Hhex (hematopoietically expressed homeobox) - Rat Genome Database

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Gene: Hhex (hematopoietically expressed homeobox) Chinchilla lanigera
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Symbol: Hhex
Name: hematopoietically expressed homeobox
RGD ID: 8999558
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding, bending (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); polycystic liver disease (ortholog); polycystic liver disease 1 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hematopoietically-expressed homeobox protein HHEX
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425735,378 - 742,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955425737,506 - 742,775 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
B cell differentiation  (ISO)
cell differentiation  (ISO)
common bile duct development  (ISO)
DNA conformation change  (ISO)
embryonic heart tube development  (ISO)
embryonic organ development  (ISO)
endoderm development  (ISO)
forebrain development  (ISO)
forebrain morphogenesis  (ISO)
gallbladder development  (ISO)
hemopoiesis  (ISO)
hepatic duct development  (ISO)
hepatoblast differentiation  (ISO)
hepatocyte differentiation  (ISO)
in utero embryonic development  (ISO)
interkinetic nuclear migration  (ISO)
liver development  (ISO)
morphogenesis of an epithelium  (ISO)
mRNA export from nucleus  (ISO)
multicellular organism growth  (ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
Notch signaling pathway  (ISO)
pancreas development  (ISO)
poly(A)+ mRNA export from nucleus  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
primary lung bud formation  (ISO)
primitive streak formation  (ISO)
protein localization to nucleus  (ISO)
regulation of cell population proliferation  (ISO)
regulation of leukocyte proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to peptide hormone  (ISO)
signal transduction  (ISO)
thyroid gland development  (ISO)
tissue morphogenesis  (ISO)
vasculogenesis  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hhex
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425735,378 - 742,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955425737,506 - 742,775 (-)NCBIChiLan1.0ChiLan1.0
HHEX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,689,955 - 92,695,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,689,955 - 92,695,647 (+)EnsemblGRCh38hg38GRCh38
GRCh371094,449,712 - 94,455,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,439,661 - 94,445,388 (+)NCBINCBI36Build 36hg18NCBI36
Build 341094,439,691 - 94,445,383NCBI
Celera1088,191,085 - 88,196,812 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,076,253 - 88,081,980 (+)NCBIHuRef
CHM1_11094,732,137 - 94,737,863 (+)NCBICHM1_1
T2T-CHM13v2.01093,569,602 - 93,575,294 (+)NCBIT2T-CHM13v2.0
Hhex
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,423,289 - 37,429,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,423,258 - 37,429,179 (+)EnsemblGRCm39 Ensembl
GRCm381937,434,841 - 37,440,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,434,810 - 37,440,731 (+)EnsemblGRCm38mm10GRCm38
MGSCv371937,509,331 - 37,515,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,499,985 - 37,505,875 (+)NCBIMGSCv36mm8
Celera1938,221,629 - 38,227,525 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.28NCBI
Hhex
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,602,945 - 244,608,532 (+)NCBIGRCr8
mRatBN7.21235,190,455 - 235,196,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,190,455 - 235,196,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,576,013 - 243,581,585 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,507,808 - 250,513,395 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,345,997 - 243,351,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,101,994 - 256,107,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,101,903 - 256,107,649 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,583,988 - 263,589,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,736,542 - 241,742,129 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,926,133 - 241,931,721 (+)NCBI
Celera1232,281,249 - 232,286,836 (+)NCBICelera
Cytogenetic Map1q53NCBI
HHEX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28104,725,043 - 104,730,830 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110104,730,394 - 104,736,144 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,433,402 - 89,439,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,947,373 - 92,952,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,947,373 - 92,952,992 (+)Ensemblpanpan1.1panPan2
HHEX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,057,379 - 7,063,326 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,057,283 - 7,063,330 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,233,996 - 7,239,896 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,317,251 - 7,323,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,317,203 - 7,323,145 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,037,744 - 7,043,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,072,416 - 7,078,310 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,236,847 - 7,242,744 (+)NCBIUU_Cfam_GSD_1.0
Hhex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,504,266 - 40,511,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,136,873 - 2,143,857 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,137,490 - 2,143,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHEX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14104,194,343 - 104,200,219 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114104,194,424 - 104,199,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,794,343 - 113,799,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HHEX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,957,684 - 85,963,414 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,957,779 - 85,963,404 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,697,779 - 46,703,530 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hhex
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,897,871 - 3,904,083 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,897,907 - 3,903,828 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000017849   ⟹   ENSCLAP00000017674
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955425735,378 - 742,775 (-)Ensembl
RefSeq Acc Id: XM_005386084   ⟹   XP_005386141
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955425737,506 - 742,775 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005386141 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017674
  ENSCLAP00000017674.1
RefSeq Acc Id: XP_005386141   ⟸   XM_005386084
- UniProtKB: A0A8C2VU13 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000017674   ⟸   ENSCLAT00000017849
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012119 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017849 ENTREZGENE
  ENSCLAT00000017849.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_DNA-bind_prot UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
NCBI Gene Hhex ENTREZGENE
PANTHER HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX UniProtKB/TrEMBL
  HOMEOBOX PROTEIN HHEX UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C2VU13 ENTREZGENE, UniProtKB/TrEMBL