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Gene: Tcp1 (t-complex 1) Chinchilla lanigera

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Symbol:

Tcp1

Name:

t-complex 1

RGD ID:

9014150

Description:

ENCODES a protein that exhibits protein folding chaperone (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); chaperone-mediated protein folding (ortholog); positive regulation of establishment of protein localization to telomere (ortholog); ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH POLYMICROGYRIA AND SEIZURES (ortholog); Prostatic Neoplasms (ortholog); FOUND IN acrosomal vesicle (ortholog); cell body (ortholog); centrosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

T-complex protein 1 subunit alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TCP1 (t-complex 1)	NCBI	Ortholog
Mus musculus (house mouse):	Tcp1 (t-complex protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tcp1 (t-complex 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TCP1 (t-complex 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TCP1 (t-complex 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tcp1 (t-complex 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TCP1 (t-complex 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TCP1 (t-complex 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tcp1 (t-complex 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955439	21,114,038 - 21,124,379 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ISO)

INTELLECTUAL DEVELOPMENTAL DISORDER WITH POLYMICROGYRIA AND SEIZURES (ISO)

Prostatic Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

binding of sperm to zona pellucida (ISO)

chaperone-mediated protein folding (ISO)

positive regulation of establishment of protein localization to telomere (ISO)

positive regulation of protein localization to Cajal body (ISO)

positive regulation of telomerase RNA localization to Cajal body (ISO)

positive regulation of telomere maintenance via telomerase (ISO)

protein folding (ISO)

protein stabilization (ISO)

scaRNA localization to Cajal body (ISO)

Cellular Component

acrosomal vesicle (ISO)

cell body (ISO)

centrosome (ISO)

chaperonin-containing T-complex (ISO)

Golgi apparatus (ISO)

heterochromatin (ISO)

microtubule (ISO)

microtubule organizing center (ISO)

pericentriolar material (ISO)

zona pellucida receptor complex (ISO)

Molecular Function

protein binding (ISO)

protein folding chaperone (ISO)

ubiquitin protein ligase binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Tcp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955439	21,114,038 - 21,124,379 (+)	NCBI	ChiLan1.0	ChiLan1.0

TCP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	159,778,498 - 159,789,602 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	159,778,498 - 159,789,703 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	160,199,530 - 160,210,634 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	160,119,520 - 160,130,725 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	160,169,941 - 160,181,146	NCBI
Celera	6	160,845,607 - 160,856,819 (-)	NCBI		Celera
Cytogenetic Map	6	q25.3	NCBI
HuRef	6	157,669,773 - 157,680,978 (-)	NCBI		HuRef
CHM1_1	6	160,461,821 - 160,473,042 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	161,024,115 - 161,035,234 (-)	NCBI		T2T-CHM13v2.0

Tcp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	13,135,216 - 13,143,954 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	13,134,588 - 13,143,954 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	12,916,329 - 12,925,067 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	12,915,701 - 12,925,067 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	13,109,331 - 13,117,933 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	12,759,446 - 12,767,497 (+)	NCBI		MGSCv36	mm8
Celera	17	12,948,013 - 12,956,616 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	8.72	NCBI

Tcp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	50,376,848 - 50,384,527 (-)	NCBI		GRCr8
mRatBN7.2	1	47,829,061 - 47,836,809 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	47,828,652 - 47,836,839 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	48,520,703 - 48,528,382 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	54,506,599 - 54,514,346 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	48,596,232 - 48,603,911 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	48,025,664 - 48,033,343 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	48,025,663 - 48,033,396 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	51,719,055 - 51,726,734 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	42,103,543 - 42,111,222 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	42,106,487 - 42,114,167 (-)	NCBI
Celera	1	43,629,524 - 43,637,203 (-)	NCBI		Celera
RH 3.4 Map	1	537.31	RGD
Cytogenetic Map	1	q11	NCBI

TCP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	179,877,363 - 179,888,668 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	177,781,864 - 177,793,622 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	157,661,409 - 157,672,581 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	162,673,050 - 162,684,261 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	162,673,596 - 162,683,985 (-)	Ensembl	panpan1.1		panPan2

TCP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	49,029,260 - 49,038,023 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	49,029,282 - 49,038,020 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	49,871,249 - 49,879,992 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	49,213,974 - 49,222,681 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	49,213,961 - 49,222,697 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	49,096,311 - 49,105,058 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	48,967,408 - 48,976,160 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	49,582,581 - 49,591,336 (-)	NCBI		UU_Cfam_GSD_1.0

Tcp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	144,021,338 - 144,030,784 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936489	11,273,335 - 11,282,811 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TCP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	7,590,140 - 7,601,795 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	7,590,140 - 7,600,709 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	9,389,098 - 9,399,667 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TCP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	87,377,452 - 87,388,692 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	87,377,996 - 87,388,568 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	59,776,464 - 59,787,759 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tcp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624855	3,121,274 - 3,133,640 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013517327	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01036138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01036139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01036140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01002217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01010602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_013517327 ⟹ XP_013372781

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955439	21,114,038 - 21,124,379 (+)	NCBI

Sequence:

show sequence

GGAGGGGAGGGGTTGGGCGGGCGCGGTGTTACCCAGCTGCCCCTGGGCGGCGCTCGGGCCCGTC
CGTCGCCGCTCTCCGGCCTGCTTCCAGGGACTGCTGGCGGGCGCGCCAGGAAGATGGAGGGCCC
TTTGTCCGTGCTGGGGGACCGCAGCACCGGGGAGGCGATCCGCTCGCAGAACGTTATGGCTGCC
GCCTCTATTGCGAATATCGTAAAAAGTTCTCTTGGTCCGGTTGGCTTGGATAAAATGTTGGTGG
ACGATATTGGTGATGTAACCATTACTAATGATGGTGCCACCATCCTGAAGTTACTGGAGGTAGA
ACATCCTGCAGCTAAAGTTCTTTGTGAGCTGGCTGATCTGCAAGACAGAGAAGTTGGAGATGGA
ACAACCTCAGTGGTTATCATTGCCGCAGAACTTCTGAAAAATGCAGATGAACTTGTGAAACAGA
AAATTCATCCCACATCAGTTATTAGTGGCTATCGACTTGCTTGCAAGGAAGCAGTGCGCTATAT
CAGTGAAAACCTAATTATTAACACAGACGAACTTGGAAGGGATTGCCTGATTAATGCTGCTAAG
ACATCCATGTCTTCCAAAATTATTGGAGTAAATGGGGATTTCTTTTCCAATATGGTAGTAGATG
CGGTACTTGCTGTTAAATATACGGATGGAAGAGGCCAGCCTCACTACCCAGTCAATTCTGTGAA
TATTCTGAAAGCCCACGGGAGAAGTCAGACAGAAAGCATGCTGGTCAGTGGCTATGCACTCAAC
TGTGTGGTGGCGTCTCAGGGCTTGCCCAAGAGACTAGTTAATGCAAAAATTGCTTGCCTTGACT
TCAGCCTGCAGAAAGCAAAAATGAAGCTTGGGGTACAGGTGGTTATTACAGACCCTGAGAAACT
GGACCAAATTAGACAGAGAGAATCAGACATCACGAAAGAGAGAATTCAGAAGATCCTGGCAACT
GGGGCCAATGTGATTCTAACCACCGGTGGTATTGATGACATGTGTCTGAAGTATTTCGTGGAGG
CAGGTGCCATGGCCGTTAGAAGAGTCTTAAAAAGGGACCTTAAACGCATCGCTAAAGCTTCTGG
AGCGACTGTTCTGTCAACACTGGCCAATTTGGAAGGAGAAGAAACTTTTGAAGCTACAATGTTG
GGACAAGCAGAAGAGGTGGTACAGGAGAGAATCTGTGACGATGAACTGATCTTAATCAAAAATA
CGAAGGCTCGCACATCTGCATCGATTATCCTACGTGGGGCCAATGATTTCATGTGTGACGAGAT
GGAGCGCTCTCTACATGACGCACTTTGCGTGGTGAAGAGAGTTTTGGAGTCAAAATCTGTGGTT
CCCGGTGGGGGTGCAGTGGAAGCCGCCCTTTCCATATACCTTGAGAACTACGCCACCAGCATGG
GGTCTCGGGAACAGCTTGCTATTGCGGAGTTTGCAAGATCTCTTCTCGTCATTCCCAACACACT
GGCGGTGAACGCTGCCCAGGACTCTACAGATCTGGTTGCAAAGTTAAGGGCTTTTCATAATGAG
GCTCAGGTTAACCCAGAGCGTAAAAATCTAAAATGGATTGGTCTTGATTTGATCAATGGTAAAC
CGAGAGACAACAAACAAGCAGGGGTGTTTGAACCGACCATAGTTAAAGTAAAGAGCTTGAAATT
TGCAACAGAAGCTGCAATTACCATTCTCCGAATTGATGACCTGATTAAATTACACCCAGAAGGC
AAAGATGATAAGCATGGCGGTTATGAAGACGCTGTTCATTCTGGAGCCCTTAACGACTGATGTG
ATTTCTGTTTAATTTAATTTATAATACTTTTGGATGGAATGTCTTGTGGCTTGAGTATTACACA
TTAAAGTACAGCAAGCTGACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013372781	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000003713.1

RefSeq Acc Id:

XP_013372781 ⟸ XM_013517327

- UniProtKB:

A0A8C2URN3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGPLSVLGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKL
LEVEHPAAKVLCELADLQDREVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEA
VRYISENLIINTDELGRDCLINAAKTSMSSKIIGVNGDFFSNMVVDAVLAVKYTDGRGQPHYPV
NSVNILKAHGRSQTESMLVSGYALNCVVASQGLPKRLVNAKIACLDFSLQKAKMKLGVQVVITD
PEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIA
KASGATVLSTLANLEGEETFEATMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFM
CDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVI
PNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLINGKPRDNKQAGVFEPTIVKVK
SLKFATEAAITILRIDDLIKLHPEGKDDKHGGYEDAVHSGALND

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002649	UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000003789.1	UniProtKB/TrEMBL
Gene3D-CATH	GroEL	UniProtKB/TrEMBL
	GroEL-like equatorial domain	UniProtKB/TrEMBL
	TCP-1-like chaperonin intermediate domain	UniProtKB/TrEMBL
InterPro	Chap_CCT_alpha	UniProtKB/TrEMBL
	Chaperone_TCP-1	UniProtKB/TrEMBL
	Chaperonin_TCP-1_CS	UniProtKB/TrEMBL
	Cpn60/GroEL/TCP-1	UniProtKB/TrEMBL
	GroEL-like_apical_dom_sf	UniProtKB/TrEMBL
	GROEL-like_equatorial_sf	UniProtKB/TrEMBL
	TCP-1-like_intermed_sf	UniProtKB/TrEMBL
NCBI Gene	Tcp1	ENTREZGENE
PANTHER	CHAPERONIN	UniProtKB/TrEMBL
Pfam	Cpn60_TCP1	UniProtKB/TrEMBL
PRINTS	TCOMPLEXTCP1	UniProtKB/TrEMBL
PROSITE	TCP1_1	UniProtKB/TrEMBL
Superfamily-SCOP	GroEL apical domain-like	UniProtKB/TrEMBL
	GroEL equatorial domain-like	UniProtKB/TrEMBL
	GroEL-intermediate domain like	UniProtKB/TrEMBL
UniProt	A0A8C2URN3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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