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Gene: C1qa (complement C1q A chain) Chinchilla lanigera

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Symbol:

C1qa

Name:

complement C1q A chain

RGD ID:

9017677

Description:

INVOLVED IN astrocyte activation (ortholog); complement activation, classical pathway (ortholog); complement-mediated synapse pruning (ortholog); ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); basal cell carcinoma (ortholog); Brain Injuries (ortholog); FOUND IN complement component C1q complex (ortholog); extracellular region (ortholog); extrinsic component of postsynaptic membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

complement C1q subcomponent subunit A; complement component 1, q subcomponent, A chain

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	2,752,970 - 2,756,488 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	2,753,362 - 2,756,220 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ISO)

basal cell carcinoma (ISO)

Brain Injuries (ISO)

C1q Deficiency (ISO)

C1q Deficiency 1 (ISO)

congenital disorder of glycosylation Ir (ISO)

COVID-19 (ISO)

Drug Hypersensitivity Syndrome (ISO)

epilepsy (ISO)

exanthem (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

glomerulonephritis (ISO)

hyperprolinemia type 2 (ISO)

hypersensitivity reaction type III disease (ISO)

IgA glomerulonephritis (ISO)

iron deficiency anemia (ISO)

membranoproliferative glomerulonephritis (ISO)

Parkinson's disease 6 (ISO)

Stevens-Johnson syndrome (ISO)

systemic lupus erythematosus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

astrocyte activation (ISO)

complement activation, classical pathway (ISO)

complement-mediated synapse pruning (ISO)

microglial cell activation (ISO)

neuron remodeling (ISO)

response to iron ion (ISO)

synapse organization (ISO)

synapse pruning (ISO)

vertebrate eye-specific patterning (ISO)

Cellular Component

complement component C1q complex (ISO)

extracellular region (ISO)

extrinsic component of postsynaptic membrane (ISO)

extrinsic component of presynaptic membrane (ISO)

glutamatergic synapse (ISO)

postsynapse (ISO)

synapse (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

C1qa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	2,752,970 - 2,756,488 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	2,753,362 - 2,756,220 (+)	NCBI	ChiLan1.0	ChiLan1.0

C1QA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	22,636,463 - 22,639,678 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	22,635,077 - 22,639,678 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	22,962,956 - 22,966,171 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	22,835,705 - 22,838,762 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	22,709,405 - 22,711,405	NCBI
Celera	1	21,287,826 - 21,290,883 (+)	NCBI		Celera
Cytogenetic Map	1	p36.12	NCBI
HuRef	1	21,207,463 - 21,210,520 (+)	NCBI		HuRef
CHM1_1	1	23,075,637 - 23,078,694 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	22,461,488 - 22,464,703 (+)	NCBI		T2T-CHM13v2.0

C1qa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	136,623,227 - 136,626,155 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	136,623,228 - 136,626,114 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	136,895,916 - 136,898,844 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	136,895,917 - 136,898,803 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	136,451,831 - 136,454,759 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	136,167,994 - 136,170,836 (-)	NCBI		MGSCv36	mm8
Celera	4	135,103,233 - 135,106,157 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	69.05	NCBI

C1qa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	154,417,086 - 154,419,933 (-)	NCBI		GRCr8
mRatBN7.2	5	149,133,635 - 149,136,482 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	149,133,636 - 149,136,534 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	151,831,406 - 151,834,253 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	153,605,693 - 153,608,540 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	153,587,691 - 153,590,538 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	155,261,254 - 155,264,101 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	155,261,250 - 155,264,143 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	159,023,753 - 159,026,600 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	155,662,333 - 155,665,180 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	155,672,371 - 155,675,219 (-)	NCBI
Celera	5	147,531,382 - 147,534,229 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

C1QA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	76,668,086 - 76,671,082 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	76,668,217 - 76,670,977 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	73,172,967 - 73,175,970 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	77,227,331 - 77,230,335 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	77,227,333 - 77,230,230 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	74,048,204 - 74,051,200 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	75,056,639 - 75,059,641 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	76,060,247 - 76,063,252 (-)	NCBI		UU_Cfam_GSD_1.0

C1qa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	42,183,130 - 42,185,545 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	8,008,534 - 8,010,191 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	8,007,953 - 8,010,591 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C1QA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	80,586,280 - 80,589,204 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	80,586,259 - 80,589,213 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	74,610,025 - 74,612,855 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

C1QA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	110,024,847 - 110,027,868 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	6,286,037 - 6,289,144 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C1qa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	7,363,567 - 7,366,617 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	7,363,615 - 7,366,408 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013519754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01043903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01006456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000013548 ⟹ ENSCLAP00000013395

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955452	2,752,970 - 2,756,488 (+)	Ensembl

RefSeq Acc Id:

XM_013519754 ⟹ XP_013375208

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955452	2,753,362 - 2,756,220 (+)	NCBI

Sequence:

show sequence

GAAAGTTCCGTGGGTGAGTTCTGTTCCGGGGGCCCAAGCACAGAAGAGGAAGGACAAGCGGGAA
GGGATGTGAAACTTGGCCTGGCCACAGCTGCAGCACCCCCGCTGGGCTTCCCACCCGGCTCCCC
AGGCCGAGGACGGGAGCATCCAGTTGGAGTGGACACCGGACGCAGGGACATCATGTCTCCCGGG
GGATGGCTGGTTGTCTGCATGCTGGCTGTATCCCTGGCCTCTACGGTGACCGAGGATGTGTGTC
GAGCACCCAATGGGAAAGATGGGGTTGCAGGAAAACCAGGACGACCCGGGAGGTCTGGCCTCAA
GGGGGAGCGGGGAGAGCCAGGAGCCCCTGGCATCCGGACAGGCATCCGAGGCCCTAAAGGAGAC
CAGGGGGAGCCCGGGCCTCCTGGGAGACCAGGCAATGTGGGCTACCCAGGGCCCAGCGGCCTCC
CAGGGCTACCAGGTCCCTCAGGACCAAGGGGCACGAAGGGCAGTCCAGGCAACATCAGGGACCA
GCCGCGGCCAGCCTTCTCGGCCATTAGACGGAACCCCCCGCGGAGCACCAGCAATGTGGTGCTC
TTCGACGAGGTCATCACCAACCAGGAAGGGCCCTACAATAATAACACGGGCCAGTTCCTCTGCA
CCGTGCCCGGCTTCTACTACTTCACCTTCCAAATGGTCTCCACGGGCGACACCTGCCTGACCAT
CGTGTCCTCCTCCCACGGCCAGCGCCGCCAGTCCCCGGGCTTCTGCGACACCAGTAACAAAGGC
CTCTTCCAGATATCAGGGGGCACCTCGCTCCAGCTGCAGCAGGGCGACAAGGTTTGGATAGAGA
AGGATCCCTTTAAGGGAAACATCTACCAGGGCACTGAAGTCGACAGTATCTTCAGCGGCTTCCT
CATTTTCCCGTCTGTCTGAGCTGGGGGTTGCCTCCTGCCACTGCTGCCACTGCTCCTGCCACCG
CGCTGGCCTCCCCACTCCCCACCTGGGGCCCCAGCTCACTCCCCCTTCCTGGGATCCTCTGCTC
TACAAAATGGGGGGCTACTGCTCTAGCCACCTGAGTCCGGGATCTGGCTCCCATGTCTCTGGGA
CCGGGCACCAGGGCGCCCTCCGAGCACATCCTTACAGCCCTCCCTGGAATAAACGCCCACGTCT
CTAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_013375208	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000013395
	ENSCLAP00000013395.1

RefSeq Acc Id:

XP_013375208 ⟸ XM_013519754

- UniProtKB:

A0A8C2VCN4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSPGGWLVVCMLAVSLASTVTEDVCRAPNGKDGVAGKPGRPGRSGLKGERGEPGAPGIRTGIRG
PKGDQGEPGPPGRPGNVGYPGPSGLPGLPGPSGPRGTKGSPGNIRDQPRPAFSAIRRNPPRSTS
NVVLFDEVITNQEGPYNNNTGQFLCTVPGFYYFTFQMVSTGDTCLTIVSSSHGQRRQSPGFCDT
SNKGLFQISGGTSLQLQQGDKVWIEKDPFKGNIYQGTEVDSIFSGFLIFPSV

hide sequence

Ensembl Acc Id:

ENSCLAP00000013395 ⟸ ENSCLAT00000013548

Protein Domains

C1q

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009255	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000013548	ENTREZGENE
	ENSCLAT00000013548.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.40	UniProtKB/TrEMBL
InterPro	C1q_dom	UniProtKB/TrEMBL
	Collagen	UniProtKB/TrEMBL
	Collagen/C1q_domain	UniProtKB/TrEMBL
	Tumour_necrosis_fac-like_dom	UniProtKB/TrEMBL
NCBI Gene	C1qa	ENTREZGENE
PANTHER	EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER	UniProtKB/TrEMBL
	PTHR15427:SF26	UniProtKB/TrEMBL
Pfam	C1q	UniProtKB/TrEMBL
	Collagen	UniProtKB/TrEMBL
PRINTS	COMPLEMNTC1Q	UniProtKB/TrEMBL
PROSITE	C1Q	UniProtKB/TrEMBL
SMART	C1Q	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49842	UniProtKB/TrEMBL
UniProt	A0A8C2VCN4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-26	C1qa	complement C1q A chain		complement component 1, q subcomponent, A chain	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM