Spen (spen family transcriptional repressor) - Rat Genome Database
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Gene: Spen (spen family transcriptional repressor) Chinchilla lanigera
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Symbol: Spen
Name: spen family transcriptional repressor
RGD ID: 9057405
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); RNA polymerase II transcription factor binding (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); negative regulation of transcription, DNA-templated (ortholog); positive regulation of neurogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH breast ductal carcinoma (ortholog); Prostatic Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription repressor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: spen homolog, transcriptional regulator
Orthologs:
Homo sapiens (human) : SPEN (spen family transcriptional repressor)  HGNC  Alliance
Mus musculus (house mouse) : Spen (spen family transcription repressor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spen (spen family transcriptional repressor)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : SPEN (spen family transcriptional repressor)
Canis lupus familiaris (dog) : SPEN (spen family transcriptional repressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spen (spen family transcriptional repressor)
Sus scrofa (pig) : SPEN (spen family transcriptional repressor)
Chlorocebus sabaeus (African green monkey) : SPEN (spen family transcriptional repressor)
Heterocephalus glaber (naked mole-rat) : Spen (spen family transcriptional repressor)
more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,280,459 - 2,343,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,279,438 - 2,343,263 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Spen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,280,459 - 2,343,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,279,438 - 2,343,263 (-)NCBIChiLan1.0ChiLan1.0
SPEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl115,836,095 - 15,940,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl115,847,707 - 15,940,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38115,847,707 - 15,940,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,174,359 - 16,266,951 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,046,946 - 16,139,537 (+)NCBINCBI36hg18NCBI36
Build 34115,919,664 - 16,012,256NCBI
Celera114,654,230 - 14,746,824 (+)NCBI
Cytogenetic Map1p36.21-p36.13NCBI
HuRef114,692,961 - 14,785,958 (+)NCBIHuRef
CHM1_1115,972,883 - 16,065,485 (+)NCBICHM1_1
Spen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,195,199 - 141,265,955 (-)NCBI
GRCm384141,467,885 - 141,538,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,467,890 - 141,538,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,023,805 - 141,094,512 (-)NCBIGRCm37mm9NCBIm37
MGSCv364140,740,934 - 140,794,407 (-)NCBImm8
Celera4143,285,155 - 143,361,424 (-)NCBICelera
Cytogenetic Map4D3NCBI
Spen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05160,015,573 - 160,070,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,735,389 - 163,790,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,359,738 - 160,414,311 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5152,134,833 - 152,205,318 (-)NCBICelera
Cytogenetic Map5q36NCBI
SPEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,004,908 - 16,072,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,004,473 - 16,072,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0114,987,415 - 15,079,477 (+)NCBIMhudiblu_PPA_v0panPan3
SPEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,683,824 - 81,775,904 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Spen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364743,473,892 - 3,535,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,015,521 - 75,107,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,015,565 - 75,107,468 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPEN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl20116,361,008 - 116,458,064 (-)Ensembl
ChlSab1.120116,359,981 - 116,458,156 (-)NCBI
Spen
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247642,058,689 - 2,144,640 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000002856   ⟹   ENSCLAP00000002800
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555272,280,459 - 2,343,262 (-)Ensembl
RefSeq Acc Id: XM_013507394   ⟹   XP_013362848
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555272,279,438 - 2,343,263 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013362848 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013362848   ⟸   XM_013507394
- Sequence:
RefSeq Acc Id: ENSCLAP00000002800   ⟸   ENSCLAT00000002856


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002018 Ensembl
NCBI Gene Spen ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Spen  spen family transcriptional repressor    spen homolog, transcriptional regulator (Drosophila)  Symbol and/or name change 5135510 APPROVED