Sppl2b (signal peptide peptidase like 2B) - Rat Genome Database

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Gene: Sppl2b (signal peptide peptidase like 2B) Chinchilla lanigera
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Symbol: Sppl2b
Name: signal peptide peptidase like 2B
RGD ID: 9039068
Description: ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (ortholog); protein homodimerization activity (ortholog); INVOLVED IN membrane protein ectodomain proteolysis (ortholog); membrane protein intracellular domain proteolysis (ortholog); membrane protein proteolysis (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); progressive myoclonus epilepsy 9 (ortholog); FOUND IN actin cytoskeleton (ortholog); centrosome (ortholog); cytoplasmic side of endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: signal peptide peptidase-like 2B
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,818,337 - 5,829,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,816,979 - 5,829,938 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sppl2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,818,337 - 5,829,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,816,979 - 5,829,938 (-)NCBIChiLan1.0ChiLan1.0
SPPL2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,328,684 - 2,355,095 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,328,615 - 2,355,095 (+)EnsemblGRCh38hg38GRCh38
GRCh37192,328,683 - 2,355,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,279,629 - 2,306,100 (+)NCBINCBI36Build 36hg18NCBI36
Celera192,262,722 - 2,289,416 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,099,320 - 2,126,087 (+)NCBIHuRef
CHM1_1192,328,242 - 2,354,745 (+)NCBICHM1_1
T2T-CHM13v2.0192,302,357 - 2,328,755 (+)NCBIT2T-CHM13v2.0
Sppl2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,691,067 - 80,704,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,691,109 - 80,704,542 (+)EnsemblGRCm39 Ensembl
GRCm381080,855,242 - 80,868,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,855,275 - 80,868,708 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,318,020 - 80,331,453 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,258,386 - 80,271,834 (+)NCBIMGSCv36mm8
Celera1081,874,073 - 81,887,506 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Sppl2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,494,593 - 9,507,317 (-)NCBIGRCr8
mRatBN7.278,843,918 - 8,856,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,843,918 - 8,856,608 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,727,769 - 11,740,555 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,603,273 - 13,616,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,469,804 - 11,482,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,712,187 - 11,724,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,712,188 - 11,724,843 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,879,707 - 11,892,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,354,554 - 10,367,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,354,554 - 10,367,210 (-)NCBI
Celera77,028,038 - 7,040,694 (-)NCBICelera
Cytogenetic Map7q11NCBI
SPPL2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,711,728 - 6,736,722 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,941,082 - 5,968,189 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,337,570 - 1,355,755 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,309,360 - 2,331,951 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,309,360 - 2,331,951 (+)Ensemblpanpan1.1panPan2
SPPL2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,714,306 - 56,730,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,712,390 - 56,757,938 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,509,908 - 56,525,995 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,447,711 - 57,463,802 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,447,720 - 57,463,752 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,499,796 - 56,515,881 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,985,051 - 57,001,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,185,354 - 57,201,441 (-)NCBIUU_Cfam_GSD_1.0
Sppl2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,426,113 - 216,435,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,399,085 - 1,408,783 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,399,125 - 1,408,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPPL2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,230,061 - 76,247,051 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,230,060 - 76,247,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,781,961 - 76,798,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPPL2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,121,568 - 2,142,746 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,121,634 - 2,144,682 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,566,507 - 6,588,105 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sppl2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,562,426 - 6,576,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,564,127 - 6,576,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000014871   ⟹   ENSCLAP00000014712
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554955,818,337 - 5,829,889 (-)Ensembl
RefSeq Acc Id: XM_005405903   ⟹   XP_005405960
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554955,816,979 - 5,829,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005405904   ⟹   XP_005405961
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554955,816,979 - 5,829,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505229   ⟹   XP_013360683
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554955,818,518 - 5,829,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505231   ⟹   XP_013360685
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554955,818,532 - 5,829,938 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005405960 (Get FASTA)   NCBI Sequence Viewer  
  XP_005405961 (Get FASTA)   NCBI Sequence Viewer  
  XP_013360683 (Get FASTA)   NCBI Sequence Viewer  
  XP_013360685 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000014712
  ENSCLAP00000014712.1
RefSeq Acc Id: XP_005405961   ⟸   XM_005405904
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VF76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005405960   ⟸   XM_005405903
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VF76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013360683   ⟸   XM_013505229
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VF76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013360685   ⟸   XM_013505231
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VF76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000014712   ⟸   ENSCLAT00000014871
Protein Domains
PA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010153 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014871 ENTREZGENE
  ENSCLAT00000014871.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.30.30 UniProtKB/TrEMBL
InterPro PA_dom_sf UniProtKB/TrEMBL
  PA_domain UniProtKB/TrEMBL
  Peptidase_A22B_SPP UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/TrEMBL
NCBI Gene Sppl2b ENTREZGENE
PANTHER PTHR12174 UniProtKB/TrEMBL
  PTHR12174:SF39 UniProtKB/TrEMBL
Pfam Peptidase_A22B UniProtKB/TrEMBL
  PF02225 UniProtKB/TrEMBL
SMART PSN UniProtKB/TrEMBL
Superfamily-SCOP PA domain UniProtKB/TrEMBL
UniProt A0A8C2VF76 ENTREZGENE, UniProtKB/TrEMBL