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Gene: Top1 (DNA topoisomerase I) Chinchilla lanigera

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Symbol:

Top1

Name:

DNA topoisomerase I

RGD ID:

8905570

Description:

ENCODES a protein that exhibits ATP binding (ortholog); chromatin binding (ortholog); chromatin DNA binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to luteinizing hormone stimulus (ortholog); chromatin remodeling (ortholog); PARTICIPATES IN irinotecan pharmacodynamics pathway; irinotecan pharmacokinetics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); disease of cellular proliferation (ortholog); Disease Progression (ortholog); FOUND IN cytoplasm (ortholog); dense fibrillar component (ortholog); fibrillar center (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA topoisomerase 1; topoisomerase (DNA) I

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TOP1 (DNA topoisomerase I)	NCBI	Ortholog
Mus musculus (house mouse):	Top1 (topoisomerase (DNA) I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	15,834,017 - 15,922,785 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	15,834,017 - 15,922,785 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

disease of cellular proliferation (ISO)

Disease Progression (ISO)

focal epilepsy (ISO)

Liver Neoplasms (ISO)

Ovarian Neoplasms (ISO)

Recurrence (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ regeneration (ISO)

cellular response to luteinizing hormone stimulus (ISO)

chromatin remodeling (ISO)

circadian regulation of gene expression (ISO)

circadian rhythm (ISO)

DNA replication (ISO)

DNA topological change (ISO)

embryonic cleavage (ISO)

peptidyl-serine phosphorylation (ISO)

response to cAMP (ISO)

response to gamma radiation (ISO)

response to temperature stimulus (ISO)

response to xenobiotic stimulus (ISO)

rRNA transcription (ISO)

Cellular Component

cytoplasm (ISO)

dense fibrillar component (ISO)

fibrillar center (ISO)

male germ cell nucleus (ISO)

nuclear chromosome (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (ISO)

P-body (ISO)

perikaryon (ISO)

protein-DNA complex (ISO)

Molecular Function

ATP binding (ISO)

chromatin binding (ISO)

chromatin DNA binding (ISO)

DNA binding (ISO)

DNA binding, bending (ISO)

DNA topoisomerase type I (single strand cut, ATP-independent) activity (ISO)

double-stranded DNA binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein serine/threonine kinase activity (ISO)

protein-containing complex binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

single-stranded DNA binding (ISO)

supercoiled DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Top1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	15,834,017 - 15,922,785 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	15,834,017 - 15,922,785 (-)	NCBI	ChiLan1.0	ChiLan1.0

TOP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	41,028,822 - 41,124,487 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	41,028,822 - 41,124,487 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	39,657,462 - 39,753,127 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	39,090,876 - 39,186,541 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	39,090,875 - 39,186,541	NCBI
Celera	20	36,368,028 - 36,463,696 (+)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI
HuRef	20	36,395,468 - 36,491,177 (+)	NCBI		HuRef
CHM1_1	20	39,561,887 - 39,657,539 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	42,760,511 - 42,856,164 (+)	NCBI		T2T-CHM13v2.0

Top1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	160,487,901 - 160,564,684 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	160,487,808 - 160,564,684 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	160,645,897 - 160,722,764 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	160,645,888 - 160,722,764 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	160,471,633 - 160,548,500 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	160,337,671 - 160,414,152 (+)	NCBI		MGSCv36	mm8
Celera	2	166,577,915 - 166,654,823 (+)	NCBI		Celera
Cytogenetic Map	2	H2	NCBI
cM Map	2	80.96	NCBI

Top1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	169,713,195 - 169,796,330 (+)	NCBI		GRCr8
mRatBN7.2	3	149,293,469 - 149,376,618 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	149,293,403 - 149,376,623 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	153,107,309 - 153,188,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	161,606,688 - 161,687,898 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	159,345,818 - 159,427,549 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	156,635,688 - 156,717,686 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	156,642,464 - 156,717,686 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	162,865,335 - 162,947,076 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	151,428,931 - 151,512,884 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	151,334,966 - 151,418,920 (+)	NCBI
Celera	3	147,968,261 - 148,049,789 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

TOP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	46,769,898 - 46,866,351 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	46,762,969 - 46,859,450 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	37,368,606 - 37,464,649 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	38,468,197 - 38,563,842 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	38,468,452 - 38,562,652 (+)	Ensembl	panpan1.1		panPan2

TOP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	29,075,267 - 29,166,733 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	29,075,492 - 29,165,864 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	28,720,984 - 28,812,380 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	29,781,234 - 29,872,485 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	29,781,498 - 29,872,296 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	29,049,969 - 29,141,401 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	29,153,861 - 29,245,250 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	29,650,217 - 29,741,420 (+)	NCBI		UU_Cfam_GSD_1.0

Top1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	178,026,161 - 178,108,033 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	641,423 - 723,518 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	641,451 - 723,323 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	43,710,290 - 43,799,700 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	43,710,270 - 43,799,700 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	49,135,554 - 49,193,582 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	22,655,085 - 22,751,082 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	22,651,995 - 22,751,102 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	71,467,009 - 71,562,443 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Top1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624919	1,668,440 - 1,756,629 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624919	1,668,712 - 1,756,624 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005392521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01039857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01039858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01039859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01039860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01176800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000012712 ⟹ ENSCLAP00000012564

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955445	15,834,017 - 15,922,785 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000012713 ⟹ ENSCLAP00000012565

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955445	15,835,201 - 15,894,388 (-)	Ensembl

RefSeq Acc Id:

XM_005392521 ⟹ XP_005392578

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955445	15,834,017 - 15,922,785 (-)	NCBI

Sequence:

show sequence

GCCTGCGCCGCCTCGCAGTCCGCCGCGCCCGTCGCGTTCGCCGCGCCGGTCGACATGAGTGGGG
ACCATCTCCACAACGATTCCCAGATCGAAGCGGATTTCCGACTGAATGATTCTCATAAACACAA
AGATAAACACAAAGATCGAGAACACCGGCATAAAGAGCACAAGAAGGACAAGGAAAAGGACCGG
GAAAAGTCCAAGCATAGCAACAGTGAACATAAAGATTTTGAAAAGAAACACAAAGAGAAGGAGA
AAACTAAACACAAAGATGGAAGCTCAGAAAAGCATAAAGACAAACACAAAGACAGAGACAAGGA
AAAACGAAAGGAGGAAAAGGTTAGAGCCTCTGGGGATGCAAAAATAAAGAAGGAGAAGGAAAAT
GGCTTCTCTAGCCCACCACGAATTAAAGATGAACCTGAAGATGATGGTTATTTTGCTCCTCCTC
CTAAAGAGGATCTAAAGCCATTGAAGAGACCTCGAGATGAGGATGATGCTGATTACAAACCTAA
GAAAATTAAAACAGAAGATATCAAGAAGGAGAAGAAACGAAAACCAGAGGAAGAGGAGGATGGT
AAACTGAAAAAACCCAAGAATAAAGATAAAGATAAAAAACTTCCTGAGCCAGATAACAAGAAAA
AGAAGCCGAAGAAAGAAGAGGAACAGAAATGGAAATGGTGGGAAGAAGAACGCTATCCTGAAGG
CATCAAGTGGAAATTCCTAGAACATAAAGGTCCTGTATTTGCTCCACCGTATGAGCCTCTTCCA
GAAAGTGTCAAGTTTTACTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAAGAAATAG
CTACATTCTTTGCAAAAATGCTCGATCATGAATATACTACTAAGGAAATATTTAGGAAAAATTT
CTTTAAAGATTGGAGAAAGGAAATGACAAATGAAGAGAAGAATACTATCACCAACCTAAGCAAA
TGTGATTTTACTCAGATGAGCCAGTATTTCAAAGCCCAGTCGGAAGCCCGAAAACAGATGAGCA
AAGAAGAAAAATTGAAAATCAAAGAGGAAAACGAAAAATTACTAAAAGAATATGGCTTCTGTAT
TATGGATAACCACAGAGAGAGGATTGCTAACTTCAAGATAGAGCCCCCGGGACTATTCCGTGGC
CGGGGCAACCACCCCAAGATGGGCATGCTGAAGCGGAGGATCCTGCCTGAGGACATCATCATAA
ACTGCAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCCAGGACATAAGTGGAAAGAGGTCAGGCA
TGACAACAAAGTAACTTGGCTGGTCTCCTGGACAGAGAATATCCAAGGTTCCATTAAATACATC
ATGTTGAATCCTAGTTCACGAATCAAGGGTGAGAAAGACTGGCAGAAATATGAGACAGCTCGGC
GGCTGAAGAAGTGTGTGGACAAGATCCGAAACCAGTATCGAGAAGACTGGAAGTCCAAAGAGAT
GAAAGTCCGGCAAAGAGCTGTAGCATTGTATTTCATTGACAAGCTTGCTCTGAGAGCAGGAAAT
GAGAAGGAAGAAGGAGAAACAGCAGACACTGTAGGTTGCTGTTCACTTCGTGTGGAGCATATCA
ACTTGCACCCAGAATTGGATGGTCAGGAGTACGTGGTTGAGTTTGACTTCCTTGGGAAGGACTC
CATTAGATACTATAACAAGGTCCCAGTTGAGAAACGAGTTTTTAAGAACTTGCAGTTATTTATG
GAGAACAAGCAGCCTGAGGATGATCTGTTTGATAGACTTAATACCGGTATTCTAAATAAGCACC
TTCAGGATCTCATGGAGGGGTTGACGGCCAAGGTGTTTCGTACATATAATGCCTCCATCACGCT
ACAACAGCAGCTAAAAGAACTCACAGCCCCGGATGAAAATATCCCAGCAAAGATTCTCTCTTAC
AACCGTGCCAATCGAGCTGTCGCGATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTTTTG
AAAAGTCTATGATGAACTTGCAGTCTAAGATTGATGCCAAGAAGGATCAGCTAGCAGATGCTCG
GAGGGACCTGAAAAGTGCTAAAGCTGATGCCAAAGTCATGAAGGACGCAAAGACCAAGAAGGTA
GTAGAGTCCAAGAAGAAGGCTGTGCAGAGACTGGAAGAGCAGCTGATGAAGCTGGAAGTTCAGG
CTACAGACCGTGAGGAGAATAAGCAAGTTGCTTTGGGAACCTCCAAACTTAATTATCTGGACCC
TAGGATCACAGTGGCTTGGTGCAAGAAGTGGGGGGTTCCAATTGAAAAAATTTTCAACAAAACC
CAACGGGAGAAGTTTGCGTGGGCCATCGACATGGCTGATGAGGACTACGAGTTTTAACCAATCT
GAAGGGACAGGGTTCTGTGAAAAGAACAGTATGATTTGGGGAAGATGCATAAACTGTGAGCCTC
ACTTGCCCTCATGCCTGAGGGAGAGAGGCAGCAAGTCTTAACCAACATCTTTGCGAAAAGATAA
ACCTGGAGATATTATAAGGGAGAGCTGAGCCAGTTGTCCTATGGACAACTTATTTAAAAATATT
TCAGATATCAAAATTCTAGCTGTATGATTTGTTTTGAATTTTGTTTTTTATTTTCAAGGGGGCA
AGTGGATGGGGATTTGTCAGCGTTTTGCCAGGCAAATTCACTGTTTCACTGAAGTGTTTGGATT
CTCTTAGCTACTGTATGCGAAGTCCGATTATATTGGTGCGTTTTTACAGTTAGGGTTTTGCAAT
AACTTCTATATTTTAATAGAAACAAATTCCTAAACTCCCTCCCCTCTCCCCCATTTCAGGAATT
TAAAACTAAGTAGAACAAAAACCCAGCGCACCTGTTAGAGTTGTCACTCTATTGTCATGGGAAT
CAGTTTTCATTAGACTTGAAGCAGTCGTGACATTGGCAGTGTTTTGGTTCAGACACCTGTTCAC
AGAAAAGCATGATGGGAAAATATTTCCTGACTTGAGTGTTCCTTTTTAAATGTGAATTTTTATT
TCTTTTTAATTATTTTAAAATATTTAAACCTTTTTCTTGATCTTAAAGATCGTGTAAATTGGGG
TTGGGGAGGGATGAAGGGCGAGTGAGTCTCTAAGGATAATGAAATAATCAATGACTGAAACCAT
TTTCCCATCATTCTTTGTTCAGAGCATTCTCTGTACCCTTAAAAATATCCATCTTTTTCTTTTC
AAACCTGTCTTTCACTTGAAAGATTTTATTGTATGAAAAGTTCCACAGGTCAATAAATTTAGAG
GAAAATGAGTATTTGGCCCAACAGAGAAAAAATAATCAAGATTTTAGGGCTTTTATTTTTTTCT
TTTGTAATTGTGTAAAAAATGGGAAAAAACATAAAAAGCAGAATTTTAATGTGAAAACATTTTT
TGCTATAATCATTAGTTTTAGAGGCATTGTTAGTTTAGTGTGTGTGCAGAGTCCATTTCCCACA
TCTTTCCTCAAGTATCTTCTATTTTTATCATGAATTCCCTTTTAATCAACTGTAGGTTATTTAA
AATAAATTCCTACAACTTAATGGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005392578	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012564
	ENSCLAP00000012564.1
	ENSCLAP00000012565.1

RefSeq Acc Id:

XP_005392578 ⟸ XM_005392521

- UniProtKB:

A0A8C2VA98 (UniProtKB/TrEMBL), A0A8C2YNY2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKEKDREKSKHSNSEHKDFEKKHK
EKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPRIKDEPEDDGYF
APPPKEDLKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKPEEEEDGKLKKPKNKDKDKKLPEPD
NKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKA
EEIATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNTITNLSKCDFTQMSQYFKAQSEARK
QMSKEEKLKIKEENEKLLKEYGFCIMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRILPED
IIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYE
TARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRV
EHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGIL
NKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPP
KTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKL
EVQATDREENKQVALGTSKLNYLDPRITVAWCKKWGVPIEKIFNKTQREKFAWAIDMADEDYEF

hide sequence

Ensembl Acc Id:

ENSCLAP00000012565 ⟸ ENSCLAT00000012713

Ensembl Acc Id:

ENSCLAP00000012564 ⟸ ENSCLAT00000012712

Protein Domains

DNA topoisomerase I eukaryotic-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008693	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000012712	ENTREZGENE
	ENSCLAT00000012712.1	UniProtKB/TrEMBL
	ENSCLAT00000012713.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.41	UniProtKB/TrEMBL
	1.10.132.10	UniProtKB/TrEMBL
	2.170.11.10	UniProtKB/TrEMBL
	Topoisomerase I, Chain A, domain 3	UniProtKB/TrEMBL
InterPro	DNA_brk_join_enz	UniProtKB/TrEMBL
	DNA_topo_DNA_db_N_dom1	UniProtKB/TrEMBL
	DNA_topo_DNA_db_N_dom2	UniProtKB/TrEMBL
	TopoI	UniProtKB/TrEMBL
	TopoI_AS	UniProtKB/TrEMBL
	TopoI_C_dom	UniProtKB/TrEMBL
	TopoI_cat_a-hlx-sub_euk	UniProtKB/TrEMBL
	TopoI_cat_a/b-sub_euk	UniProtKB/TrEMBL
	TopoI_cat_euk	UniProtKB/TrEMBL
	TopoI_DNA-bd_euk	UniProtKB/TrEMBL
	TopoI_DNA-bd_euk_N_sf	UniProtKB/TrEMBL
	TopoI_euk	UniProtKB/TrEMBL
	Topoisomer_I_DNA-bd	UniProtKB/TrEMBL
	Topoisomerase_IB	UniProtKB/TrEMBL
NCBI Gene	Top1	ENTREZGENE
PANTHER	DNA TOPOISOMERASE 1	UniProtKB/TrEMBL
	DNA TOPOISOMERASE I	UniProtKB/TrEMBL
Pfam	Topo_C_assoc	UniProtKB/TrEMBL
	Topoisom_I	UniProtKB/TrEMBL
	Topoisom_I_N	UniProtKB/TrEMBL
PRINTS	EUTPISMRASEI	UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_I_EUK	UniProtKB/TrEMBL
SMART	TOPEUc	UniProtKB/TrEMBL
Superfamily-SCOP	Eukaryotic DNA topoisomerase I, dispensable insert domain	UniProtKB/TrEMBL
	SSF56349	UniProtKB/TrEMBL
	SSF56741	UniProtKB/TrEMBL
UniProt	A0A8C2VA98	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2YNY2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-08	Top1	DNA topoisomerase I		topoisomerase (DNA) I	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB