Brcc3dc (BRCA1/BRCA2-containing complex, subunit 3, domain containing) - Rat Genome Database

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Gene: Brcc3dc (BRCA1/BRCA2-containing complex, subunit 3, domain containing) Rattus norvegicus
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Symbol: Brcc3dc
Name: BRCA1/BRCA2-containing complex, subunit 3, domain containing
RGD ID: 9447173
Description: Predicted to enable metal ion binding activity; peptidase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and response to ionizing radiation. Predicted to be located in cytoplasm and spindle pole. Predicted to be part of BRCA1-A complex and BRISC complex.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC103692848; lys-63-specific deubiquitinase BRCC36-like
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8745,901,321 - 45,903,078 (-)NCBIGRCr8
mRatBN7.2744,014,889 - 44,016,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl744,005,646 - 44,016,670 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0750,284,406 - 50,291,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera740,877,276 - 40,884,807 (-)NCBICelera
Cytogenetic Map7q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
Brcc3dc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8745,901,321 - 45,903,078 (-)NCBIGRCr8
mRatBN7.2744,014,889 - 44,016,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl744,005,646 - 44,016,670 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0750,284,406 - 50,291,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera740,877,276 - 40,884,807 (-)NCBICelera
Cytogenetic Map7q21NCBI
Brcc3dc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910108,534,905 - 108,536,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10108,534,625 - 108,536,021 (-)EnsemblGRCm39 Ensembl
GRCm3810108,699,044 - 108,700,160 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10108,698,764 - 108,700,160 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710108,136,100 - 108,137,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610108,103,327 - 108,104,202 (-)NCBIMGSCv36mm8
Celera10110,644,578 - 110,645,694 (-)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1056.63NCBI

Variants

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Variants in Brcc3dc
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000107516   ⟹   ENSRNOP00000091059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl744,005,646 - 44,016,670 (-)Ensembl
RefSeq Acc Id: NM_001409064   ⟹   NP_001395993
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,901,321 - 45,903,078 (-)NCBI
mRatBN7.2744,014,889 - 44,016,646 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001395993 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091059
  ENSRNOP00000091059.1
RefSeq Acc Id: ENSRNOP00000091059   ⟸   ENSRNOT00000107516
RefSeq Acc Id: NP_001395993   ⟸   NM_001409064
- UniProtKB: A0A8I6AEX4 (UniProtKB/TrEMBL)
Protein Domains
MPN

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-34154 BioCyc
Ensembl Genes ENSRNOG00000070196 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000107516 ENTREZGENE
  ENSRNOT00000107516.1 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
InterPro BRCC36_C UniProtKB/TrEMBL
  JAMM/MPN+_dom UniProtKB/TrEMBL
  MPN UniProtKB/TrEMBL
  MPN_BRCC36 UniProtKB/TrEMBL
KEGG Report rno:103692848 UniProtKB/TrEMBL
NCBI Gene LOC103692848 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED UniProtKB/TrEMBL
  LYS-63-SPECIFIC DEUBIQUITINASE BRCC36-LIKE UniProtKB/TrEMBL
Pfam BRCC36_C UniProtKB/TrEMBL
  JAB UniProtKB/TrEMBL
PhenoGen Brcc3dc PhenoGen
PROSITE MPN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000070196 RatGTEx
SMART JAB_MPN UniProtKB/TrEMBL
Superfamily-SCOP JAB1/MPN domain UniProtKB/TrEMBL
UniProt A0A8I6AEX4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-08 Brcc3dc  BRCA1/BRCA2-containing complex, subunit 3, domain containing  LOC103692848  lys-63-specific deubiquitinase BRCC36-like  Name and Symbol changed 629549 APPROVED
2014-08-25 LOC103692848  lys-63-specific deubiquitinase BRCC36-like      Symbol and Name status set to provisional 70820 PROVISIONAL