Cd244 (CD244 molecule) - Rat Genome Database

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Gene: Cd244 (CD244 molecule) Rattus norvegicus
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Symbol: Cd244
Name: CD244 molecule
RGD ID: 9330179
Description: Predicted to enable MHC class I protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including natural killer cell activation involved in immune response; positive regulation of biosynthetic process; and positive regulation of lymphocyte proliferation. Predicted to act upstream of or within natural killer cell activation. Predicted to be located in external side of plasma membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human CD244 (CD244 molecule); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103692282; natural killer cell receptor 2B4; natural killer cell receptor 2B4-like; NK cell receptor 2B4; uncharacterized LOC103692282
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,583,727 - 86,606,902 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,584,826 - 86,616,009 (+)EnsemblGRCr8
mRatBN7.21384,051,339 - 84,082,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,052,493 - 84,074,492 (+)EnsemblmRatBN7.2
Rnor_6.01389,997,710 - 90,004,364 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Celera1383,706,022 - 83,712,677 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11275258  


Genomics

Comparative Map Data
Cd244
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,583,727 - 86,606,902 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,584,826 - 86,616,009 (+)EnsemblGRCr8
mRatBN7.21384,051,339 - 84,082,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,052,493 - 84,074,492 (+)EnsemblmRatBN7.2
Rnor_6.01389,997,710 - 90,004,364 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Celera1383,706,022 - 83,712,677 (+)NCBICelera
Cytogenetic Map13q24NCBI
CD244
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,830,160 - 160,862,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,830,160 - 160,862,887 (-)Ensemblhg38GRCh38
GRCh371160,799,950 - 160,832,677 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,066,574 - 159,099,269 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341157,613,023 - 157,645,718NCBI
Celera1133,868,617 - 133,900,871 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,156,082 - 132,188,997 (-)NCBIHuRef
CHM1_11162,195,333 - 162,228,071 (-)NCBICHM1_1
T2T-CHM13v2.01159,967,199 - 159,999,910 (-)NCBIT2T-CHM13v2.0
Cd244a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,386,761 - 171,412,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,386,761 - 171,437,314 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381171,558,718 - 171,585,316 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,559,193 - 171,609,746 (+)Ensemblmm10GRCm38
MGSCv371173,489,324 - 173,515,447 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361173,395,874 - 173,420,233 (+)NCBIMGSCv36mm8
MGSCv361172,839,241 - 172,863,626 (+)NCBIMGSCv36mm8
Celera1174,415,055 - 174,442,954 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.52NCBI

Variants

.
Variants in Cd244
483 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
14 1 33 94 134 260 186 21 92 60 64 24 24

Sequence


Ensembl Acc Id: ENSRNOT00000006266   ⟹   ENSRNOP00000006266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,584,826 - 86,616,009 (+)Ensembl
mRatBN7.2 Ensembl1384,052,493 - 84,074,492 (+)Ensembl
RefSeq Acc Id: NM_001419604   ⟹   NP_001406533
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,584,903 - 86,606,902 (+)NCBI
RefSeq Acc Id: XM_039091416   ⟹   XP_038947344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,584,053 - 86,606,902 (+)NCBI
mRatBN7.21384,052,009 - 84,075,700 (+)NCBI
RefSeq Acc Id: XM_039091417   ⟹   XP_038947345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,584,053 - 86,606,902 (+)NCBI
mRatBN7.21384,052,009 - 84,075,700 (+)NCBI
RefSeq Acc Id: XM_039091419   ⟹   XP_038947347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,583,727 - 86,601,703 (+)NCBI
mRatBN7.21384,051,339 - 84,069,293 (+)NCBI
RefSeq Acc Id: XM_039091420   ⟹   XP_038947348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,583,727 - 86,600,982 (+)NCBI
mRatBN7.21384,051,339 - 84,068,676 (+)NCBI
RefSeq Acc Id: XM_039091423   ⟹   XP_038947351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,584,056 - 86,606,902 (+)NCBI
mRatBN7.21384,052,011 - 84,075,700 (+)NCBI
RefSeq Acc Id: XP_038947347   ⟸   XM_039091419
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038947348   ⟸   XM_039091420
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038947344   ⟸   XM_039091416
- Peptide Label: isoform X1
- UniProtKB: Q9EQK9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947345   ⟸   XM_039091417
- Peptide Label: isoform X2
- UniProtKB: Q9EQK9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947351   ⟸   XM_039091423
- Peptide Label: isoform X5
- UniProtKB: A6JG03 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000006266   ⟸   ENSRNOT00000006266
RefSeq Acc Id: NP_001406533   ⟸   NM_001419604
- Peptide Label: precursor
- UniProtKB: E9PT21 (UniProtKB/TrEMBL),   Q9EQK9 (UniProtKB/TrEMBL)
Protein Domains
Natural killer cell receptor 2B4 immunoglobulin

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:9330179 AgrOrtholog
BioCyc Gene G2FUF-17357 BioCyc
Ensembl Genes ENSRNOG00000064255 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006266 ENTREZGENE
  ENSRNOT00000006266.8 UniProtKB/TrEMBL
Gene3D-CATH Immunoglobulins UniProtKB/TrEMBL
InterPro CD2/SLAM_rcpt UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  NK_rcpt_2B4_Ig_dom UniProtKB/TrEMBL
NCBI Gene LOC103692282 ENTREZGENE
PANTHER NATURAL KILLER CELL RECEPTOR 2B4 UniProtKB/TrEMBL
  SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE UniProtKB/TrEMBL
Pfam Receptor_2B4 UniProtKB/TrEMBL
PhenoGen Cd244 PhenoGen
RatGTEx ENSRNOG00000064255 RatGTEx
RNAcentral URS0000CCE181 RNACentral
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL
UniProt A6JG03 ENTREZGENE, UniProtKB/TrEMBL
  E9PT21 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQK9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-11 Cd244  CD244 molecule  LOC103692282  uncharacterized LOC103692282  Name and Symbol changed 629549 APPROVED
2014-08-25 LOC103692282  uncharacterized LOC103692282      Symbol and Name status set to provisional 70820 PROVISIONAL