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Gene: Panx3 (pannexin 3) Chinchilla lanigera

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Symbol:

Panx3

Name:

pannexin 3

RGD ID:

8911267

Description:

ENCODES a protein that exhibits calcium channel activity (ortholog); gap junction hemi-channel activity (ortholog); INVOLVED IN cell-cell signaling (ortholog); osteoblast differentiation (ortholog); ASSOCIATED WITH chromosome 11 partial duplication syndrome (ortholog); Dwarfism (ortholog); holoprosencephaly 11 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); gap junction (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pannexin-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PANX3 (pannexin 3)	NCBI	Ortholog
Mus musculus (house mouse):	Panx3 (pannexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Panx3 (pannexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PANX3 (pannexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PANX3 (pannexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Panx3 (pannexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PANX3 (pannexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PANX3 (pannexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Panx3 (pannexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	25,676,286 - 25,684,841 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	25,676,286 - 25,684,841 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 11 partial duplication syndrome (ISO)

Dwarfism (ISO)

holoprosencephaly 11 (ISO)

Jacobsen Syndrome (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-cell signaling (ISO)

osteoblast differentiation (ISO)

Cellular Component

endoplasmic reticulum membrane (ISO)

gap junction (ISO)

plasma membrane (ISO)

Molecular Function

calcium channel activity (ISO)

gap junction hemi-channel activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Panx3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	25,676,286 - 25,684,841 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	25,676,286 - 25,684,841 (+)	NCBI	ChiLan1.0	ChiLan1.0

PANX3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	124,611,428 - 124,620,356 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	124,611,428 - 124,620,356 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	124,481,324 - 124,490,252 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	123,986,663 - 123,995,462 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	123,986,662 - 123,995,459	NCBI
Celera	11	121,641,631 - 121,650,429 (+)	NCBI		Celera
Cytogenetic Map	11	q24.2	NCBI
HuRef	11	120,423,913 - 120,432,711 (+)	NCBI		HuRef
CHM1_1	11	124,367,559 - 124,376,376 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	124,640,092 - 124,649,020 (+)	NCBI		T2T-CHM13v2.0

Panx3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	37,571,198 - 37,580,518 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	37,571,198 - 37,580,531 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	37,659,902 - 37,669,222 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	37,659,902 - 37,669,235 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	37,467,487 - 37,476,807 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	37,409,573 - 37,418,893 (-)	NCBI		MGSCv36	mm8
Celera	9	34,876,995 - 34,886,243 (-)	NCBI		Celera
Cytogenetic Map	9	A4	NCBI
cM Map	9	20.79	NCBI

Panx3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	45,554,474 - 45,566,378 (-)	NCBI		GRCr8
mRatBN7.2	8	37,366,758 - 37,377,640 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	37,366,862 - 37,377,640 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	41,383,133 - 41,393,828 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	39,666,197 - 39,676,892 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	37,529,079 - 37,539,775 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	40,126,379 - 40,137,390 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	40,126,342 - 40,137,390 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	40,127,203 - 40,138,214 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	38,902,317 - 38,913,090 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	38,593,394 - 38,921,856 (-)	NCBI
Celera	8	37,077,755 - 37,088,527 (+)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

PANX3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	125,307,247 - 125,319,314 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	126,412,210 - 126,423,820 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	119,438,866 - 119,452,174 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	123,354,919 - 123,363,463 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	123,354,919 - 123,363,463 (+)	Ensembl	panpan1.1		panPan2

PANX3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	9,787,513 - 9,794,292 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	9,787,947 - 9,794,166 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1

Panx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	106,835,538 - 106,842,852 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936743	1,083,227 - 1,090,777 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936743	1,083,217 - 1,092,023 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PANX3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	51,853,949 - 51,861,331 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	51,854,148 - 51,860,330 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	57,372,024 - 57,378,298 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PANX3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	115,757,147 - 115,767,034 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	115,757,901 - 115,766,295 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	10,350,082 - 10,392,302 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Panx3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624927	612,750 - 620,564 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624927	612,686 - 621,282 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005378429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01013170	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000022328 ⟹ ENSCLAP00000022123

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955412	25,676,286 - 25,684,841 (+)	Ensembl

RefSeq Acc Id:

XM_005378429 ⟹ XP_005378486

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955412	25,676,286 - 25,684,841 (+)	NCBI

Sequence:

show sequence

CCGTAAGGCTTTGGCTGCAGCACTGTCTGCCTGAAGCTCTCATCTCTTCACCCCACCATCCCGG
GACACCTCCTGCCACCTCTGCAGCCCCAAGCTCGGCAGCATCATGTCGCTCGCACACACTGCCG
CAGAGTACATGCTCTCTGATGCTCTGCTGCCCGACCGCAGGGGCTCCCGCCTCAAAGGCCTGCG
CCTGGAACTGCCCCTGGACAGGATGGTCAAGTTCGTGGCTGTAGGCTTTCCCTTGTTGCTGATG
TCCCTGGCATTCGCCCAGGAGTTCTCCTCTGGGTCTCCGATGAGCTGCTTCGCTCCCAGTAACT
TCAGCGTGCAGCAGGCTGCTTATGTGGACAGTTCCTGTTGGGACTCACTGGTTCACCACGAACA
GGACGAGGCTGGCCAATACAAGACAAAATCTCTCTGGCCCCACAAGGCCCTCCCCTACTCCCTG
ATGGGCCTGGCTGTGGCCATGTACCTGCCGGTGCTGCTGTGGCAGTGTGCAGCTGTGCCAGCCC
TCAGCTCGGACCTGCTATTCATCATCAGTGAGCTGGACAAATCCTACAACCGCTCCATCCGTCT
GGTGCAGCACATGCTGAAGATCCGGCAGAAGAGCTCTGACCCACATGTCTTCTGGGATGAGCTA
GAGAAGGCCCGGAAAGAACGATACTTTGAATTTCCCTTGCTAGAGCGGTACCTGGCATGTAAGC
AGCGCTCACATTCACTAGTGGCCGCCTACCTCCTAAAGAACTCCCTCTTGCTCCTCTTCACGTC
AGCCACTTACCTGTACCTTGGTCACTTCCATCTGAGTATCTTCTTCCAAGAAGAATTCAGTTGC
TCCATCAAGACAGGGATGCTGCATGATGAAACCCATGTCCCTGATCTGTTCACATGCAGGCTGA
CCTCCCTGTCTGTTTTCCAGATTGTTAGCCTCTCCAGTGTGGCAGTATACACCCTATTGGTTCC
AGTGATAATATACAACCTCACACGACTATGTCGGTGGGACAAACGCCTCCTATCCATCTATGAG
ATGCTCCCAGCTTTTGATCTTCTCAGCAGAAAGATGCTCGGATGCCCCATCAATGACCTCAATG
TGATTCTTCTTTTCCTCCGAGCCAACATCTCTGAGCTCATCTCTTTTAGCTGGCTGAGTGTCTT
ATGTGTGCTGAAGGACACAACCACTCAGAAGCACAACATTGACACAGTGGTTGACTTCATGACT
TTATTGGCTGGCTTAGAACCCTCAAAACCTAAACATCTCACCCAACGAGTATGTGATGAACACC
CATAGTTAAGAAAGAAACTGTGGAGTAAGACATTTTGTGCAAAGTAAGTCTCTCACCATCTTCA
CAAGCCACACATAGTAATACACAAAAATACTCACTTCAGAATTGCCAAACTTGGATTTAGATGA
GCTATATATTCCACACTTGTAAGAAGATATAACTAAGACATGGAAATAAATATGAAACCTGGAA
TACAAGTCAAGGAACTAAACTAAACTAAATGTCTGGAACATTTTACAAGGGTATTAAAAATAAA
CAGAAATAAAGTCTAGGAATTCTGTAAGAAAAGAGGGTTATAAAGGCTGTTTATACAGGCAGGT
TTTCACTACATTCAACTCATGGCCCTTCTATGGTATATACTTAGCTTACCTCAAAGAGCAAGTG
AGCAACATGGTGAGAAATTAATAGATGTTAAATCCCTGGAAATCCTTTGGTATGAACTGAAATC
CTAAAAATTTGCCCAATTTTGCTTTGTGGAAGTCATCAGTCTTGCCAGGCCCTGTGTGACCTGC
CAAATGAGTGAGGAGATAATGATGGCTTCCACCTGTAGTCTGCTCTTGGGGTTTGAAAACAGAG
GCAAGTGCCATGCAGTGCCATAAGTGAAGTCTTGAGGTATCCAGGTATACTTTTCATCATCTAA
ATCCAGGTATACTTTTCATCATCTAAACCAAAGACTCATTTCACTAAAAGCTGGGATTATGGGC
CATGGGCTCCTTCATAACTTTTAATGAGCCCAAGGATGTTTTAATACCTCAGGGGACTCTATAC
CTTCCTTACAGCCAGTCACTGGATAGCAATCACTTAGAACTAAAACAAATACACAAAAAAGGTG
CTCACTAAGTGCTAGTGAGCCCCTTCCTTCAGTCTTTCCCCTCATTTATCATTTCATCCTTACA
GCAAACTCCCAACCTTATACCTGGAGCACTGATCTGATTCCAAAAATATGGTCAGCCCACAATA
CCACGCTGTCTTACATTTTATATTTCTTTTTAAAGCTACCCATTATGCACTTCTCGGGAGAATT
GTTTGCATAGGCCATTTAGACCCCTCTACGTATAAATTAGTAGAAAAGTTATGTTGCTTCTGCC
AAATTCAGATGTTTGCCTAAAAACAAGCAATAAGCTCATATATCAATACTCATAAACGACTTTT
ATTGCCAATAAAAGTCCAACTCGTCAGTTGGTACAGAAGCCCTTTCAAGACCTAAGCCCTGCTC
AAAACTTGTCCCTCCTCTTGCTTCCCTCCACACACAGCTTTCCCTTTAATCAATGACCTGCAGT
TCCCATGCTTCTCATGACGCTAAACATTGGAAGAAGCTGTCTGCCTGCCTAGCATGCTCTCCTC
CGGGTCAATTGTTATCTCTCCTTGCAAGCATACTCAGGCATATTTCCTTCAAGCAGCTTTCCTA
TTTCCTACCCCGTTCCCTAACTGGGTACTCCCATAGCAAGTAAAACCTACCTCTGAAAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005378486	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022123
	ENSCLAP00000022123.1

RefSeq Acc Id:

XP_005378486 ⟸ XM_005378429

- UniProtKB:

A0A8C2VXJ6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSLAHTAAEYMLSDALLPDRRGSRLKGLRLELPLDRMVKFVAVGFPLLLMSLAFAQEFSSGSPM
SCFAPSNFSVQQAAYVDSSCWDSLVHHEQDEAGQYKTKSLWPHKALPYSLMGLAVAMYLPVLLW
QCAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPHVFWDELEKARKERYFEFPLL
ERYLACKQRSHSLVAAYLLKNSLLLLFTSATYLYLGHFHLSIFFQEEFSCSIKTGMLHDETHVP
DLFTCRLTSLSVFQIVSLSSVAVYTLLVPVIIYNLTRLCRWDKRLLSIYEMLPAFDLLSRKMLG
CPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLT
QRVCDEHP

hide sequence

Ensembl Acc Id:

ENSCLAP00000022123 ⟸ ENSCLAT00000022328

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015168	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022328	ENTREZGENE
	ENSCLAT00000022328.1	UniProtKB/TrEMBL
InterPro	Innexin	UniProtKB/TrEMBL
	Pannexin	UniProtKB/TrEMBL
NCBI Gene	Panx3	ENTREZGENE
PANTHER	PANNEXIN-3	UniProtKB/TrEMBL
	PTHR15759	UniProtKB/TrEMBL
Pfam	Innexin	UniProtKB/TrEMBL
PROSITE	PANNEXIN	UniProtKB/TrEMBL
UniProt	A0A8C2VXJ6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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