Grk3 (G protein-coupled receptor kinase 3) - Rat Genome Database

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Gene: Grk3 (G protein-coupled receptor kinase 3) Chinchilla lanigera
Analyze
Symbol: Grk3
Name: G protein-coupled receptor kinase 3
RGD ID: 8998347
Description: ENCODES a protein that exhibits beta-adrenergic receptor kinase activity (ortholog); D1 dopamine receptor binding (ortholog); G protein-coupled receptor kinase activity (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway (ortholog); G protein-coupled receptor signaling pathway (ortholog); inositol phosphate metabolic process (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH bipolar disorder (ortholog); Cardiomegaly (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN axon terminus (ortholog); dendrite terminus (ortholog); dendritic shaft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Adrbk2; adrenergic, beta, receptor kinase 2; beta-adrenergic receptor kinase 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,640,145 - 19,785,803 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,640,145 - 19,785,803 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Grk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,640,145 - 19,785,803 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,640,145 - 19,785,803 (-)NCBIChiLan1.0ChiLan1.0
GRK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382225,564,675 - 25,729,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2225,564,675 - 25,729,294 (+)EnsemblGRCh38hg38GRCh38
GRCh372225,960,642 - 26,125,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,290,861 - 24,455,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 342224,285,499 - 24,444,470NCBI
Celera229,765,035 - 9,929,436 (+)NCBICelera
Cytogenetic Map22q12.1ENTREZGENE
HuRef228,948,071 - 9,073,051 (+)NCBIHuRef
CHM1_12225,919,893 - 26,084,649 (+)NCBICHM1_1
T2T-CHM13v2.02226,025,826 - 26,190,440 (+)NCBIT2T-CHM13v2.0
Grk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,058,344 - 113,163,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,058,348 - 113,163,657 (-)EnsemblGRCm39 Ensembl
GRCm385112,910,478 - 113,015,660 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5112,910,482 - 113,015,791 (-)EnsemblGRCm38mm10GRCm38
MGSCv375113,339,498 - 113,444,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365113,150,781 - 113,255,817 (-)NCBIMGSCv36mm8
Celera5110,031,311 - 110,133,492 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.29NCBI
Grk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,285,228 - 49,395,803 (+)NCBIGRCr8
mRatBN7.21243,624,778 - 43,735,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,624,897 - 43,731,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,792,406 - 44,899,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,404,111 - 45,510,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,464,630 - 44,571,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01249,626,871 - 49,750,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,626,871 - 49,746,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,433,367 - 51,510,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,261,279 - 45,319,394 (+)NCBICelera
Cytogenetic Map12q16NCBI
GRK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22335,460,616 - 35,733,621 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12238,268,625 - 38,432,427 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0226,579,664 - 6,789,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12224,353,530 - 24,516,416 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2224,353,533 - 24,509,560 (+)Ensemblpanpan1.1panPan2
GRK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12619,385,059 - 19,512,528 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2619,385,058 - 19,516,077 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2619,249,805 - 19,382,153 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02619,749,680 - 19,882,193 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2619,749,732 - 19,878,611 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12619,454,629 - 19,586,996 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02619,720,438 - 19,852,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02619,789,809 - 19,922,140 (+)NCBIUU_Cfam_GSD_1.0
Grk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118115,345,722 - 115,443,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936657426,787 - 521,198 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936657425,902 - 522,331 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1443,224,930 - 43,442,965 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11443,305,255 - 43,445,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21446,128,694 - 46,270,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1198,438,543 - 8,601,652 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl198,438,380 - 8,600,359 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045117,529,573 - 117,694,607 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,576,681 - 1,758,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,567,540 - 1,758,251 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000024253   ⟹   ENSCLAP00000024023
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544219,640,145 - 19,785,803 (-)Ensembl
RefSeq Acc Id: XM_005391839   ⟹   XP_005391896
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544219,640,145 - 19,785,745 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005391840   ⟹   XP_005391897
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544219,640,145 - 19,785,713 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517965   ⟹   XP_013373419
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544219,640,145 - 19,785,803 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517966   ⟹   XP_013373420
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544219,640,145 - 19,785,803 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005391896 (Get FASTA)   NCBI Sequence Viewer  
  XP_005391897 (Get FASTA)   NCBI Sequence Viewer  
  XP_013373419 (Get FASTA)   NCBI Sequence Viewer  
  XP_013373420 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024023
  ENSCLAP00000024023.1
RefSeq Acc Id: XP_005391896   ⟸   XM_005391839
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W486 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005391897   ⟸   XM_005391840
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013373419   ⟸   XM_013517965
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013373420   ⟸   XM_013517966
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSCLAP00000024023   ⟸   ENSCLAT00000024253
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase   RGS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016492 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000024253 ENTREZGENE
  ENSCLAT00000024253.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  GPCR_kinase UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Adrbk2 ENTREZGENE
PANTHER BETA-ADRENERGIC RECEPTOR KINASE 2 UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
PRINTS GPCRKINASE UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
SMART RGS UniProtKB/TrEMBL
  S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48097 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2W486 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Grk3  G protein-coupled receptor kinase 3  Adrbk2  adrenergic, beta, receptor kinase 2  Symbol and/or name change 5135510 APPROVED