018326264Ratregion
5045798RH13138518631796961417969800Ratregion
5047750RH13250719131840877918408970Ratregion
5048318RH13283419731864514218645339Ratregion
5049802RH13369020131806272718062928Ratregion
5047286RH13224019231810742918107621Ratregion
5048408RH13288615031852636918526519Ratregion
5039598RH12779719431873318318733377Ratregion
5040392RH12825718331863818118638364Ratregion
5042774RH12963818331674463316745927Ratregion
5074284RH13792712731718993217190059Ratregion
5074562RH13808813031801663218016762Ratregion
5078406RH14032314431737881017378954Ratregion
5078404RH14032214531911030719110452Ratregion
5073382RH13740421331809822518098438Ratregion
5074364RH13797419031724312417243314Ratregion
5071264RH13498220731808702018087227Ratregion
5072444RH13685319531850985318510048Ratregion
5070099RH9447215831805971818059876Ratregion
5069148AU04669215731821944818219605Ratregion
5070434AI59152911131791804117918152Ratregion
5063762AW53510715431695497116955125Ratregion
5060500BE11023316231806137218061534Ratregion
5063956BE12031515131810266018102811Ratregion
5060330AW53147719831717902617179224Ratregion
5061842AW53384018031881100318811183Ratregion
5064570BE10812815031912737819127528Ratregion
5082151BI28002814931890659718906746Ratregion
5087797D2Wsu17e20531805965818059863Ratregion
5087905Hspa513331805967218059805Ratregion
5089789AU04936419131814751818147709Ratregion
5089717AU04932114731687774416877891Ratregion
5090291AU04966413631922715719227293Ratregion
5090517AU04979820031868799918688199Ratregion
5081104RH14196722031724146017241680Ratregion
5089061AU04893118531851221418512399Ratregion
5086743AA81918019631654777116547967Ratregion
5085722BQ20338018831843735618437544Ratregion
5504145UniSTS:25918053431805617118056705Ratregion
5504930Zik112331867235918672482Ratregion
5506131UniSTS:4984326631861305518613121Ratregion
5506539HSPA5_98879631805908418059880Ratregion
5506821G4613020231661423916614441Ratregion
5500831G0709310731748921117489318Ratregion
5502567RH12536827331805916418059437Ratregion
11528616rs10698495631754241117542411Ratregion
11528617rs10675850031649064816490648Ratregion
11528618rs10698764431924168119241681Ratregion
Position Markers

Flank 1: (rs106758500)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,490,648 - 16,490,648RGD
Rnor_6.0312,236,221 - 12,236,221RGD
Peak: (rs106984956)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2317,542,411 - 17,542,411RGD
Rnor_6.0313,294,746 - 13,294,746RGD
Flank 2: (rs106987644)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2319,241,681 - 19,241,681RGD
Rnor_6.0315,217,668 - 15,217,668RGD


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
11528620Bss113Bone structure and strength QTL 1139.752e-10femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)31649064819241681Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 1524 HS rats (728 male, 796 female) were used. 11528619
qtl_general measurement method: Rats on a standard diet were euthanized at 17 to 20 weeks of age, and left femurs were measured using digital calipers (Mitutoyo, Aurora, IL). 11528619