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Gene: Aldob (aldolase, fructose-bisphosphate B) Chinchilla lanigera

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Symbol:

Aldob

Name:

aldolase, fructose-bisphosphate B

RGD ID:

8970770

Description:

ENCODES a protein that exhibits ATPase binding (ortholog); cytoskeletal protein binding (ortholog); fructose binding (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); fructose 1,6-bisphosphate metabolic process (ortholog); fructose catabolic process (ortholog); PARTICIPATES IN forkhead class A signaling pathway; fructose and mannose metabolic pathway; fructosuria pathway; ASSOCIATED WITH autoimmune hepatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); diabetes mellitus (ortholog); FOUND IN centriolar satellite (ortholog); cytosol (ortholog); microtubule organizing center (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	24,377,427 - 24,389,909 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	24,377,427 - 24,389,909 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune hepatitis (ISO)

Chemical and Drug Induced Liver Injury (ISO)

diabetes mellitus (ISO)

Experimental Diabetes Mellitus (ISO)

fructose-1,6-bisphosphatase deficiency (ISO)

genetic disease (ISO)

hereditary fructose intolerance syndrome (ISO)

Hypoxia (ISO)

intellectual disability (ISO)

liver benign neoplasm (ISO)

Long-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency (ISO)

peritonitis (ISO)

Stomach Neoplasms (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (ISO)

fructose 1,6-bisphosphate metabolic process (ISO)

fructose catabolic process (ISO)

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate (ISO)

fructose metabolic process (ISO)

glycolytic process (ISO)

liver development (ISO)

NADH oxidation (ISO)

negative regulation of pentose-phosphate shunt (ISO)

positive regulation of ATP-dependent activity (ISO)

response to amino acid (ISO)

response to cAMP (ISO)

response to carbohydrate (ISO)

response to copper ion (ISO)

response to fructose (ISO)

response to glucocorticoid (ISO)

response to interleukin-6 (ISO)

response to peptide hormone (ISO)

response to starvation (ISO)

response to xenobiotic stimulus (ISO)

response to zinc ion (ISO)

vacuolar proton-transporting V-type ATPase complex assembly (ISO)

Cellular Component

centriolar satellite (ISO)

cytosol (ISO)

microtubule organizing center (ISO)

perinuclear region of cytoplasm (ISO)

rough endoplasmic reticulum membrane (ISO)

smooth endoplasmic reticulum membrane (ISO)

Molecular Function

ATPase binding (ISO)

cytoskeletal protein binding (ISO)

fructose binding (ISO)

fructose-1-phosphate aldolase activity (ISO)

fructose-bisphosphate aldolase activity (ISO)

identical protein binding (ISO)

molecular adaptor activity (ISO)

phosphatidylcholine binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

forkhead class A signaling pathway (ISO)

fructose and mannose metabolic pathway (ISO)

fructosuria pathway (ISO)

gluconeogenesis pathway (ISO)

glycolysis pathway (ISO)

hereditary fructose intolerance syndrome pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Aldob
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	24,377,427 - 24,389,909 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	24,377,427 - 24,389,909 (+)	NCBI	ChiLan1.0	ChiLan1.0

ALDOB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	101,420,560 - 101,435,774 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	101,420,560 - 101,449,664 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	104,182,842 - 104,198,056 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	103,223,479 - 103,237,926 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	101,263,213 - 101,277,660	NCBI
Celera	9	74,696,447 - 74,711,667 (-)	NCBI		Celera
Cytogenetic Map	9	q31.1	NCBI
HuRef	9	73,782,293 - 73,797,509 (-)	NCBI		HuRef
CHM1_1	9	104,329,256 - 104,344,476 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	113,592,536 - 113,607,747 (-)	NCBI		T2T-CHM13v2.0

Aldob
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	49,535,993 - 49,549,546 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	49,535,995 - 49,549,546 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	49,535,993 - 49,549,546 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	49,535,995 - 49,549,546 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	49,548,867 - 49,562,355 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	49,557,095 - 49,570,583 (-)	NCBI		MGSCv36	mm8
Celera	4	49,564,249 - 49,577,800 (-)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	26.57	NCBI

Aldob
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	68,684,541 - 68,697,582 (-)	NCBI		GRCr8
mRatBN7.2	5	63,889,045 - 63,902,086 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	63,889,046 - 63,902,116 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	65,820,242 - 65,833,274 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	67,639,574 - 67,652,612 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	67,608,954 - 67,621,988 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	64,805,772 - 64,818,813 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	64,805,773 - 64,818,824 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	69,297,185 - 69,312,980 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	66,283,165 - 66,296,171 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	66,288,278 - 66,301,295 (-)	NCBI
Celera	5	63,706,063 - 63,718,940 (+)	NCBI		Celera
RH 3.4 Map	5	428.2	RGD
Cytogenetic Map	5	q22	NCBI

ALDOB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	37,931,727 - 37,950,064 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	37,934,099 - 37,952,436 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	72,630,064 - 72,650,918 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	100,624,151 - 100,645,030 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	100,624,151 - 100,638,597 (-)	Ensembl	panpan1.1		panPan2

ALDOB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	58,150,621 - 58,166,266 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	58,150,967 - 58,176,319 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	56,596,344 - 56,610,538 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	59,287,382 - 59,301,579 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	59,284,442 - 59,301,485 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	57,797,128 - 57,811,322 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	57,810,165 - 57,824,388 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	58,507,786 - 58,521,987 (-)	NCBI		UU_Cfam_GSD_1.0

Aldob
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	173,036,560 - 173,048,699 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	9,584,140 - 9,596,276 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	9,584,302 - 9,592,961 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALDOB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	243,110,585 - 243,141,418 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	243,127,870 - 243,141,504 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	271,728,934 - 271,735,543 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALDOB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	37,993,367 - 38,021,693 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	38,007,265 - 38,021,258 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666035	4,531,807 - 4,546,674 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aldob
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	9,868,260 - 9,880,205 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	9,868,223 - 9,880,205 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005382799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01020345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01007633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000019584 ⟹ ENSCLAP00000019393

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955419	24,377,427 - 24,389,909 (+)	Ensembl

RefSeq Acc Id:

XM_005382799 ⟹ XP_005382856

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955419	24,377,427 - 24,389,909 (+)	NCBI

Sequence:

show sequence

AAAAACTTTAACACGACATCTATAAAACTCTGTGTTCCCAAAGATCCGTCCTGTTGGGCAGCTG
CTGCCTCTCTCAAAGTTTCAAAGTCTAAGAGGACTCTTCTCTCGAAGACCTGTCACCATGGCTC
ATCGATTTCCAGCCCTCACCCCAGAACAGAAGAAGGAGCTCTCGGAAATTGCCCAGCGCATTGT
TGCCAATGGAAAGGGCATCCTGGCTGCAGATGAGTCTGTAGGCACCATGGGAAATCGCCTGCAG
AGGATCAAGGTAGAAAATACTGAAGAGAACCGCCGGCAATTCCGCGAAATCCTTTTCACTGTGG
ACAGTTCCGTCAACAAGAGCATTGGGGGAGTGATCCTTTTCCATGAGACTCTCTACCAGAAGGA
CAGCCAGGGAAATCTGTTCAGAAACATCCTCAAGGAGAAGGGGATTGTGGTGGGCATCAAGTTA
GACCAAGGAAGTGCGCCCCTTGCCGGAACAAACAAAGAAACCACCATTCAAGGGCTTGATGGCC
TCTCCCAGCGCTGTGCTCAGTACAAGAAAGATGGGTGTGACTTTGGAAAGTGGCGTGCTGTGCT
GAGGATTGCCGATCAGTGTCCCTCCAGCCTTGCTATCCAGGAAAACGCCAATGCCCTGGCTCGC
TATGCCAGTATTTGTCAACAGAATGGGCTGGTACCTATTGTGGAACCAGAGGTGATTCCTGATG
GAGACCATGACCTGGAACACTGCCAGTATGTTACTGAGAAGGTTCTGGCTGCTGTCTACAAGGC
CCTGAATGACCATCATGTTTACCTAGAGGGCACCCTGCTAAAACCCAACATGGTGACTGCAGGA
CATGCCTGCACCAAGAAGTATACACCAGAGCAAGTGGCTATGGCTACTGTCACAGCTCTTCATC
GTACTGTTCCCGCAGCTGTTCCTGGCATCTGCTTTTTGTCTGGTGGCATGAGTGAAGAGGATGC
TACTCTCAACCTCAATGCAATCAACCTTTGCCCTCTACCAAAACCTTGGAAACTAAGTTTCTCG
TATGGGCGGGCCTTGCAGGCCAGCGCATTGGCTGCGTGGGCTGGCAAGGCTGCAAACAAGAAGG
CAACACAGGAGGCTTTCATGAAAAGGGCTGTGGCTAATTCTGAGGCAGCCAAAGGAAAGTATGT
TCACACTGGCTCGTCCAGTGCTGCTTCCACCCAGTCACTCTTCACGGCCTCCTATACCTACTAG
GCCCTGATGGCACCAGCTTGGCTCCAGTGTCCTACACGTTGTGGCAGGAAGACTGTAAAGAAAC
AGCCTTACAATCCATCCTGCAAATGAGACAAAATTAGATGGGAACTACTGGAAATACAATCCAT
GCTAAATCTTAAACGTGAGGGAAAAAACAAATTAAACCTAAATATGAATATCAAGGATGTAATT
ATAATTTCACATAATATTTCCTTCCACTTCTAATCCCAATGCTTCAGATTATTCACGCAAGAAA
AGAAAACCAGCTCTCTGGTCAAATAAGAACTGTGGAATGCAGAGAAGTGCATGATATAGAAACA
ATCTCAGCAGTGGTAGGTTATGAAGGAAAGAGTTGAGAGTTGTACCTGCAAAATAAATGACCCA
TAAAACTTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005382856	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000019393
	ENSCLAP00000019393.1

RefSeq Acc Id:

XP_005382856 ⟸ XM_005382799

- UniProtKB:

A0A8C2VWF1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAHRFPALTPEQKKELSEIAQRIVANGKGILAADESVGTMGNRLQRIKVENTEENRRQFREILF
TVDSSVNKSIGGVILFHETLYQKDSQGNLFRNILKEKGIVVGIKLDQGSAPLAGTNKETTIQGL
DGLSQRCAQYKKDGCDFGKWRAVLRIADQCPSSLAIQENANALARYASICQQNGLVPIVEPEVI
PDGDHDLEHCQYVTEKVLAAVYKALNDHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTA
LHRTVPAAVPGICFLSGGMSEEDATLNLNAINLCPLPKPWKLSFSYGRALQASALAAWAGKAAN
KKATQEAFMKRAVANSEAAKGKYVHTGSSSAASTQSLFTASYTY

hide sequence

Ensembl Acc Id:

ENSCLAP00000019393 ⟸ ENSCLAT00000019584

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013299	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000019584	ENTREZGENE
	ENSCLAT00000019584.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/TrEMBL
InterPro	Aldolase_I_AS	UniProtKB/TrEMBL
	Aldolase_TIM	UniProtKB/TrEMBL
	FBA_I	UniProtKB/TrEMBL
NCBI Gene	Aldob	ENTREZGENE
PANTHER	PTHR11627	UniProtKB/TrEMBL
Pfam	Glycolytic	UniProtKB/TrEMBL
PROSITE	ALDOLASE_CLASS_I	UniProtKB/TrEMBL
Superfamily-SCOP	Aldolase	UniProtKB/TrEMBL
UniProt	A0A8C2VWF1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Aldob	aldolase, fructose-bisphosphate B		aldolase B, fructose-bisphosphate	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)