Clcn2 (chloride voltage-gated channel 2) - Rat Genome Database

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Gene: Clcn2 (chloride voltage-gated channel 2) Chinchilla lanigera
Analyze
Symbol: Clcn2
Name: chloride voltage-gated channel 2
RGD ID: 8945258
Description: ENCODES a protein that exhibits chloride channel regulator activity (ortholog); voltage-gated chloride channel activity (ortholog); voltage-gated monoatomic anion channel activity (ortholog); INVOLVED IN acinar cell differentiation (ortholog); cell differentiation involved in salivary gland development (ortholog); cellular hypotonic response (ortholog); ASSOCIATED WITH 3-methylcrotonyl-CoA carboxylase 1 deficiency (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN astrocyte end-foot (ortholog); axon initial segment (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: chloride channel protein 2; chloride channel, voltage-sensitive 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,138,605 - 23,152,311 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Clcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,138,605 - 23,152,311 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBIChiLan1.0ChiLan1.0
CLCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,346,185 - 184,361,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,346,185 - 184,361,650 (-)EnsemblGRCh38hg38GRCh38
GRCh373184,063,973 - 184,079,393 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,547,034 - 185,562,085 (-)NCBINCBI36Build 36hg18NCBI36
Build 343185,547,095 - 185,561,969NCBI
Celera3182,504,875 - 182,520,290 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,470,404 - 181,485,871 (-)NCBIHuRef
CHM1_13184,028,432 - 184,043,898 (-)NCBICHM1_1
T2T-CHM13v2.03187,155,451 - 187,170,873 (-)NCBIT2T-CHM13v2.0
Clcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,521,185 - 20,536,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,521,714 - 20,536,496 (-)EnsemblGRCm39 Ensembl
GRCm381620,702,435 - 20,717,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,702,964 - 20,717,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,703,039 - 20,716,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,616,509 - 20,629,657 (-)NCBIMGSCv36mm8
Celera1621,268,322 - 21,281,991 (-)NCBICelera
Cytogenetic Map16A3- B1NCBI
cM Map1612.5NCBI
Clcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,702,382 - 93,716,059 (+)NCBIGRCr8
mRatBN7.21180,197,741 - 80,211,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,198,153 - 80,211,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1188,920,899 - 88,934,364 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,574,316 - 81,587,781 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,635,378 - 80,648,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,862,664 - 82,876,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,883,879 - 83,897,394 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01186,935,748 - 86,969,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,427,792 - 82,441,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,485,379 - 82,498,880 (+)NCBI
Celera1179,037,893 - 79,051,394 (+)NCBICelera
Cytogenetic Map11q23NCBI
CLCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,219,532 - 182,235,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,223,590 - 182,239,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,383,608 - 181,399,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,865,627 - 189,881,049 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,862,489 - 189,881,049 (-)Ensemblpanpan1.1panPan2
CLCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,224,136 - 17,238,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,223,215 - 17,239,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,309,705 - 21,324,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03417,131,619 - 17,146,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,131,648 - 17,146,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,168,519 - 17,183,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,164,603 - 17,179,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,393,559 - 17,408,134 (-)NCBIUU_Cfam_GSD_1.0
Clcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,433,596 - 119,447,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,525,601 - 5,539,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,525,461 - 5,539,351 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,234,736 - 122,249,867 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,234,731 - 122,249,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,674,508 - 131,689,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,057,687 - 5,073,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,057,900 - 5,073,184 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606313,835,604 - 13,851,241 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,228,189 - 72,244,332 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,228,912 - 72,242,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000022565   ⟹   ENSCLAP00000022360
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542023,138,605 - 23,152,311 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000022566   ⟹   ENSCLAP00000022361
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542023,138,605 - 23,152,311 (+)Ensembl
RefSeq Acc Id: XM_005383315   ⟹   XP_005383372
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005383317   ⟹   XP_005383374
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005383319   ⟹   XP_005383376
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542023,138,558 - 23,152,462 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005383372 (Get FASTA)   NCBI Sequence Viewer  
  XP_005383374 (Get FASTA)   NCBI Sequence Viewer  
  XP_005383376 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000022360
  ENSCLAP00000022360.1
  ENSCLAP00000022361.1
RefSeq Acc Id: XP_005383372   ⟸   XM_005383315
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VYK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383376   ⟸   XM_005383319
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VYK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383374   ⟸   XM_005383317
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VYK2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000022361   ⟸   ENSCLAT00000022566
Ensembl Acc Id: ENSCLAP00000022360   ⟸   ENSCLAT00000022565


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015337 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000022565 ENTREZGENE
  ENSCLAT00000022565.1 UniProtKB/TrEMBL
  ENSCLAT00000022566.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.580.10 UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/TrEMBL
InterPro CBS_dom_sf UniProtKB/TrEMBL
  Cl-channel-2 UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/TrEMBL
  Cl_channel_volt-gated UniProtKB/TrEMBL
NCBI Gene Clcn2 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
  CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
Pfam Voltage_CLC UniProtKB/TrEMBL
PRINTS CLCHANNEL UniProtKB/TrEMBL
  CLCHANNEL2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/TrEMBL
  SSF81340 UniProtKB/TrEMBL
UniProt A0A8C2VYK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YTL3_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Clcn2  chloride voltage-gated channel 2    chloride channel, voltage-sensitive 2  Symbol and/or name change 5135510 APPROVED