Wnt7b (Wnt family member 7B) - Rat Genome Database

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Gene: Wnt7b (Wnt family member 7B) Chinchilla lanigera
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Symbol: Wnt7b
Name: Wnt family member 7B
RGD ID: 8984404
Description: ENCODES a protein that exhibits chemoattractant activity involved in axon guidance (ortholog); frizzled binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN anatomical structure regression (ortholog); angiogenesis (ortholog); apoptotic process involved in blood vessel morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH breast cancer (ortholog); breast fibroadenoma (ortholog); intellectual disability (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: wingless-type MMTV integration site family, member 7B
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,144,869 - 30,181,791 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,146,185 - 30,185,693 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure regression  (ISO)
angiogenesis  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell population proliferation  (ISO)
cell proliferation in forebrain  (ISO)
cellular response to retinoic acid  (ISO)
central nervous system vasculogenesis  (ISO)
chemoattraction of dopaminergic neuron axon  (ISO)
chorio-allantoic fusion  (ISO)
developmental growth involved in morphogenesis  (ISO)
embryonic organ development  (ISO)
embryonic placenta morphogenesis  (ISO)
establishment or maintenance of polarity of embryonic epithelium  (ISO)
fibroblast proliferation  (ISO)
forebrain regionalization  (ISO)
homeostatic process  (ISO)
in utero embryonic development  (ISO)
inner medullary collecting duct development  (ISO)
intracellular oxygen homeostasis  (ISO)
lobar bronchus development  (ISO)
lung development  (ISO)
lung epithelium development  (ISO)
lung morphogenesis  (ISO)
lung-associated mesenchyme development  (ISO)
mammary gland epithelium development  (ISO)
metanephric collecting duct development  (ISO)
metanephric epithelium development  (ISO)
metanephric loop of Henle development  (ISO)
metanephros morphogenesis  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
neuron differentiation  (ISO)
neuron projection development  (ISO)
neuron projection morphogenesis  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (ISO)
outer medullary collecting duct development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of osteoblast differentiation  (ISO)
regulation of cell projection size  (ISO)
renal inner medulla development  (ISO)
renal outer medulla development  (ISO)
response to glucocorticoid  (ISO)
smooth muscle cell differentiation  (ISO)
stem cell development  (ISO)
stem cell proliferation  (ISO)
synapse organization  (ISO)
trachea cartilage morphogenesis  (ISO)
vasculature development  (ISO)
Wnt signaling pathway  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wnt7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,144,869 - 30,181,791 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,146,185 - 30,185,693 (-)NCBIChiLan1.0ChiLan1.0
WNT7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382245,920,366 - 45,977,162 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2245,920,366 - 45,977,162 (-)EnsemblGRCh38hg38GRCh38
GRCh372246,316,246 - 46,373,042 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,696,316 - 44,751,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 342244,638,195 - 44,666,564NCBI
Cytogenetic Map22q13.31NCBI
HuRef2229,261,652 - 29,291,436 (-)NCBIHuRef
CHM1_12246,275,362 - 46,332,075 (-)NCBICHM1_1
T2T-CHM13v2.02246,405,017 - 46,461,763 (-)NCBIT2T-CHM13v2.0
Wnt7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,419,638 - 85,466,022 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1585,419,638 - 85,466,674 (-)EnsemblGRCm39 Ensembl
GRCm381585,535,437 - 85,581,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,535,437 - 85,582,473 (-)EnsemblGRCm38mm10GRCm38
MGSCv371585,365,867 - 85,412,251 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361585,363,207 - 85,409,348 (-)NCBIMGSCv36mm8
Celera1587,665,622 - 87,712,020 (-)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.39NCBI
Wnt7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,514,684 - 118,559,316 (-)NCBIGRCr8
mRatBN7.27116,634,817 - 116,679,459 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,634,814 - 116,679,581 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,387,429 - 118,429,756 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,613,164 - 120,655,493 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,582,608 - 120,624,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,423,418 - 126,465,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,420,656 - 126,465,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,136,632 - 126,178,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,533,713 - 123,554,333 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17123,567,943 - 123,588,563 (-)NCBI
Celera7112,932,206 - 112,952,808 (-)NCBICelera
Cytogenetic Map7q34NCBI
WNT7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22355,751,220 - 55,807,107 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12258,449,387 - 58,504,009 (-)NCBINHGRI_mPanPan1
PanPan1.12244,988,647 - 45,039,601 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2244,988,647 - 45,044,841 (-)Ensemblpanpan1.1panPan2
WNT7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11020,160,916 - 20,208,786 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1020,160,206 - 20,243,160 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1020,083,094 - 20,132,215 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01020,894,626 - 20,943,739 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,894,149 - 20,976,956 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,614,947 - 20,664,056 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,927,809 - 20,976,907 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01021,108,730 - 21,157,847 (+)NCBIUU_Cfam_GSD_1.0
Wnt7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049453,869,498 - 3,909,805 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,869,523 - 3,909,808 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,869,976 - 3,907,932 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,521,288 - 3,572,314 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.153,521,412 - 3,572,322 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25654,961 - 707,041 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11928,387,324 - 28,444,019 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1928,385,422 - 28,441,350 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604596,912,041 - 96,943,508 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247523,818,025 - 3,857,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247523,818,073 - 3,856,602 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000025119   ⟹   ENSCLAP00000024878
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541330,144,869 - 30,181,791 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000025120   ⟹   ENSCLAP00000024879
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541330,144,869 - 30,167,415 (-)Ensembl
RefSeq Acc Id: XM_013511611   ⟹   XP_013367065
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541330,146,185 - 30,185,693 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013511613   ⟹   XP_013367067
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541330,146,185 - 30,185,610 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013367065 (Get FASTA)   NCBI Sequence Viewer  
  XP_013367067 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024878.1
  ENSCLAP00000024879
  ENSCLAP00000024879.1
RefSeq Acc Id: XP_013367065   ⟸   XM_013511611
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W8R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013367067   ⟸   XM_013511613
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCLAP00000024878   ⟸   ENSCLAT00000025119
Ensembl Acc Id: ENSCLAP00000024879   ⟸   ENSCLAT00000025120


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017076 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025119.1 UniProtKB/TrEMBL
  ENSCLAT00000025120 ENTREZGENE
  ENSCLAT00000025120.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt7 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene Wnt7b ENTREZGENE
PANTHER PROTEIN WNT-7B UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT7PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A8C2W6R9_CHILA UniProtKB/TrEMBL
  A0A8C2W8R4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Wnt7b  Wnt family member 7B    wingless-type MMTV integration site family, member 7B  Symbol and/or name change 5135510 APPROVED