Sptbn2 (spectrin beta, non-erythrocytic 2) - Rat Genome Database

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Gene: Sptbn2 (spectrin beta, non-erythrocytic 2) Chinchilla lanigera
Analyze
Symbol: Sptbn2
Name: spectrin beta, non-erythrocytic 2
RGD ID: 8994699
Description: ENCODES a protein that exhibits structural constituent of postsynapse (ortholog); INVOLVED IN adult behavior (ortholog); cellular response to ethanol (ortholog); cerebellar Purkinje cell layer morphogenesis (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); autosomal dominant cerebellar ataxia (ortholog); autosomal recessive cerebellar ataxia (ortholog); FOUND IN apical plasma membrane (ortholog); cytosol (ortholog); endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: spectrin beta chain, non-erythrocytic 2; spectrin, beta, non-erythrocytic 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,659,489 - 18,699,338 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,659,489 - 18,699,338 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sptbn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,659,489 - 18,699,338 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,659,489 - 18,699,338 (+)NCBIChiLan1.0ChiLan1.0
SPTBN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381166,682,497 - 66,744,682 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1166,682,496 - 66,744,670 (-)EnsemblGRCh38hg38GRCh38
GRCh371166,449,968 - 66,496,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,209,299 - 66,245,446 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,209,298 - 66,245,446NCBI
Celera1163,779,325 - 63,815,933 (-)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1162,780,849 - 62,816,939 (-)NCBIHuRef
CHM1_11166,336,472 - 66,372,624 (-)NCBICHM1_1
T2T-CHM13v2.01166,678,745 - 66,725,466 (-)NCBIT2T-CHM13v2.0
Sptbn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,761,236 - 4,804,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,761,195 - 4,802,388 (+)EnsemblGRCm39 Ensembl
GRCm38194,711,208 - 4,753,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,711,167 - 4,752,360 (+)EnsemblGRCm38mm10GRCm38
MGSCv37194,711,223 - 4,752,352 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,711,223 - 4,752,352 (+)NCBIMGSCv36mm8
Celera194,582,341 - 4,623,299 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.1NCBI
Sptbn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,432,373 - 211,473,016 (+)NCBIGRCr8
mRatBN7.21202,002,970 - 202,045,343 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,002,970 - 202,044,283 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,356,032 - 210,396,701 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,448,385 - 217,489,036 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,139,403 - 210,180,054 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,964,429 - 220,006,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,964,429 - 220,005,068 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,828,798 - 226,870,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,318,258 - 207,358,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,471,710 - 207,512,349 (+)NCBI
Celera1199,543,481 - 199,584,122 (+)NCBICelera
Cytogenetic Map1q43NCBI
SPTBN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2967,911,052 - 67,955,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11168,953,825 - 68,997,850 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,042,617 - 62,086,634 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,365,588 - 65,409,207 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,365,588 - 65,409,207 (-)Ensemblpanpan1.1panPan2
SPTBN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,631,053 - 50,670,428 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,631,909 - 50,669,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,240,573 - 49,279,278 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01851,662,893 - 51,701,379 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,662,852 - 51,701,369 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,774,519 - 50,803,374 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01850,344,628 - 50,383,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01851,134,515 - 51,173,008 (+)NCBIUU_Cfam_GSD_1.0
Sptbn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,448,050 - 6,486,151 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,890,817 - 2,928,499 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,890,404 - 2,928,502 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTBN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,695,836 - 5,739,415 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,683,414 - 5,739,418 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPTBN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,543,035 - 7,588,125 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl17,556,953 - 7,590,720 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,830,187 - 104,874,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sptbn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,694,241 - 19,734,650 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476719,694,471 - 19,734,653 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000024355   ⟹   ENSCLAP00000024122
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542218,659,489 - 18,699,338 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000024356   ⟹   ENSCLAP00000024123
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542218,660,293 - 18,698,686 (+)Ensembl
RefSeq Acc Id: XM_005384375   ⟹   XP_005384432
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542218,669,011 - 18,699,338 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005384376   ⟹   XP_005384433
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542218,659,489 - 18,699,338 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013513886   ⟹   XP_013369340
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542218,660,293 - 18,699,338 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005384432 (Get FASTA)   NCBI Sequence Viewer  
  XP_005384433 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024122
  ENSCLAP00000024122.1
  ENSCLAP00000024123
  ENSCLAP00000024123.1
RefSeq Acc Id: XP_005384433   ⟸   XM_005384376
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W536 (UniProtKB/TrEMBL),   A0A8C2W728 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005384432   ⟸   XM_005384375
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W728 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369340   ⟸   XM_013513886
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W536 (UniProtKB/TrEMBL),   A0A8C2W728 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000024122   ⟸   ENSCLAT00000024355
Ensembl Acc Id: ENSCLAP00000024123   ⟸   ENSCLAT00000024356
Protein Domains
Calponin-homology (CH)   PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000024355 ENTREZGENE
  ENSCLAT00000024355.1 UniProtKB/TrEMBL
  ENSCLAT00000024356 ENTREZGENE
  ENSCLAT00000024356.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_9 UniProtKB/TrEMBL
  PH_dom-spectrin-type UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_bsu UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
NCBI Gene Sptbn2 ENTREZGENE
PANTHER SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PH_9 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PIRSF Spectrin_beta_subunit UniProtKB/TrEMBL
PRINTS SPECTRINPH UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART SM00033 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A8C2W536 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W728 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Sptbn2  spectrin beta, non-erythrocytic 2    spectrin, beta, non-erythrocytic 2  Symbol and/or name change 5135510 APPROVED