Tmigd3 (transmembrane and immunoglobulin domain containing 3) - Rat Genome Database

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Gene: Tmigd3 (transmembrane and immunoglobulin domain containing 3) Mus musculus
Analyze
Symbol: Tmigd3 (Ensembl: Gm53046)
Name: transmembrane and immunoglobulin domain containing 3 (Ensembl:predicted gene, 53046)
RGD ID: 9589839
MGI Page MGI
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of cell migration; and negative regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study essential thrombocythemia. Orthologous to human TMIGD3 (transmembrane and immunoglobulin domain containing 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700001d09rik; 4930578J19Rik; adenosine receptor A3; RIKEN cDNA 1700001D09; Tg(H2-K-CALR*)del52Shmd; transmembrane domain-containing protein TMIGD3
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,778,174 - 105,831,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,811,799 - 105,826,108 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl3105,778,174 - 105,816,242 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl3105,778,219 - 105,831,358 (+)EnsemblGRCm39 Ensembl
GRCm383105,870,858 - 105,924,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,904,483 - 105,918,792 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,870,858 - 105,908,926 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,870,903 - 105,924,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv363105,998,963 - 106,052,092 (+)NCBIMGSCv36mm8
Celera3108,059,748 - 108,112,934 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635   PMID:27807369   PMID:32219445  


Genomics

Comparative Map Data
Tmigd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,778,174 - 105,831,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,811,799 - 105,826,108 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl3105,778,174 - 105,816,242 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl3105,778,219 - 105,831,358 (+)EnsemblGRCm39 Ensembl
GRCm383105,870,858 - 105,924,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,904,483 - 105,918,792 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,870,858 - 105,908,926 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,870,903 - 105,924,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv363105,998,963 - 106,052,092 (+)NCBIMGSCv36mm8
Celera3108,059,748 - 108,112,934 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
TMIGD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,483,348 - 111,563,962 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,483,348 - 111,563,962 (-)EnsemblGRCh38hg38GRCh38
GRCh371112,025,970 - 112,106,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p13.2NCBI
CHM1_11112,140,977 - 112,221,590 (-)NCBICHM1_1
T2T-CHM13v2.01111,498,030 - 111,578,832 (-)NCBIT2T-CHM13v2.0
Tmigd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,027,286 - 196,103,430 (+)NCBIGRCr8
mRatBN7.22193,338,950 - 193,415,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,338,950 - 193,415,105 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,933,404 - 201,009,584 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,829,211 - 198,905,343 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,646,168 - 193,722,310 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02208,478,373 - 208,557,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,323,882 - 208,557,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,900,017 - 227,978,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,107,970 - 201,186,359 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2186,040,322 - 186,117,254 (+)NCBICelera
Cytogenetic Map2q34NCBI
TMIGD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11763,904,582 - 63,907,044 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1763,418,171 - 63,420,460 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01765,076,072 - 65,078,361 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11763,811,019 - 63,813,306 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01763,869,840 - 63,872,128 (+)NCBIUNSW_CanFamBas_1.0
TMIGD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,854,357 - 108,873,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,814,405 - 108,871,101 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24118,996,431 - 119,053,021 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Tmigd3
1649 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse


Sequence


Ensembl Acc Id: ENSMUST00000000574   ⟹   ENSMUSP00000000574
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,811,737 - 105,816,242 (+)Ensembl
Ensembl Acc Id: ENSMUST00000010279   ⟹   ENSMUSP00000010279
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,778,223 - 105,831,352 (+)Ensembl
GRCm38.p6 Ensembl3105,870,907 - 105,924,036 (+)Ensembl
Ensembl Acc Id: ENSMUST00000164730   ⟹   ENSMUSP00000126710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,778,174 - 105,815,669 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196748   ⟹   ENSMUSP00000143674
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,811,799 - 105,826,108 (+)Ensembl
GRCm38.p6 Ensembl3105,904,483 - 105,918,792 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197613
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,812,011 - 105,813,673 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197907
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,778,219 - 105,779,948 (+)Ensembl
GRCm38.p6 Ensembl3105,870,903 - 105,872,632 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198080   ⟹   ENSMUSP00000143300
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,821,452 - 105,831,355 (+)Ensembl
GRCm38.p6 Ensembl3105,914,136 - 105,924,039 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,778,293 - 105,779,178 (+)Ensembl
GRCm38.p6 Ensembl3105,870,977 - 105,871,862 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199977   ⟹   ENSMUSP00000142671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,821,452 - 105,831,358 (+)Ensembl
GRCm38.p6 Ensembl3105,914,136 - 105,924,042 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200482   ⟹   ENSMUSP00000142695
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,778,223 - 105,831,271 (+)Ensembl
GRCm38.p6 Ensembl3105,870,907 - 105,923,955 (+)Ensembl
RefSeq Acc Id: NM_001174169   ⟹   NP_001167640
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393105,778,174 - 105,816,244 (+)NCBI
GRCm383105,870,858 - 105,908,928 (+)NCBI
Celera3108,059,748 - 108,112,934 (+)NCBI
Sequence:
RefSeq Acc Id: NM_027025   ⟹   NP_081301
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393105,778,174 - 105,831,360 (+)NCBI
GRCm383105,870,858 - 105,924,044 (+)NCBI
Celera3108,059,748 - 108,112,934 (+)NCBI
Sequence:
RefSeq Acc Id: NP_081301   ⟸   NM_027025
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9DAR9 (UniProtKB/Swiss-Prot),   G3X8R9 (UniProtKB/TrEMBL),   A0A0G2JE84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001167640   ⟸   NM_001174169
- Peptide Label: isoform 3
- UniProtKB: Q497R5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000143300   ⟸   ENSMUST00000198080
Ensembl Acc Id: ENSMUSP00000142671   ⟸   ENSMUST00000199977
Ensembl Acc Id: ENSMUSP00000143674   ⟸   ENSMUST00000196748
Ensembl Acc Id: ENSMUSP00000010279   ⟸   ENSMUST00000010279
Ensembl Acc Id: ENSMUSP00000142695   ⟸   ENSMUST00000200482
Ensembl Acc Id: ENSMUSP00000000574   ⟸   ENSMUST00000000574
Ensembl Acc Id: ENSMUSP00000126710   ⟸   ENSMUST00000164730
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3X8R9-F1-model_v2 AlphaFold G3X8R9 1-209 view protein structure

Promoters
RGD ID:6881942
Promoter ID:EPDNEW_M4422
Type:initiation region
Name:Tmigd3_3
Description:Mus musculus transmembrane and immunoglobulin domain containing3 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4423  EPDNEW_M4425  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383105,870,907 - 105,870,967EPDNEW
RGD ID:6881944
Promoter ID:EPDNEW_M4423
Type:single initiation site
Name:Tmigd3_1
Description:Mus musculus transmembrane and immunoglobulin domain containing3 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4422  EPDNEW_M4425  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383105,894,048 - 105,894,108EPDNEW
RGD ID:6881946
Promoter ID:EPDNEW_M4424
Type:multiple initiation site
Name:Adora3_1
Description:Mus musculus adenosine A3 receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383105,904,411 - 105,904,471EPDNEW
RGD ID:6881948
Promoter ID:EPDNEW_M4425
Type:multiple initiation site
Name:Tmigd3_2
Description:Mus musculus transmembrane and immunoglobulin domain containing3 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4422  EPDNEW_M4423  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383105,914,142 - 105,914,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:5604098 AgrOrtholog
Ensembl Genes ENSMUSG00000000562 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSG00000074344 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUSG00000118531 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010279 ENTREZGENE
  ENSMUST00000010279.10 UniProtKB/Swiss-Prot
  ENSMUST00000164730 ENTREZGENE
  ENSMUST00000164730.2 UniProtKB/TrEMBL
  ENSMUST00000196748.2 UniProtKB/TrEMBL
  ENSMUST00000198080.5 UniProtKB/Swiss-Prot
  ENSMUST00000199977.2 UniProtKB/TrEMBL
  ENSMUST00000200482.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Adeno_A3_rcpt UniProtKB/TrEMBL
  Adenosn_rcpt UniProtKB/TrEMBL
  CD300_family_receptors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69296 UniProtKB/Swiss-Prot
MGD MGI:5604098 ENTREZGENE
NCBI Gene 1700001D09Rik ENTREZGENE
PANTHER ADENOSINE RECEPTOR A3 UniProtKB/TrEMBL
  OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR UniProtKB/TrEMBL
  POLYMERIC-IMMUNOGLOBULIN RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN TMIGD3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Tmigd3 PhenoGen
PRINTS ADENOSINEA3R UniProtKB/TrEMBL
  ADENOSINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JE84 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JEA6_MOUSE UniProtKB/TrEMBL
  A0A0G2JGS1_MOUSE UniProtKB/TrEMBL
  G3X8R9 ENTREZGENE
  Q497R5 ENTREZGENE, UniProtKB/TrEMBL
  Q9DAR9 ENTREZGENE
  TMIG3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9DAR9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-18 Tmigd3  transmembrane and immunoglobulin domain containing 3  1700001D09Rik  RIKEN cDNA 1700001D09 gene  Symbol and/or name change 5135510 APPROVED