Wnt4 (Wnt family member 4) - Rat Genome Database

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Gene: Wnt4 (Wnt family member 4) Chinchilla lanigera
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Symbol: Wnt4
Name: Wnt family member 4
RGD ID: 8877016
Description: ENCODES a protein that exhibits frizzled binding (ortholog); receptor ligand activity (ortholog); transcription corepressor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); apoptotic signaling pathway (ortholog); branching involved in ureteric bud morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); 46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and Lungs (ortholog); acute kidney failure (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: wingless-type MMTV integration site family, member 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,319,446 - 2,344,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,319,446 - 2,344,740 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
apoptotic signaling pathway  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
canonical Wnt signaling pathway  (ISO)
cell differentiation  (ISO)
cell fate commitment  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
embryonic epithelial tube formation  (ISO)
epithelial to mesenchymal transition  (ISO)
female gonad development  (ISO)
female sex determination  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
gamete generation  (ISO)
hormone metabolic process  (ISO)
immature T cell proliferation in thymus  (ISO)
kidney development  (ISO)
kidney morphogenesis  (ISO)
liver development  (ISO)
male gonad development  (ISO)
mammary gland epithelium development  (ISO)
meiotic nuclear division  (ISO)
mesenchymal to epithelial transition  (ISO)
mesonephric tubule development  (ISO)
mesonephros development  (ISO)
metanephric nephron development  (ISO)
metanephric nephron morphogenesis  (ISO)
metanephric tubule formation  (ISO)
metanephros development  (ISO)
negative regulation of androgen biosynthetic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of male gonad development  (ISO)
negative regulation of steroid biosynthetic process  (ISO)
negative regulation of testicular blood vessel morphogenesis  (ISO)
negative regulation of testosterone biosynthetic process  (ISO)
negative regulation of wound healing  (ISO)
nephron development  (ISO)
non-canonical Wnt signaling pathway  (ISO)
oocyte development  (ISO)
paramesonephric duct development  (ISO)
pericyte cell differentiation  (ISO)
positive regulation of aldosterone biosynthetic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cortisol biosynthetic process  (ISO)
positive regulation of dermatome development  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of meiotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of stress fiber assembly  (ISO)
regulation of cell-cell adhesion  (ISO)
renal vesicle formation  (ISO)
renal vesicle induction  (ISO)
response to benzoic acid  (ISO)
response to estradiol  (ISO)
response to retinoic acid  (ISO)
Sertoli cell differentiation  (ISO)
sex differentiation  (ISO)
smooth muscle cell differentiation  (ISO)
somatotropin secreting cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
tertiary branching involved in mammary gland duct morphogenesis  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
tube morphogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wnt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,319,446 - 2,344,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,319,446 - 2,344,740 (-)NCBIChiLan1.0ChiLan1.0
WNT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,117,313 - 22,143,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,117,313 - 22,143,969 (-)EnsemblGRCh38hg38GRCh38
GRCh37122,443,806 - 22,469,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,316,385 - 22,342,106 (-)NCBINCBI36Build 36hg18NCBI36
Build 34122,191,504 - 22,214,916NCBI
Celera120,766,732 - 20,792,452 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,687,456 - 20,707,677 (-)NCBIHuRef
CHM1_1122,556,295 - 22,576,527 (-)NCBICHM1_1
T2T-CHM13v2.0121,941,071 - 21,966,860 (-)NCBIT2T-CHM13v2.0
Wnt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,004,946 - 137,026,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,004,800 - 137,027,037 (+)EnsemblGRCm39 Ensembl
GRCm384137,277,635 - 137,299,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,277,489 - 137,299,726 (+)EnsemblGRCm38mm10GRCm38
MGSCv374136,833,550 - 136,852,694 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,549,711 - 136,568,855 (+)NCBIMGSCv36mm8
Celera4135,495,983 - 135,515,320 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.8NCBI
Wnt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,797,245 - 154,818,565 (+)NCBIGRCr8
mRatBN7.25149,513,573 - 149,535,415 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,514,018 - 149,532,859 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,211,413 - 152,230,231 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,985,716 - 154,004,530 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,967,711 - 153,986,525 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,649,238 - 155,668,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,649,217 - 155,672,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,405,855 - 159,424,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,064,371 - 156,083,198 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,074,409 - 156,093,237 (+)NCBI
Celera5147,911,190 - 147,930,012 (+)NCBICelera
Cytogenetic Map5q36NCBI
WNT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21204,797,117 - 204,824,726 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,909,033 - 203,935,541 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,310,228 - 21,335,985 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,252,344 - 22,264,858 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,255,056 - 22,268,801 (-)Ensemblpanpan1.1panPan2
WNT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,112,045 - 77,129,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,101,300 - 77,127,111 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,659,490 - 77,687,070 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBIUU_Cfam_GSD_1.0
Wnt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,798,680 - 41,823,413 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,623,463 - 7,635,664 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,623,462 - 7,635,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1680,110,238 - 80,138,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,137,827 - 74,165,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,517,391 - 110,543,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,517,564 - 110,541,203 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,754,333 - 5,781,060 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,921,811 - 6,933,392 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247646,913,027 - 6,934,650 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000015605   ⟹   ENSCLAP00000015443
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554522,319,446 - 2,344,989 (-)Ensembl
RefSeq Acc Id: XM_005394734   ⟹   XP_005394791
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554522,319,446 - 2,344,740 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005394791 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000015443
  ENSCLAP00000015443.1
RefSeq Acc Id: XP_005394791   ⟸   XM_005394734
- UniProtKB: A0A8C2VGY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000015443   ⟸   ENSCLAT00000015605


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010626 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015605 ENTREZGENE
  ENSCLAT00000015605.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt4 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene Wnt4 ENTREZGENE
PANTHER PROTEIN WNT-4 UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT4PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A8C2VGY1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Wnt4  Wnt family member 4    wingless-type MMTV integration site family, member 4  Symbol and/or name change 5135510 APPROVED