Hmgb1 (high mobility group box 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hmgb1 (high mobility group box 1) Chinchilla lanigera
Analyze
Symbol: Hmgb1
Name: high mobility group box 1
RGD ID: 8885884
Description: ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); C-X-C chemokine binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); activation of innate immune response (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN cisplatin drug pathway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); cell surface (ortholog); chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: high mobility group protein B1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543115,373,207 - 15,377,339 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543115,373,207 - 15,377,339 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
Acute Lung Injury  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (ISO)
Binge Drinking  (ISO)
Brachyphalangy, Polydactyly, and Tibial Aplasia/Hypoplasia  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemotherapy-Related Cognitive Impairment  (ISO)
Chronic Allograft Dysfunction  (ISO)
colon adenocarcinoma  (ISO)
congestive heart failure  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (ISO)
esophagus squamous cell carcinoma  (ISO)
essential hypertension  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
extrahepatic cholestasis  (ISO)
Fever  (ISO)
genetic disease  (ISO)
Heat Stroke  (ISO)
high grade glioma  (ISO)
hydrocephalus  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Inflammation  (ISO)
Intestinal Reperfusion Injury  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
leukostasis  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neuralgia  (ISO)
Neurodevelopmental Disorders  (ISO)
obstructive jaundice  (ISO)
osteoarthritis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Painful Neuropathy  (ISO)
periodontitis  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
Premature Aging  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
systemic scleroderma  (ISO)
Systemic Vasculitis  (ISO)
transient cerebral ischemia  (ISO)
Ventilator-Induced Lung Injury  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
activation of innate immune response  (ISO)
apoptotic cell clearance  (ISO)
base-excision repair  (ISO)
cell morphogenesis  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-7  (ISO)
cellular response to lipopolysaccharide  (ISO)
chemotaxis  (ISO)
chromatin organization  (ISO)
circadian rhythm  (ISO)
DNA geometric change  (ISO)
double-strand break repair  (ISO)
double-strand break repair via nonhomologous end joining  (ISO)
endothelial cell chemotaxis  (ISO)
endothelial cell proliferation  (ISO)
eye development  (ISO)
glycogen catabolic process  (ISO)
heterochromatin formation  (ISO)
induction of positive chemotaxis  (ISO)
inflammatory response  (ISO)
inflammatory response to antigenic stimulus  (ISO)
lung development  (ISO)
macrophage activation involved in immune response  (ISO)
male-specific defense response to bacterium  (ISO)
memory  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
myeloid cell differentiation  (ISO)
myeloid dendritic cell activation  (ISO)
myeloid progenitor cell differentiation  (ISO)
myoblast proliferation  (ISO)
negative regulation of apoptotic cell clearance  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of CD4-positive, alpha-beta T cell differentiation  (ISO)
negative regulation of DNA replication  (ISO)
negative regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of type II interferon production  (ISO)
nervous system development  (ISO)
neuron apoptotic process  (ISO)
neuron projection development  (ISO)
neutrophil clearance  (ISO)
nucleosome assembly  (ISO)
plasmacytoid dendritic cell activation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of dendritic cell differentiation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of glycogen catabolic process  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-1 production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage inflammatory protein 1 alpha production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mismatch repair  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of myeloid cell apoptotic process  (ISO)
positive regulation of myeloid cell differentiation  (ISO)
positive regulation of myeloid progenitor cell differentiation  (ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of toll-like receptor 2 signaling pathway  (ISO)
positive regulation of toll-like receptor 4 signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
positive regulation of wound healing  (ISO)
protein-containing complex assembly  (ISO)
psychomotor behavior  (ISO)
regulation of nucleotide-excision repair  (ISO)
regulation of restriction endodeoxyribonuclease activity  (ISO)
regulation of T cell mediated immune response to tumor cell  (ISO)
regulation of tolerance induction  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to type II interferon  (ISO)
response to xenobiotic stimulus  (ISO)
T-helper 1 cell activation  (ISO)
T-helper 1 cell differentiation  (ISO)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
transcription by RNA polymerase II  (ISO)
V(D)J recombination  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hmgb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543115,373,207 - 15,377,339 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543115,373,207 - 15,377,339 (+)NCBIChiLan1.0ChiLan1.0
HMGB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,456,704 - 30,617,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1330,456,704 - 30,617,597 (-)EnsemblGRCh38hg38GRCh38
GRCh371331,030,841 - 31,191,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361329,930,877 - 29,938,081 (-)NCBINCBI36Build 36hg18NCBI36
Celera1312,102,423 - 12,109,630 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1311,850,667 - 11,857,904 (-)NCBIHuRef
CHM1_11331,000,434 - 31,007,630 (-)NCBICHM1_1
T2T-CHM13v2.01329,679,118 - 29,839,654 (-)NCBIT2T-CHM13v2.0
Hmgb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395148,983,512 - 148,989,867 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5148,983,512 - 149,121,299 (-)EnsemblGRCm39 Ensembl
GRCm385149,046,702 - 149,053,057 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,046,702 - 149,184,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv375149,858,803 - 149,864,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365149,357,579 - 149,363,386 (-)NCBIMGSCv36mm8
Celera5147,061,615 - 147,067,633 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Hmgb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,009,236 - 11,015,941 (+)NCBIGRCr8
mRatBN7.2125,972,950 - 5,979,658 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,901,586 - 5,978,565 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1634,028,446 - 34,030,648 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,644,838 - 6,651,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,267,954 - 7,274,667 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,295,972 - 6,302,685 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0127,082,529 - 7,090,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,500,017 - 37,502,237 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0129,177,615 - 9,178,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11637,462,230 - 37,464,451 (+)NCBI
Celera127,732,744 - 7,737,689 (+)NCBICelera
Cytogenetic Map12p11NCBI
HMGB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,044,445 - 30,202,275 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,152,234 - 21,308,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01311,737,942 - 11,894,923 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,173,875 - 30,179,527 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,174,899 - 30,179,527 (-)Ensemblpanpan1.1panPan2
HMGB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,431,223 - 9,558,167 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,431,218 - 9,558,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha259,596,948 - 9,603,279 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,542,952 - 9,670,011 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,663,749 - 9,670,011 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,558,389 - 9,564,743 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0259,566,227 - 9,572,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,608,257 - 9,614,621 (+)NCBIUU_Cfam_GSD_1.0
Hmgb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,705,559 - 170,715,427 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,236,728 - 25,246,580 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,236,728 - 25,246,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1117,195,556 - 7,321,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,006,105 - 7,131,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,353,333 - 9,357,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605735,008,842 - 35,015,311 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmgb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,793,259 - 7,863,184 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247767,858,400 - 7,862,716 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000004787   ⟹   ENSCLAP00000004700
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543115,373,207 - 15,377,339 (+)Ensembl
RefSeq Acc Id: XM_005387745   ⟹   XP_005387802
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543115,373,207 - 15,377,339 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005387802 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000004700
  ENSCLAP00000004700.1
RefSeq Acc Id: XP_005387802   ⟸   XM_005387745
- UniProtKB: A0A8C2URC2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000004700   ⟸   ENSCLAT00000004787
Protein Domains
HMG box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003343 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004787 ENTREZGENE
  ENSCLAT00000004787.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  HMG_boxA_CS UniProtKB/TrEMBL
  HMGB UniProtKB/TrEMBL
NCBI Gene Hmgb1 ENTREZGENE
PANTHER HIGH MOBILITY GROUP PROTEIN B1 UniProtKB/TrEMBL
  HIGH MOBILITY GROUP PROTEIN DSP1 UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/TrEMBL
  HMG_box_2 UniProtKB/TrEMBL
PRINTS HIGHMOBLTY12 UniProtKB/TrEMBL
PROSITE HMG_BOX_1 UniProtKB/TrEMBL
  HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A8C2URC2 ENTREZGENE, UniProtKB/TrEMBL